蒲地蓝消炎口服液治疗小儿化脓性扁桃体炎有效性及安全性的系统评价

发布时间：2018-09-11 15:15

【摘要】：该文通过系统检索相关电子数据库,收集相关文献,对蒲地蓝消炎口服液治疗小儿化脓性扁桃体炎的有效性及安全性进行系统评价。最终纳入18篇随机对照试验,涉及1 883例化脓性扁桃体炎患儿,蒲地蓝试验组957例,抗生素对照组926例。Meta结果显示:与单独应用抗生素相比,联合服用蒲地蓝可有效提高小儿化脓性扁桃体炎治疗的总有效率,缩短患儿的体温恢复正常时间,缩短扁桃体脓性分泌物消失时间,也能减少咽痛消失时间、扁桃体肿大或充血消退时间、食欲精神恢复时间。治疗期间蒲地蓝试验组均无严重不良反应。该研究表明:与单独使用抗生素相比,联合应用蒲地蓝能更有效安全地治疗小儿化脓性扁桃体炎,但由于文献研究质量偏低,上述结论有待高质量临床试验进一步验证。
[Abstract]:The efficacy and safety of Pudilan Xiaoyan Oral liquid in the treatment of infantile suppurative tonsillitis were systematically evaluated by searching relevant electronic database and collecting relevant literature. 18 randomized controlled trials involving 1,883 children with suppurative tonsillitis, 957 cases in the Prudilan trial group and 926 cases in the antibiotic control group were included. The combined use of bushy blue can effectively improve the total effective rate of the treatment of suppurative tonsillitis in children, shorten the time of recovery of body temperature, shorten the time of disappearance of purulent secretion of tonsil, and also reduce the time of disappearance of pharynx pain. Tonsillar swelling or hyperemia regression time, appetite recovery time. There were no serious adverse reactions in the test group during treatment. This study showed that compared with antibiotics alone, combined use of blue can be more effective and safe in the treatment of suppurative tonsillitis in children. However, due to the low quality of literature research, these conclusions need to be further verified in high quality clinical trials.
【作者单位】：天津中医药大学;天津中医药大学第二附属医院;天津中医药大学循证医学中心;
【基金】：教育部新世纪优秀人才项目(NCET-13-0936) 天津市青年拔尖人才项目
【分类号】：R276.1

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