益气百合汤治疗胃食管反流病的临床研究

发布时间：2018-10-09 16:45

【摘要】：目的:观察益气百合汤治疗胃食管反流病的临床疗效,并从理论上探讨益气百合汤治疗胃食管反流病的作用机制。方法:病例来源:98例胃食管反流病患者,均来自2015年1月-2016年9月于青岛大学附属医院中医科门诊就诊患者。随机分为治疗组和对照组:治疗组50例,对照组48例。治疗方案:治疗组给予益气百合汤治疗,对照组给予奥美拉唑肠溶片联合枸橼酸莫沙必利片进行治疗,4周为1个疗程,两组均连续服用2个疗程。治疗2个疗程后进行临床疗效观察,对血常规、尿常规、粪常规、肝肾功、心电图等其他可能出现的不良反应做出安全性评价,分析患者治疗前后的症状、体征、中医症候积分、胃镜下食管黏膜变化情况和长期疗效。结果:(1)临床综合疗效:治疗组的总有效率93.88%,脱落1例,治愈13例,显效22例,有效11例,无效3例;对照组的总有效率80.43%,脱落2例,治愈7例,显效16例,有效14例,无效9例,治疗组总有效率明显优于对照组(P0.05)。(2)中医症候比较:治疗后两组患者中医症候总积分较治疗前均有所下降,差异有统计学意义(P0.05)。治疗后烧心、反酸、胸骨后灼痛、嗳气或呃逆、咽部不适和纳呆等症状的改善治疗组明显优于对照组,差异有统计学意义(P0.05)。(3)胃镜下黏膜改善:胃镜下黏膜炎症的改善治疗组与对照组比较无统计学意义(P0.05)。(4)长期疗效:停服药物6个月后随访治愈患者,治疗组13例,复发2例;对照组7例,复发5例。差异有统计学意义(P0.05)。结论:益气百合汤治疗胃食管反流病疗效确切,能有效减轻患者临床症状,改善患者生活质量,同时不良反应低,使用安全,患者可以接受长期治疗。
[Abstract]:Objective: to observe the clinical effect of Yiqilihe decoction in treating gastroesophageal reflux disease, and to explore the mechanism of YQLi decoction in treating gastroesophageal reflux disease theoretically. Methods: 98 cases of gastroesophageal reflux disease from January 2015 to September 2016 in Qingdao University Hospital. They were randomly divided into treatment group (n = 50) and control group (n = 48). The treatment plan: the treatment group was treated with Yiqilui decoction, the control group was treated with omeprazole enteric-coated tablet combined with mosapride citrate tablet for 4 weeks as a course of treatment, and the two groups were taken continuously for 2 courses. After two courses of treatment, the clinical curative effect was observed, and the safety of blood routine, urine routine, fecal routine, liver and kidney function, electrocardiogram and other possible adverse reactions were evaluated, and the symptoms and signs of the patients before and after treatment were analyzed. TCM symptom score, gastroscope esophageal mucosal changes and long-term efficacy. Results: (1) Clinical comprehensive curative effect: the total effective rate was 93.88 in the treatment group, 1 case in the treatment group, 13 cases in cure, 22 cases in remarkable effect, 11 cases in effectiveness and 3 cases in ineffectiveness, while in the control group, the total effective rate was 80.43%, 2 cases fell out, 7 cases were cured, 16 cases were effective, and 14 cases were effective. The total effective rate in the treatment group was significantly better than that in the control group (P0.05). (2). After treatment, the total score of TCM symptoms in the two groups decreased compared with that before treatment, and the difference was statistically significant (P0.05). The improvement of symptoms such as heartburn, regurgitation, post-sternal pain, belching or hiccup, pharynx discomfort and anorexia were significantly better in the treatment group than in the control group. The difference was statistically significant (P0.05). (3): there was no significant difference in the improvement of mucosal inflammation between the treatment group and the control group (P0.05). (4). There were 7 cases in the control group and 5 cases in the recurrence group. The difference was statistically significant (P0.05). Conclusion: Yiqihe decoction is effective in the treatment of gastroesophageal reflux disease. It can effectively alleviate the clinical symptoms and improve the quality of life of the patients. At the same time, the adverse reaction is low, the use is safe, and the patients can be treated for a long time.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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