参附注射液治疗脓毒性休克（阳气暴脱型）的临床观察
发布时间：2018-10-14 14:58
【摘要】：目的:在时间医学因时治疗的理论指导下,择时运用参附注射液治疗脓毒性休克(阳气暴脱型)并观察其临床效果。方法:选取来自于哈尔滨医科大学附属第二医院ICU病房并确诊为脓毒性休克(阳气暴脱型)的患者89例,按随机数字表随机分为四组,分别为对照组、午时组、子时组、辰时组。对照组23例,参附治疗组每组22例。午时组在常规治疗的基础上(11:00-13:00)联合参附注射液治疗;子时组在常规治疗的基础上(23:00-1:00)联合参附注射液治疗;辰时组在常规治疗的基础上(7:00-9:00)联合参附注射液治疗。连续治疗7天后,观察每组患者第 7d 的 SOFA评分(Sequential organ failure assessment score)、降钙素原(Procalcitonin,PCT)、采用全自动生化仪测量的心肌肌钙蛋白I(Cardiac troponin I,cTnI)及血中 B 型尿钠肽(Type B natriuretic petide,BNP)、平均动脉压(Mean artery pressure,MAP)及动脉血乳酸值(Lactic acid,LAC)。四组之间,分别通过两两比较第7d的所观察指标的变化,进行疗效判定。结果:本次研究共有89例患者,在观察过程中脱落9例,期间5例放弃治疗转院;4例因严重感染、多脏器功能衰竭死亡。1.四组患者在基本资料中年龄、体重、APACHEⅡ评分经统计学比较无统计学意义(P0.05);2.SOFA评分的结果显示:与对照组比较,其余三组SOFA评分均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);3.PCT的结果显示:与对照组比较,其余三组PCT均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);4.cTnⅠ的结果显示:与对照组比较,其余三组cTnI均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);5.BNP的结果显示:与对照组比较,其余三组BNP均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);6.MAP的结果显示:与对照组比较,其余三组MAP均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);7.LAC的结果显示:与对照组比较,其余三组LAC均增高;午时组高于子时组、辰时组,辰时组高于子时组,差异具有统计学意义(P0.05);结论:1.基于时间医学择时应用参附注射液联合常规治疗的方法与单纯的常规治疗方法对脓毒性休克(阳气暴脱型)患者都有疗效,但因"时"治疗效果更佳。2.午时组(11:00-13:00)用药,疗效最佳,这可能与机体正盛邪虚有关。
[Abstract]:Objective: to observe the clinical effect of Shenfu injection in the treatment of septic shock. Methods: Eighty-nine patients from ICU ward of the second affiliated Hospital of Harbin Medical University who were diagnosed as septic shock were randomly divided into four groups: control group, midday group and sub-time group. Chen Shi group. 23 cases in control group and 22 cases in each group in Shenfu treatment group. The midday group was treated on the basis of routine treatment (11: 00-13: 00) combined with Shenfu injection, Zishi group (2300-1: 00) combined with Shenfu injection on the basis of routine treatment, and Chenshi group was treated with Shenfu injection on the basis of routine treatment (7: 00-9: 00). After seven consecutive days of treatment, The SOFA scores of (Sequential organ failure assessment score), procalcitonin (Procalcitonin,PCT) were measured on the 7th day of each group. Cardiac troponin (I (Cardiac troponin I), type B urinary natriuretic peptide (Type B natriuretic petide,BNP), mean arterial pressure (Mean artery pressure,MAP) and arterial blood lactic acid (Lactic acid,LAC) were measured by automatic biochemical instrument. Among the four groups, the curative effect was evaluated by comparing the changes of the observed indexes on the 7th day. Results: there were 89 patients in this study, 9 cases dropped out during the observation, 5 cases gave up treatment and transferred to hospital, 4 cases died of multiple organ failure due to severe infection. 1. The age, weight and APACHE 鈪，
本文编号：2270815
[Abstract]:Objective: to observe the clinical effect of Shenfu injection in the treatment of septic shock. Methods: Eighty-nine patients from ICU ward of the second affiliated Hospital of Harbin Medical University who were diagnosed as septic shock were randomly divided into four groups: control group, midday group and sub-time group. Chen Shi group. 23 cases in control group and 22 cases in each group in Shenfu treatment group. The midday group was treated on the basis of routine treatment (11: 00-13: 00) combined with Shenfu injection, Zishi group (2300-1: 00) combined with Shenfu injection on the basis of routine treatment, and Chenshi group was treated with Shenfu injection on the basis of routine treatment (7: 00-9: 00). After seven consecutive days of treatment, The SOFA scores of (Sequential organ failure assessment score), procalcitonin (Procalcitonin,PCT) were measured on the 7th day of each group. Cardiac troponin (I (Cardiac troponin I), type B urinary natriuretic peptide (Type B natriuretic petide,BNP), mean arterial pressure (Mean artery pressure,MAP) and arterial blood lactic acid (Lactic acid,LAC) were measured by automatic biochemical instrument. Among the four groups, the curative effect was evaluated by comparing the changes of the observed indexes on the 7th day. Results: there were 89 patients in this study, 9 cases dropped out during the observation, 5 cases gave up treatment and transferred to hospital, 4 cases died of multiple organ failure due to severe infection. 1. The age, weight and APACHE 鈪，
本文编号：2270815
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