自拟痛风方治疗痛风性关节炎临床研究

发布时间：2018-08-28 17:15

【摘要】：目的:采用随机对照临床试验方法,给予自拟痛风方治疗湿热蕴结型急性痛风性关节炎,观察患者治疗前、后各指标,并对实验结果进行分析。方法:本次实验患者采集于辽宁中医药大学附属二院骨科门诊及病房,共50例,依据急性痛风性关节炎诊断标准确诊,按照随机对照原则,将病人分为治疗组和对照组,每组25例,两组均饮食摄入干预,治疗组即结合组,给予自拟痛风方配合非布司他片治疗,对照组即西药组,给予口服非布司他片治疗,治疗一个疗程后,将VAS评分、症状体征和血尿酸浓度作为主要观察指标,并在疗程结束后随访2周,然后将观察结果进行统计学处理,评价该方治疗湿热蕴结型痛风性关节炎的疗效。结果:1.治疗后,两组VAS评分、关节肿胀、活动度评分和血尿酸浓度均下降。2.治疗后两组止痛效果比较,结合组止痛效果优于西药组。3.治疗后VAS评分、关节肿胀、活动度评分比较,结合组优于西药组。4.治疗后两组降血尿酸浓度比较,降血尿酸方面两组功能相近。5.随访于治疗一个疗程后2周,结合组优于西药组。结论:本次实验根据临床症状分析,结果显示自拟痛风方对治疗湿热蕴结型急性痛风性关节炎有一定的疗效,该方能够有效缓解急性期的症状、减轻疼痛,降低血尿酸数值,并可减少缓解期的复发,实验表明其副作用亦较小,为治疗痛风性关节炎提供了新方法。
[Abstract]:Objective: to treat acute gouty arthritis of dampness and heat accumulation type by random controlled clinical trial, observe the indexes before and after treatment, and analyze the experimental results. Methods: 50 patients were collected from orthopedic outpatient department and ward of the second affiliated Hospital of Liaoning University of traditional Chinese Medicine. According to the diagnostic criteria of acute gouty arthritis, the patients were divided into treatment group and control group according to the principle of random control. There were 25 cases in each group, both groups were treated with dietary intervention. The treatment group, that is, the combination group, was treated with self-made gout prescription combined with non-Budesta tablet, while the control group, the western medicine group, was treated with oral Festa tablet. After one course of treatment, the VAS score was evaluated. The symptoms and signs and serum uric acid concentration were taken as the main observation indexes and followed up for 2 weeks after the end of the course of treatment. Then the observation results were statistically processed to evaluate the efficacy of the prescription in treating dampness and heat accumulation type gouty arthritis. The result is 1: 1. After treatment, the VAS score, joint swelling, activity score and uric acid concentration decreased by 0. 2. 2 in both groups. After treatment, the analgesic effect of the combined group was better than that of the western medicine group. 3. After treatment, VAS score, joint swelling, activity score comparison, combined group is better than western medicine group. 4. After treatment, the blood uric acid concentration in the two groups was similar to that in the two groups, and the function of the two groups was similar to that of the control group. Two weeks after a course of treatment, the combination group was superior to the western medicine group. Conclusion: according to the analysis of clinical symptoms, the results show that the self-made gout prescription has certain curative effect on acute gouty arthritis of damp-heat accumulation type, and it can effectively relieve the symptoms of acute stage, relieve pain and reduce the value of blood uric acid. The results showed that the side effects were small, which provided a new method for the treatment of gouty arthritis.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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