十全大补汤配合艾灸疗法治疗NSCLC化疗后骨髓抑制（脾肾亏虚型）的临床研究

发布时间：2018-09-08 11:35

【摘要】：目的:本课题应用十全大补汤配合艾灸(膈俞穴、三阴交穴)疗法对NSCLC化疗后骨髓抑制(脾肾亏虚型)进行临床观察,以明确其疗效,治疗患者化疗后引起的骨髓抑制(脾肾亏虚型),延长患者生存期及改善其生活质量。方法:本课题将选取2015年3月——2015年12月长春中医药大学附属医院肿瘤血液科住院NSCLC化疗后I度骨髓抑制患者60例,随机分成两组,治疗组及对照组均为30例,采用平行对照的试验方法。治疗组用十全大补汤合并艾灸(膈俞穴、三阴交穴)疗法,对照组单纯使用十全大补汤治疗。治疗组:用十全大补汤水煎剂,每日一剂,早晚服用。艾灸疗法采用艾柱灸膈俞、三阴交两穴,每次每穴3壮,每天一次。上法配合使用15天,并分别于治疗前1天,治疗第7天,治疗第15天测定血常规以监测骨髓抑制程度。对照组:用十全大补汤水煎剂,每日一剂,早晚服用。疗程15天,并分别于治疗前1天,治疗第7天,治疗第15天测定血常规以监测骨髓抑制程度。在治疗前后,同时对中医临床症状、KPS评分状况进行比较。经相关统计学软件(spss.16.0)分析,对其疗效做出客观的评价。结果:本研究实际入组病例为60例。血象变化:治疗组外周血象中白细胞及中性粒细胞计数指标均明显优于对照组。中医症状改善情况:治疗组总有效率为86.67%;对照组总有效率为66.67%,治疗组在中医症状改善上有明显提高。生活质量改善情况:根据治疗后KPS评分结果,治疗组在改善人体功能状态方面疗效更好。结论:1、通过应用十全大补汤配合艾灸(膈俞穴、三阴交穴)疗法的治疗,可以明显改善NSCLC化疗后I度骨髓抑制患者的血象,并改善临床症状。2、药、灸合用的疗效优势不仅表现为化疗后骨髓抑制的改善,还表现为患者生活质量的提高及生存期的延长等。此外,此疗法疗效显著,具有深远的研究价值及开发前景。
[Abstract]:Objective: to observe the effect of Shiquan Dabu decoction combined with moxibustion (Geshu point, Sanyinjiao point) on bone marrow depression (deficiency of spleen and kidney) after NSCLC chemotherapy. The bone marrow depression (deficiency of spleen and kidney) caused by chemotherapy can prolong the survival time and improve the quality of life of the patients. Methods: from March 2015 to December 2015, 60 patients with degree I bone marrow suppression after NSCLC chemotherapy were randomly divided into two groups: 30 patients in the treatment group and 30 in the control group, in the department of tumor hematology, affiliated Hospital of Changchun University of traditional Chinese Medicine, from March 2015 to December 2015. A parallel controlled test was used. The treatment group was treated with Shiquan Da Bu decoction combined with moxibustion (Geshu point, Sanyinjiao point), while the control group was treated with Shiquan Da Bu decoction. The treatment group: take the decoction, one dose daily, morning and evening. Moxibustion therapy is used to moxibustion Geshu, Sanyinjiao two points, each point 3 strong, once a day. Combined therapy was used for 15 days, and blood routine was measured on day 15 before treatment and on day 7 to monitor the degree of bone marrow depression. The control group: take the decoction once a day and take it in the morning and evening. The course of treatment was 15 days, and the blood routine was measured on day 15, 1 day before treatment, 7 days before treatment and 15 days after treatment to monitor the degree of bone marrow suppression. At the same time, the KPS scores of TCM clinical symptoms were compared before and after treatment. The curative effect was evaluated objectively by correlation statistical software (spss.16.0). Results: there were 60 cases in this study. The changes of hematology: the leukocytes and neutrophils in peripheral blood of the treatment group were better than that of the control group. The improvement of TCM symptoms: the total effective rate of the treatment group was 86.67 and the total effective rate of the control group was 66.67. The improvement of the TCM symptoms in the treatment group was obviously improved. The improvement of quality of life: according to the KPS score after treatment, the treatment group has better effect in improving the function of human body. Conclusion: by applying Shiquan Da Bu Tang and moxibustion therapy (Geshu point, Sanyinjiao point), the hematology of patients with degree I bone marrow depression after NSCLC chemotherapy can be obviously improved, and the clinical symptoms. The advantages of combined moxibustion were not only the improvement of bone marrow suppression after chemotherapy, but also the improvement of patients' quality of life and the prolongation of survival time. In addition, the therapeutic effect is significant, and has a profound research value and development prospects.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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