参红通络方对不稳定性心绞痛生化指标影响的临床研究

发布时间：2018-09-08 13:35

【摘要】：目的:观察西医标准化治疗加参红通络方与单纯西医标准化治疗,在改善不稳定性心绞痛患者基质金属蛋白酶9(MMP-9)、妊娠相关蛋白A(PAPP-A)、CRP、HCY、BNP指标方面的差异。方法:将已确诊的不稳定性心绞痛患者160例,随机分为对照组80例,治疗组80例。对照组给予西药常规治疗加安慰剂,治疗组给予西药常规治疗加参红通络方。用药2周,以治疗后1周、2周为疗效评价点,观察不稳定性心绞痛患者MMP-9、PAPP-A、CRP、HCY、BNP指标方面的差异。结果:血清MMP-9、PAPP-A、CRP、HCY、BNP水平在治疗组与对照组用药前、治疗1周和治疗2周后,同组组内前后比较差异有统计学意义(P0.05)。治疗前血清MMP-9、PAPP-A、CRP、HCY、BNP水平在治疗组和对照组组间比较,两组患者一般情况差异无统计学意义(P0.05)。治疗1周血清MMP-9、PAPP-A、CRP、HCY、BNP水平在治疗组、对照组组间对比,两组组间比较差异有统计学意义(P0.05);治疗2周血清MMP-9、PAPP-A、CRP、HCY、BNP水平在治疗组、对照组组间对比,两组组间比较差异有统计学意义(P0.05);两组于治疗1周和治疗2周时,治疗组均比对照组在降低血清MMP-9、PAPP-A、CRP、HCY、BNP水平方面更显著。结论:西医标准化治疗加参红通络方比单纯西医标准化治疗在治疗不稳定性心绞痛方面,明显改善血清MMP-9、PAPP-A、CRP、HCY、BNP水平,是治疗不稳定性心绞痛的有效治疗方法。
[Abstract]:Objective: to observe the difference of the indexes of matrix metalloproteinase 9 (MMP-9) and pregnancy associated protein A (PAPP-A) in patients with unstable angina pectoris treated with Shenghong Tongluo recipe and simple western standardized treatment in order to observe the difference of the indexes of matrix metalloproteinase 9 (MMP-9) and pregnancy associated protein A (PAPP-A) in patients with unstable angina pectoris. Methods: 160 patients with unstable angina pectoris were randomly divided into control group (n = 80) and treatment group (n = 80). The control group was treated with routine western medicine plus placebo, and the treatment group with Shenhong Tongluo prescription. The difference of MMP-9,PAPP-A,CRP,HCY,BNP indexes in patients with unstable angina pectoris was observed 2 weeks after treatment and 2 weeks after treatment. Results: the level of serum MMP-9,PAPP-A,CRP,HCY,BNP was significantly different between the treatment group and the control group before and after 1 week and 2 weeks treatment (P0.05). Before treatment, the level of serum MMP-9,PAPP-A,CRP,HCY,BNP between the treatment group and the control group, there was no significant difference between the two groups (P0.05). The serum MMP-9,PAPP-A,CRP,HCY,BNP level in the treatment group and the control group was significantly higher than that in the control group (P0.05), the serum MMP-9,PAPP-A,CRP,HCY,BNP level in the treatment group and the control group was higher than that in the control group at 2 weeks after treatment (P0.05). The difference between the two groups was statistically significant (P0.05). After 1 week of treatment and 2 weeks of treatment, the level of serum MMP-9,PAPP-A,CRP,HCY,BNP in the treatment group was significantly lower than that in the control group. Conclusion: the standard treatment of western medicine plus Shenghong Tongluo recipe is more effective in the treatment of unstable angina pectoris than in the treatment of unstable angina pectoris. It is an effective method to treat unstable angina pectoris.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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