龟鹿二仙胶汤治疗肝肾亏虚型膝关节骨性关节炎的临床疗效研究

发布时间：2018-09-10 11:00

【摘要】：目的:通过观察龟鹿二仙胶汤加减与口服盐酸氨基葡萄糖胶囊治疗膝关节骨性关节炎(KOA)的临床疗效对比,探讨龟鹿二仙胶在临床上治疗膝骨性关节炎的疗效。方法:采取回顾性分析,根据纳入标准筛取的病例从大连市第二人民医院骨科就诊的膝关节骨性关节炎患者64例,按照随机分配的原则进行分组,治疗组和对照组各有32例。龟鹿二仙胶汤作为治疗组口服,氨基葡萄糖胶囊作为对照组,二者均治疗观察疗效8周。最后根据统计出来的评分疗效对二组进行评估,比较二者在疗效上的恢复差异情况。结果:首先在ISOA评分上,治疗组的无效数为2例,总有效数30例;氨基葡萄糖对照组的无效数为4例,总有效数是28例,治疗组有效率为92.86%,对照组总有效率为85.36%,经过秩和检验,P0.05,说明两组在改善膝关节功能上没有显著差异;在VAS评分疗效上,治疗组无效1例,有效31例,有效率为93.75%;对照组无效4例,有效率28例,有效率为87.24%,P0.05说明两组在膝关节疼痛改善上没有明显差异。结论:龟鹿二仙胶汤治疗膝关节骨性关节炎与盐酸氨基葡萄糖胶囊治疗膝关节骨性关节炎在起效时间,对疼痛的缓解的差异并不明显,疗效相当。相比患者容易接受,绿色安全,值得临床推广。
[Abstract]:Objective: to observe the clinical efficacy of Guilu Erxian decoction and oral glucosamine hydrochloride capsule in the treatment of knee osteoarthritis (KOA) and to explore the clinical efficacy of Guilu Erxian capsule in the treatment of knee osteoarthritis. Methods: according to the standard sieve, 64 cases of knee osteoarthritis from the orthopedic department of the second people's Hospital of Dalian were divided into two groups according to the principle of random distribution. There were 32 cases in treatment group and 32 cases in control group. Guilu Erxianjiao decoction was taken orally in the treatment group and glucosamine capsule was used as the control group. Both of them were treated for 8 weeks. Finally, the two groups were evaluated according to the statistical scores, and the difference of curative effect between the two groups was compared. Results: in the ISOA score, the invalid number was 2 cases, the total effective number was 30 cases in the treatment group, 4 cases in the glucosamine control group, and 28 cases in the glucosamine control group. The effective rate of the treatment group was 92.86 and the total effective rate of the control group was 85.36.The rank sum test showed that there was no significant difference between the two groups in improving the function of the knee joint, and in the effect of VAS score, the treatment group had no effect in 1 case and the effective rate in 31 cases. The effective rate was 93.75 and the control group was ineffective in 4 cases and the effective rate in 28 cases. The effective rate was 87.24 points out that there was no significant difference in the improvement of knee joint pain between the two groups. Conclusion: Guilu Erxianjiao decoction in the treatment of knee osteoarthritis and glucosamine hydrochloride capsule in the treatment of knee osteoarthritis in the effective time, the pain relief difference is not obvious, the curative effect is the same. Compared with the patient is easy to accept, green safety, worthy of clinical promotion.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9

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