大柴胡汤加味对急危重症患者应激状态下肠道屏障功能的影响

发布时间：2018-09-16 20:21

【摘要】：目的观察大柴胡汤加味对急危重症患者应激状态下肠道屏障功能的影响。方法将102例急危重症患者随机分为对照组和观察组各51例,对照组给予常规肠胃复苏治疗,观察组在对照组治疗基础上给予大柴胡汤加味胃管灌注,早晚各1次,直至排气恢复。观察2组治疗前及治疗7 d后肠功能障碍评分及血二胺氧化酶(DAO)、肠脂肪酸结合蛋白(IFABP)、尿乳果糖/甘露醇(L/M)水平变化情况,统计2组腹腔器官感染及肠道细菌全身感染发生率。结果治疗7 d后,2组肠功能障碍评分≤1分比例均明显高于治疗前(P均0.05),而≥3分比例则明显低于治疗前(P均0.05),且观察组≤1分比例明显高于对照组(P0.05),≥3分比例明显低于对照组(P0.05);2组DAO均明显升高(P均0.05),IFABP、L/M均明显降低(P均0.05),且观察组各指标改善情况明显优于对照组(P均0.05)。观察组腹腔器官感染及肠道细菌全身感染发生率均明显低于对照组(P均0.05)。结论大柴胡汤加味治疗急危重症患者应激状态下肠道屏障功能可明显改善肠道功能障碍,减轻肠道炎性反应,并有效降低感染发生率,可在临床推广应用。
[Abstract]:Objective to observe the effect of Dachaihu decoction on intestinal barrier function in acute and critical patients. Methods 102 patients were randomly divided into control group (n = 51) and observation group (n = 51). The control group was treated with routine gastrointestinal resuscitation. The observation group was treated with Dachaihu decoction plus modified gastric tube on the basis of the treatment in the control group, one time in the morning and evening. Until the exhaust recovers. The scores of intestinal dysfunction and the levels of serum diamine oxidase (DAO),) intestinal fatty acid binding protein (IFABP), lactulose / mannitol (L / M), were observed before and 7 days after treatment in the two groups. The incidence of celiac organ infection and enterobacterial bacterial systemic infection were counted. Results after 7 days of treatment, the proportion of intestinal dysfunction score 鈮，

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