补肺益寿合剂对肺肾阴虚证支气管哮喘缓解期肺功能的影响
发布时间：2018-09-09 19:29
【摘要】：目的:观察补肺益寿合剂对肺肾阴虚证支气管哮喘缓解期肺功能的影响,突出中医药治疗支气管哮喘的优势,让更多患者受益。方法:选取符合纳入标准的支气管哮喘患者40例,口服补肺益寿合剂10瓶/年,服药时间分三个阶段:第一阶段:每年冬至开始服药,每次50ml,2次/日,连续口服7.5天(共3瓶)后停药;第二阶段:三九第一天开始服药,每次50ml,2次/日,连续口服10天(共4瓶)后停药;第三阶段:五九第一天开始口服补肺益寿合剂,每次50ml,2次/日,连续口服7.5天(共3瓶)后停药。每1年为1个疗程,观察期为3年,每年对40位患者的FEV1/FVC、FEV1、PEF%的检测值分别记录,并对治疗前后数据进行分析。所有数据采用统计软件SPSS20.0进行统计学处理。结果:(1)中医症状积分比较:补肺益寿合剂能明显缓解肺肾阴虚证支气管哮喘缓解期患者的喘息、咳嗽咯痰、平素短息气促、胸膈满闷、口干烦热、手足心热、盗汗、腰膝酸软症状(P0.05)。(2)治疗前后FEV1/FVC、FEV1、PEF%数值变化比较:从治疗前FEV1/FVC、FEV1、PEF%和疗后FEV1/FVC、FEV1、PEF%的P-P图可以看出,这两组数据满足正态分布,且从成对样本相关系数上看出该统计适合进行配对样本t检验。结果显示每组比较的成对样本统计量治疗前-治疗后的差值均为负值,据此可推断出补肺益寿合剂可以改善支气管哮喘患者的FEV1/FVC、FEV1、PEF%的值,即治疗后FEV1/FVC、FEV1、PEF%数值均呈上升趋势(P0.05)。(3)入组患者治疗前后均未见明显毒副作用及不良反应。结论:补肺益寿合剂治疗肺肾阴虚证支气管哮喘缓解期有较好的临床疗效,并能明显改善患者的肺功能,在治疗过程中未发现明显不良反应,可在临床上推广应用。
[Abstract]:Aim: to observe the effect of Bufei Yishou mixture on lung function in remission stage of bronchial asthma with deficiency of lung and kidney yin, highlight the advantages of traditional Chinese medicine in treating bronchial asthma, and benefit more patients. Methods: 40 patients with bronchial asthma who met the inclusion criteria were selected and 10 bottles per year were taken orally with Bufei Yishou mixture. The time of taking the drugs was divided into three stages: the first stage: the Winter Solstice began taking drugs twice a day, 50 ml / day each year. After taking 7.5 consecutive days of oral administration (3 bottles in total), the second stage: start taking medicine on the first day of the ninth, 50 ml / day twice a day, take orally continuously for 10 days (4 bottles), then stop the drug; stage 3: the first day of 59th begins to take Bu Fei Yishou mixture, After 50 ml / d, 7.5 days (3 bottles), the drug was stopped. Each year was a course of treatment and the observation period was 3 years. The FEV1/FVC,FEV1,PEF% values of 40 patients were recorded each year and the data before and after treatment were analyzed. All the data were processed by statistical software SPSS20.0. Results: (1) comparison of TCM symptom score: Bufei Yishou mixture could obviously relieve wheezing, coughing phlegm, short breath shortness of breath, fullness of chest and diaphragm, dryness of mouth, hot heart of hand and foot, night sweat in patients with asthma of lung and kidney yin deficiency syndrome. Comparison of FEV1/FVC,FEV1,PEF% values before and after treatment (P0.05). (2): from the P-P diagram of FEV1/FVC,FEV1,PEF% and FEV1/FVC,FEV1,PEF% before and after treatment, we can see that the two groups of data satisfy normal distribution, and from the correlation coefficient of paired samples, it can be seen that this statistic is suitable for paired samples t test. The results showed that the difference between pre-treatment and post-treatment of paired sample statistics in each group was negative. It was inferred that Bufei Yishou mixture could improve the value of FEV1/FVC,FEV1,PEF% in patients with bronchial asthma. That is to say, the value of FEV1/FVC,FEV1,PEF% increased after treatment (P0.05). (3). There were no obvious side effects and adverse reactions before and after treatment. Conclusion: Bufei Yishou mixture has good clinical effect in treating bronchial asthma with deficiency of lung and kidney yin, and can obviously improve the pulmonary function of the patients. No obvious adverse reactions were found in the course of treatment, so it can be popularized and applied in clinic.
【学位授予单位】：甘肃中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2233354
[Abstract]:Aim: to observe the effect of Bufei Yishou mixture on lung function in remission stage of bronchial asthma with deficiency of lung and kidney yin, highlight the advantages of traditional Chinese medicine in treating bronchial asthma, and benefit more patients. Methods: 40 patients with bronchial asthma who met the inclusion criteria were selected and 10 bottles per year were taken orally with Bufei Yishou mixture. The time of taking the drugs was divided into three stages: the first stage: the Winter Solstice began taking drugs twice a day, 50 ml / day each year. After taking 7.5 consecutive days of oral administration (3 bottles in total), the second stage: start taking medicine on the first day of the ninth, 50 ml / day twice a day, take orally continuously for 10 days (4 bottles), then stop the drug; stage 3: the first day of 59th begins to take Bu Fei Yishou mixture, After 50 ml / d, 7.5 days (3 bottles), the drug was stopped. Each year was a course of treatment and the observation period was 3 years. The FEV1/FVC,FEV1,PEF% values of 40 patients were recorded each year and the data before and after treatment were analyzed. All the data were processed by statistical software SPSS20.0. Results: (1) comparison of TCM symptom score: Bufei Yishou mixture could obviously relieve wheezing, coughing phlegm, short breath shortness of breath, fullness of chest and diaphragm, dryness of mouth, hot heart of hand and foot, night sweat in patients with asthma of lung and kidney yin deficiency syndrome. Comparison of FEV1/FVC,FEV1,PEF% values before and after treatment (P0.05). (2): from the P-P diagram of FEV1/FVC,FEV1,PEF% and FEV1/FVC,FEV1,PEF% before and after treatment, we can see that the two groups of data satisfy normal distribution, and from the correlation coefficient of paired samples, it can be seen that this statistic is suitable for paired samples t test. The results showed that the difference between pre-treatment and post-treatment of paired sample statistics in each group was negative. It was inferred that Bufei Yishou mixture could improve the value of FEV1/FVC,FEV1,PEF% in patients with bronchial asthma. That is to say, the value of FEV1/FVC,FEV1,PEF% increased after treatment (P0.05). (3). There were no obvious side effects and adverse reactions before and after treatment. Conclusion: Bufei Yishou mixture has good clinical effect in treating bronchial asthma with deficiency of lung and kidney yin, and can obviously improve the pulmonary function of the patients. No obvious adverse reactions were found in the course of treatment, so it can be popularized and applied in clinic.
【学位授予单位】：甘肃中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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