蜥蜴胃康基本方治疗慢性萎缩性胃炎气阴不足、毒瘀交阻证临床研究

发布时间：2018-10-10 11:43

【摘要】：目的在证候聚类分析的基础上,观察蜥蜴胃康基本方治疗慢性萎缩性胃炎(Chronic Atrophic Gastritis,CAG)气阴不足、毒瘀交阻证的临床疗效,并观察其安全性和不良反应。方法收集2014年1月至2015年12月宁夏医科大学附属回医中医医院国家中医药管理局脾胃病重点学科门诊89例经胃镜及病理确诊、中医辨证为气阴不足、毒瘀交阻证的CAG患者,随机分为治疗组45例和对照组44例,治疗组采用蜥蜴胃康基本方(宁夏密点麻蜥、太子参、黄芪、石斛、乌梅、炒白芍、半枝莲、蛇莓、三七、枳壳、甘草等,由宁夏医科大学附属回医中医医院提供)治疗,每日一剂,水煎三次浓缩为200ml,饭后2h服用,3/日;对照组口服养胃颗粒,每次2袋,3/日。12周疗程结束后进行两组临床疗效评价。结果治疗组总有效率为93.33%,对照组总有效率为72.73%,两组比较P0.05。随访发现治疗组远期疗效较好,且未见不良反应。结论以证候研究为基础的蜥蜴胃康基本方可有效改善CAG黏膜营养,减少萎缩、杀灭幽门螺杆菌(HP),具有较好的临床疗效,证病结合研究是CAG防治的有效方法。
[Abstract]:Objective on the basis of syndrome cluster analysis, to observe the clinical effect of Lianweikang recipe in the treatment of chronic atrophic gastritis (Chronic Atrophic Gastritis,CAG) with deficiency of Qi and yin, toxin and blood stasis, and its safety and adverse reactions. Methods from January 2014 to December 2015, 89 patients with CAG diagnosed by gastroscopy and pathology were collected in the Department of spleen and stomach Disease of the affiliated Huihui traditional Chinese Medicine Hospital of Ningxia Medical University. The treatment group was randomly divided into treatment group (n = 45) and control group (n = 44). The treatment was provided by Hui Medical Hospital affiliated to Ningxia Medical University. Once daily, the decoction was concentrated to 200ml for 3 times, and the control group was treated with Yangwei granules for 2 hours after meals. The control group was treated with Yangwei granules for 2 bags / d. 12 weeks after the course of treatment, the two groups were evaluated for the clinical curative effect. Results the total effective rate was 93.33 in the treatment group and 72.73 in the control group. Follow-up showed that the long-term effect of the treatment group was better, and no adverse reactions. Conclusion based on syndromes study, lizard Weikang decoction can effectively improve CAG mucosal nutrition, reduce atrophy and kill Helicobacter pylori (HP),. The combination of syndromes and diseases is an effective method for the prevention and treatment of CAG.
【作者单位】：宁夏医科大学;宁夏医科大学附属回医中医医院;宁夏医科大学总医院;
【基金】：国家自然科学基金(No.81560769) 宁夏自然科学基金(No.NZ15089) 宁夏高等学校科学研究项目(No.NGY2014096)
【分类号】：R259

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