固元祛斑膏方治疗黄褐斑（肝肾不足型）的临床疗效观察

发布时间：2018-09-16 22:05

【摘要】：目的本研究进行了一项自身前后比较的临床试验研究,通过对比膏方治疗前后黄褐斑皮损面积积分、颜色积分、总积分以及总积分下降指数的变化来评价膏方治疗黄褐斑的疗效性及安全性,以期能够探索出有效调治黄褐斑的膏方治疗方法及膏方制剂。方法本研究选取黄褐斑患者为研究对象,进行自身前后对照研究。将符合纳入标准、签署知情同意书的45例患者做为实验组。受试者需要接受3个月的膏方治疗,并于入组当天、治疗第4周、第8周、第12周复诊时,记录皮损面积、皮损颜色、皮损严重程度评分等观察指标；同时进行CBS皮肤图像分析系统检测,记录靶皮损色素程度百分比;询问用药依从性,记录合并用药及不良反应及复发情况。借助统计学软件SPSS19.0对各组资料进行统计分析,作出疗效判定及结果分析。结果实验组痊愈1例,显效14例,有效20例,无效7例,总有效率为83.3%：实验组治疗前后总疗效比较,经t检验,P=0.0350.05,差异有统计学意义。说明实验组治疗12周后与治疗前有明显差异,说明该种治疗方法可明显改善黄褐斑综合积分皮损,对黄褐斑的治疗是有明显疗效的。结论本研究确证了膏方对黄褐斑患者的临床疗效,通过临床干预和疗效观察,本研究得出结论,膏方是治疗黄褐斑的安全有效方法,通过治疗能有效改善黄褐斑患者面部皮损大小、颜色程度、色素程度,因其临床疗效确切、安全、有效,故值得推广使用。
[Abstract]:Objective in this study, a clinical trial study was conducted to compare the area and color of chloasma skin before and after treatment with ointment. To evaluate the efficacy and safety of ointment in the treatment of chloasma with the change of total integral and decrease index of total integral, in order to explore the effective treatment method and preparation of cream for chloasma. Methods in this study, chloasma patients were selected for self-control study. A total of 45 patients who met the inclusion criteria and signed informed consent were selected as experimental group. The subjects were treated with ointment for 3 months. On the day of treatment, 4 weeks, 8 weeks and 12 weeks of treatment, the area of skin lesions, the color of skin lesions and the severity of skin lesions were recorded. At the same time, the CBS skin image analysis system was used to record the percentage of pigment degree in target skin lesions, to inquire about drug compliance, and to record the combined drug use, adverse reactions and recurrence. Statistical software SPSS19.0 was used to analyze the data of each group. Results in the experimental group, 1 case was cured, 14 cases were markedly effective, 20 cases were effective, 7 cases were ineffective. The total effective rate was 83.3%. The total curative effect of the experimental group was compared before and after treatment, and the difference was statistically significant. The results showed that there was significant difference between the experimental group and the control group after 12 weeks treatment, which indicated that this treatment method could obviously improve the integrated integral lesions of chloasma, and the treatment of chloasma had obvious curative effect. Conclusion this study confirmed the clinical effect of plaster on chloasma patients. Through clinical intervention and curative effect observation, the study concluded that plaster prescription is a safe and effective method for the treatment of chloasma. The treatment can effectively improve the size, color degree and pigment degree of facial skin lesions in patients with chloasma. It is worth popularizing because of its definite, safe and effective clinical effect.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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