电针对椎间盘脱出模型犬体感诱发电位的影响

发布时间：2018-09-06 12:14

【摘要】：目的研究电针对椎间盘脱出模型犬脊髓损伤的修复作用及其对体感诱发电位(somatosensory evoked potential,SEP)的影响。方法比格犬随机分为三组,模型组和电针组采用球囊压迫法制作椎间盘脱出模型,电针组术后每天电针治疗;对照组进行假手术处理。术前(0 d)和术后1、4、7、14 d每只犬均使用德克萨斯犬脊髓损伤Texas Spinal Cord Injury Scale for Dogs(TSCIS)评分法评分,使用肌电诱发电位仪测量SEP并分析其潜伏期和波幅。结果术后1 d模型组和电针组与对照组TSCIS评分相比均显著降低(P0.01),术后14 d,电针组与模型组相比差异有显著性(P0.01);术后4 d模型组和电针组的SEP潜伏期相比显著降低(P0.05),术后14 d,电针组与模型组的潜伏期相比差异有显著性(P0.05);术后1 d模型组和电针组的SEP波幅与对照组相比显著降低(P0.05),术后14 d,电针组与模型组的波幅相比差异有显著性(P0.05)。结论电针能够有效促进椎间盘脱出模型犬的脊髓损伤修复,提高TSCIS评分,恢复SEP波形,缩短其潜伏期,提升其波幅;SEP能够在一定程度上反应脊髓损伤程度,评价电针治疗效果。
[Abstract]:Objective to study the effect of electroacupuncture on repairing spinal cord injury and somatosensory evoked potential (somatosensory evoked potential,SEP) in dogs with prolapse of intervertebral disc. Methods Beagle dogs were randomly divided into three groups. The model group and the electroacupuncture group were used to make the model of prolapse of intervertebral disc by balloon compression. The electroacupuncture group was treated with electroacupuncture every day after operation, and the control group was treated with sham operation. The Texas Spinal Cord Injury Scale for Dogs (TSCIS) score of spinal cord injury in Texas canine was evaluated by Texas Spinal Cord Injury Scale for Dogs (TSCIS) score before operation (0 d) and 1 day 4 and 7 days after operation. SEP was measured by EMG potentiometer and its latency and amplitude were analyzed. Results the TSCIS scores in the model group and electroacupuncture group were significantly lower than those in the control group on the 1st day after operation (P0.01), and on the 14th day after operation, there was a significant difference between the electroacupuncture group and the model group (P0.01), and the latency of SEP in the model group and electroacupuncture group on the 4th day after operation was significantly lower than that in the control group (P0.01). (P0.05), 14 days after operation, the latency of electroacupuncture group and model group was significantly different (P0.05), the amplitude of SEP in model group and electroacupuncture group was significantly lower than that in control group on the 1st day after operation (P0.05), the amplitude of SEP in electroacupuncture group and model group was significantly higher than that in model group at 14 days after operation (P0.05). Conclusion electroacupuncture can effectively promote the repair of spinal cord injury in model dogs with intervertebral disc prolapse, improve the score of TSCIS, restore the waveform of SEP, shorten the latent period, increase the amplitude of SEP and reflect the degree of spinal cord injury to a certain extent, and evaluate the effect of electroacupuncture on the treatment of spinal cord injury.
【作者单位】：北京农学院动物科学技术学院;北京农学院兽医学(中医药)北京市重点实验室;
【基金】：国家自然科学基金项目(No.31372473) 北京农学院学位与研究生教育改革与发展项目(No.5056516004/024)
【分类号】：R245

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