解郁清肝安神饮治疗肝郁化火型失眠症临床观察
发布时间：2018-10-12 14:59
【摘要】：目的:运用随机对照的方法,以阿普唑仑片为对照药物,通过观察治疗前后的匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)积分、多导睡眠图(Polysomnogram,PSG)参数的变化情况,评价解郁清肝安神饮治疗肝郁化火型失眠症的临床疗效和安全性,并从临床角度分析其治疗肝郁化火型失眠症的优势,为其临床应用提供科学的依据。方法:选择自2015年4月~2016年2月在河南省中医院脑病科门诊就诊的失眠症患者62例,按随机数字表法将其分为治疗组与对照组,两组各31例。治疗组应用解郁清肝安神饮,由河南省中医院煎药室自动煎药机煎煮,每剂煎2袋,200ml/袋,每天服2袋,早晚饭后半小时各温服1袋;对照组应用阿普唑仑片,每次0.4mg,睡前半小时服用。两组疗程均为4周。治疗前、疗程结束后各观察两组PSQI积分、PSG参数的变化情况,并评价两组的临床疗效和安全性。数据应用SPSS20.0软件进行分析。结果:1.PSQI评定结果:两组PSQI总分及各单项积分较治疗前均有降低(P值均0.05);治疗后两组间比较,在PSQI总分上无统计学意义(P0.05),各单项积分比较,在日间功能这一方面,治疗组优于对照组(P0.05)。说明在改善患者总体睡眠状况上,两组治疗方法效果相当,治疗组的治疗方法能更好的改善患者日间功能。2.PSG评定结果:两组睡眠潜伏期(Sleep latency,SL)较治疗前均减少,总睡眠时间(Total sleep time,TST)均增加,差异均有统计学意义(P值均0.05);治疗后两组间比较,在SL、TST上,差异均无统计学意义(P值均0.05)。治疗组N1期比例较治疗前减少(P0.05),对照组N1期比例与治疗前相比差异无统计学意义(P0.05);治疗组N2期比例较治疗前减少(P0.05),对照组N2期比例较治疗前增加(P0.05);治疗组N3期比例较治疗前增加(P0.05),对照组N3期比例较治疗前减少(P0.05);治疗后两组间比较,在N1、N2、N3期比例改善情况上,治疗组均优于对照组(P值均0.05)。说明在改善SL和TST上,两组的治疗方法效果相当;在非快速眼动睡眠(Non-Rapid Eye Movement,NREM)各期比例变化情况上,治疗组的治疗方法能减少N1、N2期浅睡眠,增加N3期深睡眠,对照组的治疗方法能增加N2期浅睡眠,减少N3期深睡眠。3.疗效评定结果:治疗组痊愈6例,显效12例,有效9例,无效4例,总有效率为87.10%;对照组痊愈5例,显效8例,有效12例,无效6例,总有效率为80.65%;治疗组与对照组疗效相当(P0.05)。结论:1.解郁清肝安神饮治疗肝郁化火型失眠症疗效与阿普唑仑相当。2.解郁清肝安神饮能有效的改善患者的总体睡眠状况,且能较好的改善患者日间功能状态。3.解郁清肝安神饮能缩短患者的SL,增加TST,且能改善睡眠结构,减少N1、N2期浅睡眠,增加N3期深睡眠。4.解郁清肝安神饮在治疗过程中未见任何不良反应,是治疗肝郁化火型失眠症的安全有效药物。
[Abstract]:Objective: to observe the changes of Pittsburgh sleep quality index (Pittsburgh sleep quality index,PSQI) and polysomnography (Polysomnogram,PSG) parameters before and after treatment with alprazolam tablets. To evaluate the clinical efficacy and safety of Jieyu Qinggan Anshen decoction in treating insomnia of the type of liver depression and fire, and to analyze its advantages in the treatment of insomnia of the type of liver depression and fire from the clinical point of view, and to provide scientific basis for its clinical application. Methods: from April 2015 to February 2016, 62 patients with insomnia were selected and divided into treatment group (n = 31) and control group (n = 31). The treatment group was treated with Jieyu Qinggan Anshen decoction, which was prepared by automatic decoction machine in the decoction Room of Henan traditional Chinese Medicine Hospital, with 2 bags per dose, 200ml/ bag, 2 bags a day, 1 bag each half an hour after morning and evening, while the control group was treated with alprazolam tablets, and the control group was treated with alprazolam tablets. Take 0.4 mg each time, half an hour before bedtime. The course of treatment was 4 weeks in both groups. Before and after treatment, the changes of PSQI scores and PSG parameters were observed, and the clinical efficacy and safety of the two groups were evaluated. The data is analyzed by SPSS20.0 software. Results: the results of 1.PSQI evaluation showed that the total score and individual score of PSQI in the two groups were lower than those before treatment (P < 0. 05), but there was no significant difference in the total score of PSQI between the two groups after treatment (P0.05), and there was no significant difference in the total score of PSQI between the two groups (P0.05). The treatment group was superior to the control group (P0.05). The results showed that the two groups had the same effect in improving the overall sleep status, and the treatment methods in the treatment group could better improve the daytime function of the patients. The results of 2.PSG evaluation showed that the sleep latency (Sleep latency,SL) of the two groups was lower than that of before treatment. The total sleep time (Total sleep time,TST) increased and the difference was statistically significant (P < 0. 05), but there was no significant difference in SL,TST between the two groups after treatment (P < 0. 