补肾活血促卵方对肾虚血瘀型多囊卵巢综合征所致不孕症的临床疗效

发布时间：2018-09-14 12:04

【摘要】：目的观察补肾活血促卵方对血瘀型多囊卵巢综合征所致不孕症的临床疗效。方法随机选取肾虚血瘀型多囊卵巢综合征所致不孕症患者,其中40例作为试验组,40例作为对照组。从月经第5天,试验组患者开始服用补肾活血促卵方,每次服用200 m L,每日1剂,早晚2次服用,连服14 d;对照组患者开始服用克罗米芬,每次50~100 mg,每日1次,连服5 d,治疗3~6个月。用彩色多普勒超声诊断仪检测患者子宫内膜、卵泡的发育情况;用化学发光免疫法检测患者的胰岛素(INS)、促黄体激素(LH)、促卵泡激素(FSH)、垂体泌乳素(PRL)、睾酮(T)、雌二醇(E2)水平;用自拟定的疗效诊断标准计算患者的排卵率、妊娠率。比较2组治疗前后患者的排卵率、妊娠率、卵泡数量、血清性激素、子宫内膜厚度及卵巢体积变化等变化。结果对照组与试验组的妊娠率分别为30%,55%,组间比较差异均有统计学意义(P0.05);对照组与试验组的排卵率分别为73%,59.4%,组间比较差异均有统计学意义(P0.05)。与治疗前比较,对照组的FSH、E2差异有统计学意义(均P0.05);试验组的FSH、T、PRL、LH、INS及E2差异均有统计学意义(均P0.05)。治疗前,对照组与试验组患者的双侧卵巢直径2~9 mm的卵泡数量分别为(15.8±1.9),(16.6±2.1)个;2组的子宫内膜厚度分别为(6.9±1.48),(6.35±1.52)mm;2组的卵巢体积分别为(11.23±4.12),(10.51±4.51)m L。治疗后,对照组与试验组患者的卵泡数量分别为(12.9±2.2),(9.8±1.0)个;2组的子宫内膜厚度分别为(7.96±2.1),(9.82±1.02)mm;2组的卵巢体积分别为(9.75±3.8),(8.15±2.35)m L。与治疗前比较,试验组患者的卵泡数量、子宫内膜厚度、卵巢的体积,差异均有统计学意义(P0.05);而对照组患者的卵泡数量、子宫内膜厚度及卵巢的体积差异均无统计学意义(P0.05)。说明补肾活血促卵方对肾虚血瘀型多囊卵巢综合征有明显的改善作用。结论补肾活血促卵方能降低LH、提高FSH水平,增加卵泡数量,有利于成熟卵泡的发育,提高排卵率,同时可以补肾活血。
[Abstract]:Objective to observe the clinical effect of Bushen Huoxue Chuan Fang on infertility caused by polycystic ovary syndrome of blood stasis type. Methods 40 cases of infertility caused by polycystic ovary syndrome with kidney deficiency and blood stasis were randomly selected as the control group (40 cases). From the 5th day of menstruation, the patients in the test group began to take the prescription of tonifying kidney, activating blood circulation and promoting eggs, taking 200ml, once a day, twice a day in the morning and evening, and taking clomiphene for 14 days, while the patients in the control group took clomiphene once a day for 50 minutes per day. For 5 days, the patients were treated for 3 ~ 6 months. The development of endometrium and follicle was detected by color Doppler ultrasound, the levels of insulin (INS), luteinizing hormone (LH), follicle stimulating hormone (FSH), pituitary prolactin (PRL), testosterone (T), estradiol (E 2) were detected by chemiluminescence immunoassay. The ovulation rate and pregnancy rate were calculated by self-designed therapeutic criteria. The ovulation rate, pregnancy rate, follicle number, serum sex hormone, endometrial thickness and ovarian volume were compared before and after treatment. Results the pregnancy rate of the control group and the test group were 30 and 555.The difference between the two groups was statistically significant (P0.05), while the ovulation rate of the control group and the test group was 739.4g, the difference between the two groups was statistically significant (P0.05). Compared with before treatment, the difference of FSH,E2 in control group was statistically significant (P0.05), and the difference of FSH,T,PRL,LH,INS and E2 in test group was statistically significant (P0.05). Before treatment, the number of follicles with a bilateral ovarian diameter of 2 ~ 9 mm in the control group and the experimental group was (15.8 卤1.9), (, 16.6 卤2.1). The endometrial thickness of the two groups was (6.9 卤1.48), (, 6.35 卤1.52) mm;2, respectively, and the ovarian volume was (11.23 卤4.12), (, 10.51 卤4.51) m L.), respectively. After treatment, the number of follicles in the control group and the experimental group was (12.9 卤2.2), (9.8 卤1.0). The endometrial thickness of the two groups was (7.96 卤2.1), (, 9.82 卤1.02) mm;2, and the ovarian volume was (9.75 卤3.8), (, 8.15 卤2.35) m L.), respectively. Compared with before treatment, the number of follicles, the thickness of endometrium, the volume of ovary were significantly different in the experimental group (P0.05), while the number of follicles, the thickness of endometrium and the volume of ovary were not significantly different in the control group (P0.05). It indicated that the prescription of tonifying kidney and activating blood circulation and promoting egg had obvious effect on polycystic ovary syndrome of kidney deficiency and blood stasis. Conclusion Bushen Huoxue recipe can decrease LH, increase the number of follicles, improve the development of mature follicles, increase ovulation rate, and tonify the kidney and promote blood circulation.
【作者单位】：海南医学院中医学院中医妇儿教研室;海南医学院中医学院中西结合妇儿教研室;海南医学院附属医院中医科;海南省中医院妇产科;
【基金】：海南省卫生厅科研立项基金资助项目(琼卫2011-53)
【分类号】：R271.14

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