健脾疏肝活血化痰方治疗肝郁脾虚型非酒精性脂肪性肝炎的临床疗效观察

发布时间：2018-09-14 20:16

【摘要】：目的探讨健脾疏肝活血化痰方治疗肝郁脾虚型非酒精性脂肪性肝炎的临床疗效。方法选取2015年10月-2016年10月我院收治的140例非酒精性脂肪性肝炎且中医辨证分型为肝郁脾虚型患者,将其按照随机数字法随机分为观察组和对照组,2组均给予运动、饮食治疗,对照组在此基础上给予多烯磷脂酰胆碱胶囊,观察组在对照组基础上给予健脾疏肝活血化痰方加减治疗。结果治疗后2组症状积分及临床症状总积分均显著下降(P0.01),但观察组下降更为明显(P0.01)。治疗后观察组总体疗效总有效率为94.28%,显著高于对照组(77.14%,P0.01)。治疗后观察组中医证候总有效率为95.71%,显著高于对照组(77.14%,P0.01)。治疗后2组ALT、AST、GGT水平均显著下降(P0.01),但观察组下降更为明显(P0.01)。治疗后2组腹部B超情况均显著改善(P0.01),但观察组改善更为明显(P0.01)。治疗期间2组患者未诉其他不适及不良反应和毒副作用。结论健脾疏肝活血化痰方可显著改善肝郁脾虚型非酒精性脂肪性肝炎患者的临床症状和肝功能。
[Abstract]:Objective to investigate the clinical effect of Jianpi Shugan Huatan recipe in the treatment of non-alcoholic fatty hepatitis with liver stagnation and spleen deficiency. Methods 140 cases of non-alcoholic fatty hepatitis with syndrome differentiation of liver stagnation and spleen deficiency were selected from October 2015 to October 2016. They were randomly divided into observation group and control group according to random numbers. Both groups were given exercise and diet therapy. The control group was given Polyene phosphatidylcholine capsule on this basis, and the observation group was treated with Jianpi Shugan Huatan decoction on the basis of the observation group. Results after treatment, the symptom score and the total clinical symptom score of the two groups decreased significantly (P0.01), but the decrease of the observation group was more obvious (P0.01). The total effective rate of the observation group was 94.28, which was significantly higher than that of the control group (77.14 and P0.01). After treatment, the total effective rate of TCM syndrome in observation group was 95.71, significantly higher than that in control group (77.14 and P0.01). The level of ALT,AST,GGT decreased significantly in both groups after treatment (P0.01), but more significantly in the observation group (P0.01). After treatment, the abdominal B ultrasound was significantly improved in both groups (P0.01), but the improvement was more obvious in the observation group (P0.01). During the treatment, no other discomfort, adverse reactions and side effects were reported in the two groups. Conclusion Jianpi Shugan Huoxue Huatan decoction can significantly improve the clinical symptoms and liver function in patients with non-alcoholic fatty hepatitis with liver stagnation and spleen deficiency.
【作者单位】：遵义医学院附属医院;
【基金】：四川省卫生厅科研基金(120468)
【分类号】：R259

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