药艾灸与清艾灸对脾虚痰湿型高脂血症患者脂质代谢的影响

发布时间：2018-08-28 09:48

【摘要】：目的：1.观察不同灸材艾条温和灸对脾虚痰湿型高脂血症患者TC、TG、HDL-C、 LDL-C、apoA、apoB和Lp(a)系列生化指标的影响；2.观察药艾灸与清艾灸对脾虚痰湿型高脂血症疗效的差异性。方法：90例符合纳入标准的脾虚痰湿型高脂血症患者随机分为药艾组、清艾组和对照组(血脂康组)三组,每组30例,施灸两组采用相同穴位处方：中脘、梁门(双)、气海、上巨虚(双)、丰隆(双)、公孙(双)。药艾条与清艾条应用艾条机自制,药艾条在艾绒中均匀混入复方中药粉,清艾条只用单纯艾绒,制成直径18mm、长度20cm规格的艾条。药艾组与清艾组应用灸架施灸,每穴温和灸40min,隔日施灸,每周灸疗三次,共施灸24次,疗程2个月。对照组口服血脂康胶囊,0.6g/次,2次/日,早晚饭后口服,疗程两个月。在治疗前和治疗后分别抽血检验血脂生化水平。结果：(1)治疗前,三组患者的TC、TG、HDL-C、LDL-C、apoA、apoB、年龄、性别和病程经统计学处理,无显著差异(P0.05),组间具有可比性。疗程结束后,对照组患者28例,脱落2例,显效21例,有效6例,无效1例,治疗总有效率为96.42%；药艾组患者29例,脱落1例,显效19例,有效8例,无效2例,治疗总有效率为93.10%；清艾组患者26例,脱落4例,显效15例,有效8例,无效3例,治疗总有效率为88.46%。组间比较三组治疗的有效率,无显著差异(P0.05)。(2)血清TC、TG、LDL-C、apoB含量指标,与治疗前相比,三组在治疗后均有降低,差异均有统计学意义(P0.05)；治疗后药艾组、清艾组与对照组比较,药艾组与清艾组比较,均无显著差异(P0.05)。(3)血清HDL-C、apoA含量指标,与治疗前相比,三组在治疗后均有升高,差异均有统计学意义(P0.05)；治疗后药艾组、清艾组与对照组比较,均无显著差异(P0.05)；药艾组与清艾组比较,有显著差异(P0.05),X药艾组HDL-cX清艾组HDL-c、X药艾组apoAX清艾组apoA。(4)血清Lp(a)含量指标,三组治疗前血清Lp(a)含量值经统计学处理,组间有显著差异,不具有可比性。治疗后,对照组、药艾组血清Lp(a)含量均有降低,与治疗前比较,差异具有统计学意义(P0.05)；清艾组与治疗前比较,无显著差异(P0.05)。结论：(1)药艾条与清艾条均可降低脾虚痰湿型高脂血症患者血清TC、TG、LDL-C和apoB水平,升高HDL-C和apoA水平,对血脂代谢具有良性调节作用,治疗有效。(2)药艾灸对升高脾虚痰湿型高脂血症患者血清HDL-C、apoA的作用优于清艾灸,且可适降低该证型高脂血症患者血清Lp(a)含量。
[Abstract]:Purpose 1. To observe the effect of mild moxibustion with different moxibustion materials on TC,TG,HDL-C, LDL-C,apoA,apoB and Lp (a) in hyperlipidemia patients with spleen deficiency and phlegm dampness. To observe the difference of curative effect between herbal moxibustion and clear moxibustion on hyperlipidemia with spleen deficiency and phlegm dampness. Methods 90 cases of hyperlipidemia with spleen deficiency and phlegm dampness type were randomly divided into three groups: Qingai group and control group (Xuezhikang group). 30 cases in each group were treated with the same acupoint prescription: Zhongwan, Liangmen (double) and Qihai, respectively. On Juxu (Shuang), Feng long (Shuang), Gongsun (Shuang). The medicine and the clear moxa are made by the moxa machine. The compound Chinese medicine powder is mixed evenly in the Ailong. The pure Artemisia lanceolata is used to make 18 mm diameter and length 20cm specification of the moxa. The two groups were treated with moxibustion by moxibustion frame for 40 mins and moxibustion every other day three times a week for a period of 2 months. In the control group, 0.6 g of Xuezhikang capsule was taken orally twice a day, and the course of treatment was two months after morning and evening meal. Blood samples were taken before and after treatment to examine the biochemical level of blood lipids. Results: (1) before treatment, there was no significant difference in TC,TG,HDL-C,LDL-C,apoA,apoB, age, sex and course of disease among the three groups (P0.05). At the end of the course of treatment, 28 patients in the control group were treated with abscission, 2 with abscission, 21 with remarkable effect, 6 with efficacy and 1 with no effect. The total effective rate was 96.42 in the control group, 29 patients in the control group, 1 case in the control group, 19 cases in the marked effect, 8 cases in the effective rate and 2 cases in the ineffective group. The total effective rate was 93.100.The total effective rate was 88.46 in the Qingai group (n = 26), there were 4 cases of shedding, 15 cases of remarkable effect, 8 cases of effective and 3 cases of ineffectiveness. There was no significant difference (P0.05). (2) in serum TC,TG,LDL-C,apoB content between the three groups. Compared with before treatment, the three groups were lower after treatment, the differences were statistically significant (P0.05); after treatment, the treatment group, Qingai group and control group were compared. Compared with Qingai group, there was no significant difference (P0.05). (3) in serum HDL-C,apoA content, compared with before treatment, the three groups were increased after treatment, the difference was statistically significant (P0.05); after treatment, the treatment group, Qing Ai group and control group were compared. There was no significant difference (P0.05), there was significant difference between the two groups (P0.05). (P0.05) the content of apoA. (4) in the apoA. (4) of the apoAX group was significantly higher than that of the control group (P0.05). The serum Lp (a) content of the three groups was significantly different before treatment, and there was significant difference between the three groups. There is no comparability. After treatment, the control group, the drug group, serum Lp (a) levels were decreased, compared with before treatment, the difference was statistically significant (P0.05); Qing Ai group and before treatment, there was no significant difference (P0.05). Conclusion: (1) the levels of serum TC,TG,LDL-C and apoB in patients with hyperlipidemia due to spleen deficiency and phlegm dampness can be decreased, and the levels of HDL-C and apoA are increased, which can regulate the metabolism of blood lipids. (2) the effect of drug moxibustion on raising serum HDL-C,apoA in patients with hyperlipidemia of spleen deficiency and phlegm dampness was better than that of clear moxibustion, and it could reduce serum Lp (a) content of patients with hyperlipidemia.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.1

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