05). The proportion of N1 phase in treatment group was lower than that before treatment (P0.05), the proportion of N1 phase in control group was not significantly different from that before treatment (P0.05), the proportion of N2 phase in treatment group was lower than that before treatment (P0.05), the proportion of N2 phase in control group was higher than that before treatment (P0.05), and the ratio of N2 phase in treatment group was higher than that before treatment (P0.05). The proportion of N3 phase in the control group was lower than that before treatment (P0.05), and the ratio between the two groups after treatment was higher than that before treatment (P0.05). The ratio of N _ 1 and N _ 2N _ 3 in the treatment group was better than that in the control group (P < 0.05). The results showed that the two groups had the same effect in improving SL and TST, and in the case of non-rapid eye movement sleep (Non-Rapid Eye Movement,NREM), the treatment methods of the treatment group could reduce the N _ 1N _ 2 shallow sleep and increase the N _ 3 deep sleep. The treatment of control group can increase N 2 shallow sleep and reduce N 3 deep sleep. Results: in the treatment group, 6 cases were cured, 12 cases were effective, 9 cases were effective, 4 cases were ineffective, and the total effective rate was 87.101.In the control group, 5 cases were cured, 8 cases were effective, 12 cases were effective, 6 cases were ineffective, and the total effective rate was 80.65. The curative effect of the treatment group was similar to that of the control group (P0.05). Conclusion: 1. The curative effect of Jieyu Qinggan Anshen decoction in treating insomnia of the type of liver depression and fire was equivalent to alprazolam. 2. 2. Jieyu Qinggan Anshen decoction can effectively improve the overall sleep status of patients, and can better improve the daytime function of patients. 3. Jieyu Qinggan Anshen decoction could shorten SL, and increase TST, improve sleep structure, decrease shallow sleep in N _ 1 / N _ 2 stage, and increase deep sleep in N _ 3 phase. 4. Jieyu Qinggan Anshen Yin is a safe and effective drug for the treatment of liver-depression and fire insomnia.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23
本文编号：2266571
[Abstract]:Objective: to observe the changes of Pittsburgh sleep quality index (Pittsburgh sleep quality index,PSQI) and polysomnography (Polysomnogram,PSG) parameters before and after treatment with alprazolam tablets. To evaluate the clinical efficacy and safety of Jieyu Qinggan Anshen decoction in treating insomnia of the type of liver depression and fire, and to analyze its advantages in the treatment of insomnia of the type of liver depression and fire from the clinical point of view, and to provide scientific basis for its clinical application. Methods: from April 2015 to February 2016, 62 patients with insomnia were selected and divided into treatment group (n = 31) and control group (n = 31). The treatment group was treated with Jieyu Qinggan Anshen decoction, which was prepared by automatic decoction machine in the decoction Room of Henan traditional Chinese Medicine Hospital, with 2 bags per dose, 200ml/ bag, 2 bags a day, 1 bag each half an hour after morning and evening, while the control group was treated with alprazolam tablets, and the control group was treated with alprazolam tablets. Take 0.4 mg each time, half an hour before bedtime. The course of treatment was 4 weeks in both groups. Before and after treatment, the changes of PSQI scores and PSG parameters were observed, and the clinical efficacy and safety of the two groups were evaluated. The data is analyzed by SPSS20.0 software. Results: the results of 1.PSQI evaluation showed that the total score and individual score of PSQI in the two groups were lower than those before treatment (P < 0. 