益肾理血方治疗肾虚血瘀型免疫性不孕症的临床观察

发布时间：2018-10-10 12:51

【摘要】：目的:益肾理血方是王秀霞教授在临床中用于治疗免疫性不孕症的有效方剂。本文通过临床观察益肾理血方对不孕四项转阴情况、妊娠率和中医临床症状改善情况的影响,探讨益肾理血方治疗肾虚血瘀型免疫性不孕症(四项抗体阳性)的临床疗效,为其应用提供依据。方法:本课题选择治疗前后对照研究的方式,将收集到的与纳入和排除标准相符的75例肾虚血瘀型免疫性不孕症患者,给予益肾理血方服用,每日1剂,早晚饭后温服。每个疗程为期1个月,共治疗3个疗程。每个疗程结束后,检测(采用酶联免疫吸附试验)患者血清中AsAb、EmAb、AcAb、AoAb的含量。未转阴者和转阴后复发者进入下一疗程治疗,若转阴者则需进行巩固治疗半个月。停药后随访半年,观察妊娠情况、中医临床症状改善情况及临床综合疗效情况。结果采用统计软件SPSS17.0统计分析。结果:1、经3个疗程治疗后,中医症候临床疗效的总有效率是84.00%。治疗前后中医症状总积分及各单项症状积分进行对比,经两配对样本非参数检验分析,均P0.01,具有统计学意义。2、经治疗后,AsAb、AcAb、EmAb、AoAb转阴率经过X2检验,差异均具有统计学意义(P0.01)。3、经治疗后,患者妊娠率为65.33%。4、统计并分析数据可知疾病总有效率为90.67%。以上结果均说明,益肾理血方对于肾虚血瘀型免疫性不孕症的治疗效果较好。结论:1、益肾理血方能够有效促进肾虚血瘀型免疫性不孕症患者血清中AsAb、EmAb、AcAb、AoAb转阴,改善妊娠情况。2、益肾理血方能有效改善或消除免疫性不孕症患者肾虚血瘀的临床症状,降低中医症状积分。3、益肾理血方是治疗肾虚血瘀型免疫性不孕症效果确切的方剂之一。
[Abstract]:Objective: Yishen Lixue prescription is an effective prescription for the treatment of immune infertility by Professor Wang Xiuxia. Through clinical observation of the effects of Yishen Lixue recipe on the negative conversion of infertility, pregnancy rate and the improvement of clinical symptoms of TCM, the clinical efficacy of Yishen Lixue recipe in treating immune infertility with kidney deficiency and blood stasis type (positive for four antibodies) was discussed. To provide the basis for its application. Methods: in this study, 75 cases of immune infertility with kidney deficiency and blood stasis were treated with Yishen Lixue recipe, 1 dose per day, and 1 dose per day, after morning and evening, which were consistent with the standard of inclusion and exclusion, and 75 cases of immune infertility with deficiency of kidney and blood stasis were selected as control study before and after treatment. Each course of treatment lasted for 1 month, a total of 3 courses of treatment. At the end of each course, serum AsAb,EmAb,AcAb,AoAb levels were measured (using enzyme-linked immunosorbent assay (Elisa). Those who did not turn negative and recrudesced after turning negative entered the next course of treatment, and those who turned negative needed to be consolidated for half a month. Follow up for half a year, observe pregnancy, improve clinical symptoms of TCM and clinical comprehensive curative effect. Results Statistical software SPSS17.0 was used for statistical analysis. Results: 1, after three courses of treatment, the total effective rate of clinical curative effect of TCM symptom was 84.00. Before and after treatment, the total score of TCM symptoms and the scores of individual symptoms were compared. The results of non-parametric analysis of two paired samples showed that there was statistical significance. 2. After treatment, the negative rate of AsAb,AcAb,EmAb,AoAb was tested by X2 test. The difference was statistically significant (P0.01). 3 after treatment, the pregnancy rate of the patients was 65.33 and .4.The total effective rate of the disease was 90.67. The above results indicate that Yishen Lixue prescription is effective in the treatment of immune infertility with kidney deficiency and blood stasis. Conclusion: 1. Yishen Lixue prescription can effectively promote AsAb,EmAb,AcAb,AoAb negative in serum of patients with immune infertility with kidney deficiency and blood stasis, and improve pregnancy. 2. Yishen Lixue prescription can effectively improve or eliminate the clinical symptoms of kidney deficiency and blood stasis in immune infertility. Reduce TCM symptom score. 3, Yishen Lixue prescription is one of the exact prescriptions for the treatment of immune infertility due to kidney deficiency and blood stasis.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.14

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