05), but there was no significant difference in the total score of PSQI between the two groups after treatment (P0.05), and there was no significant difference in the total score of PSQI between the two groups (P0.05). The treatment group was superior to the control group (P0.05). The results showed that the two groups had the same effect in improving the overall sleep status, and the treatment methods in the treatment group could better improve the daytime function of the patients. The results of 2.PSG evaluation showed that the sleep latency (Sleep latency,SL) of the two groups was lower than that of before treatment. The total sleep time (Total sleep time,TST) increased and the difference was statistically significant (P < 0. 05), but there was no significant difference in SL,TST between the two groups after treatment (P < 0. 05). The proportion of N1 phase in treatment group was lower than that before treatment (P0.05), the proportion of N1 phase in control group was not significantly different from that before treatment (P0.05), the proportion of N2 phase in treatment group was lower than that before treatment (P0.05), the proportion of N2 phase in control group was higher than that before treatment (P0.05), and the ratio of N2 phase in treatment group was higher than that before treatment (P0.05). The proportion of N3 phase in the control group was lower than that before treatment (P0.05), and the ratio between the two groups after treatment was higher than that before treatment (P0.05). The ratio of N _ 1 and N _ 2N _ 3 in the treatment group was better than that in the control group (P < 0.05). The results showed that the two groups had the same effect in improving SL and TST, and in the case of non-rapid eye movement sleep (Non-Rapid Eye Movement,NREM), the treatment methods of the treatment group could reduce the N _ 1N _ 2 shallow sleep and increase the N _ 3 deep sleep. The treatment of control group can increase N 2 shallow sleep and reduce N 3 deep sleep. Results: in the treatment group, 6 cases were cured, 12 cases were effective, 9 cases were effective, 4 cases were ineffective, and the total effective rate was 87.101.In the control group, 5 cases were cured, 8 cases were effective, 12 cases were effective, 6 cases were ineffective, and the total effective rate was 80.65. The curative effect of the treatment group was similar to that of the control group (P0.05). Conclusion: 1. The curative effect of Jieyu Qinggan Anshen decoction in treating insomnia of the type of liver depression and fire was equivalent to alprazolam. 2. 2. Jieyu Qinggan Anshen decoction can effectively improve the overall sleep status of patients, and can better improve the daytime function of patients. 3. Jieyu Qinggan Anshen decoction could shorten SL, and increase TST, improve sleep structure, decrease shallow sleep in N _ 1 / N _ 2 stage, and increase deep sleep in N _ 3 phase. 4. Jieyu Qinggan Anshen Yin is a safe and effective drug for the treatment of liver-depression and fire insomnia.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23
【相似文献】
相关期刊论文 前7条
1 闫冬梅,张华荣,郝玲,朱彦;滋清安神饮治疗妇女更年期综合征275例[J];江苏中医;1997年12期
2 王志红;;安神饮合益聪浆对失眠患者睡眠质量及焦虑抑郁状态的影响[J];时珍国医国药;2007年03期
3 卓志明;邹锦山;陈丽娟;;百麦安神饮对广泛性焦虑障碍的辅助治疗作用[J];临床精神医学杂志;2010年05期
4 岳金凤;;分清症状治失眠[J];百姓生活;2011年03期
5 王志红;;安神饮治疗失眠症192例疗效观察[J];中国中医药信息杂志;2006年02期
6 王志红;安神饮治疗不寐临床体会[J];河北中医;2005年05期
7 ;[J];;年期
相关会议论文 前1条
1 王志红;穆瑞萍;穆炳革;;安神饮合益聪浆对失眠患者睡眠质量、焦虑抑郁状态的影响[A];睡眠研究：传统与现代——第四届全国中医睡眠医学学术研讨会论文集[C];2006年
相关硕士学位论文 前2条
1 胡洋;解郁清肝安神饮治疗肝郁化火型失眠症临床观察[D];河南中医药大学;2016年
2 杨小燕;清中安神饮治疗痰热内扰型失眠的临床研究[D];山东中医药大学;2014年
，本文编号：2266571
本文链接：https://www.wllwen.com/zhongyixuelunwen/2266571.html
最近更新
教材专著
