咽部刺营疗法治疗慢性咽炎的临床与实验研究
发布时间：2018-10-14 19:33
【摘要】：目的探究咽部刺营疗法治疗慢性咽炎的临床效果。观察咽部刺营法对慢性咽炎模型动物的咽部病理形态学影响。方法1临床研究将120例慢性咽炎患者按1:1比例随机分为咽部刺营观察组和西药对照组。观察组采用咽部刺营疗法治疗;对照组采用头孢地尼胶囊口服。两组均治疗2个疗程,观察两组的治疗效果并做统计学处理。对参加试验的所有病例,在治疗前后检测血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平,观察其变化并做统计学处理。2实验研究将50只新西兰兔随机分为5组,每组10只:A组为咽部刺营疗法组,B组为单纯模型组,C组为利咽合剂治疗组,D组为空白对照组,E组为自然恢复组。A、B、C、E组动物均建立慢性咽炎模型。造模完成后,处死单纯模型组动物;A组动物行咽部刺营治疗,C组动物以利咽合剂给药治疗,D组动物以蒸馏水局部喷雾为对照,E组动物不予治疗。各组动物处死后,立即取下咽部黏膜组织切片观察。结果1临床研究结果(1)选取的观察组、治疗组患者的性别、年龄及病程长短无统计学差异。(2)治疗2个疗程后,观察组治愈33例,显效22例,无效5例,总有效率91.67%;对照组治愈20例,显效21例,无效19例,总有效率68.33%。观察组治疗后的有效率明显高于西药对照组,差异有统计学意义(P0.05)。(3)观察组、对照组的各项症状体征均较治疗前显著改善,而观察组在改善症状体征方面更优于对照组,差异具有统计学意义(P0.05)。(4)治疗后两组血清IL-2、TNF-α均较治疗前显著改善,且对照组的改善程度不及观察组,差异具有统计学意义(P0.05)。2实验研究结果(1)咽部刺营疗法组的模型动物经过治疗后,饮食、饮水均较治疗前增多,活动量逐渐增多,精神状态也较前好转。(2)病理形态学观察结果显示,慢性咽炎的模型动物通过咽部刺营疗法治疗后,有3只兔咽部黏膜病理形态恢复正常,7只兔有轻度炎症、水肿或充血。结论(1)临床研究结论临床观察显示,咽部刺营疗法能明显改善慢性咽炎患者临床症状;咽部刺营疗法在临床应用过程中安全有效、无毒副作用。(2)实验研究结论动物实验研究表明,咽部刺营法可有效改善咽部炎性细胞浸润,减轻血管充血,缓解黏膜肿胀。
[Abstract]:Objective to explore the clinical effect of treating chronic pharyngitis with pharynx acupuncture-ying therapy. To observe the pathomorphology of pharynx of chronic pharyngitis model animal treated with pharynx needling-ying method. Methods 1 120 patients with chronic pharyngitis were randomly divided into the observation group and the control group at 1:1. The observation group was treated with pharyngeal needling and the control group was treated with cefdinil capsule. The two groups were treated for 2 courses. The therapeutic effects of the two groups were observed and statistically analyzed. The serum levels of interleukin-2 (IL-2) and tumor necrosis factor- 伪 (TNF- 伪) were measured before and after treatment. There were 10 rats in each group: group A was treated with pharynx needling, group B was simple model group, group C was treated with Liyan mixture, group D was blank control group, group E was natural recovery group. After the model was made, the simple model group was killed, the animals in group A were treated with pharynx needling, the animals in group C were treated with Liyan mixture, the animals in group D were treated by local spray of distilled water, and the animals in group E were not treated. After the animals were killed, the mucosal sections of hypopharynx were taken and observed immediately. Results (1) there was no significant difference in sex, age and course of disease between the two groups. (2) after two courses of treatment, 33 cases were cured, 22 cases were markedly effective, 5 cases were ineffective in the observation group. The total effective rate was 91.67. In the control group, 20 cases were cured, 21 cases were markedly effective, 19 cases were ineffective, and the total effective rate was 68.33. The effective rate after treatment in the observation group was significantly higher than that in the western medicine control group, the difference was statistically significant (P0.05). (3). The symptoms and signs of the control group were significantly improved than those of the control group, and the observation group was better than the control group in improving the symptoms and signs. The difference was statistically significant (P0.05). (4) after treatment, the serum IL-2,TNF- 伪 of the two groups were significantly improved compared with those of the control group, and the improvement degree of the control group was not as good as that of the observation group. The difference was statistically significant (P0.05). 2 results (1) after treatment, the diet and drinking water of the model animals in the pharynx needling group increased, and the activity increased gradually. (2) the results of pathomorphological observation showed that after the treatment of chronic pharyngitis, 3 rabbits had normal morphology of pharyngeal mucosa, 7 rabbits had mild inflammation, edema or hyperemia. Conclusion (1) Clinical observation shows that pharynx needling therapy can obviously improve the clinical symptoms of patients with chronic pharyngitis, and it is safe and effective in clinical application. (2) No toxic side effects. (2) the animal experimental study showed that pharynx needling can effectively improve the infiltration of inflammatory cells in the pharynx, reduce blood vessel congestion, and alleviate mucosal swelling.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R276.1
本文编号：2271431
[Abstract]:Objective to explore the clinical effect of treating chronic pharyngitis with pharynx acupuncture-ying therapy. To observe the pathomorphology of pharynx of chronic pharyngitis model animal treated with pharynx needling-ying method. Methods 1 120 patients with chronic pharyngitis were randomly divided into the observation group and the control group at 1:1. The observation group was treated with pharyngeal needling and the control group was treated with cefdinil capsule. The two groups were treated for 2 courses. The therapeutic effects of the two groups were observed and statistically analyzed. The serum levels of interleukin-2 (IL-2) and tumor necrosis factor- 伪 (TNF- 伪) were measured before and after treatment. There were 10 rats in each group: group A was treated with pharynx needling, group B was simple model group, group C was treated with Liyan mixture, group D was blank control group, group E was natural recovery group. After the model was made, the simple model group was killed, the animals in group A were treated with pharynx needling, the animals in group C were treated with Liyan mixture, the animals in group D were treated by local spray of distilled water, and the animals in group E were not treated. After the animals were killed, the mucosal sections of hypopharynx were taken and observed immediately. Results (1) there was no significant difference in sex, age and course of disease between the two groups. (2) after two courses of treatment, 33 cases were cured, 22 cases were markedly effective, 5 cases were ineffective in the observation group. The total effective rate was 91.67. In the control group, 20 cases were cured, 21 cases were markedly effective, 19 cases were ineffective, and the total effective rate was 68.33. The effective rate after treatment in the observation group was significantly higher than that in the western medicine control group, the difference was statistically significant (P0.05). (3). The symptoms and signs of the control group were significantly improved than those of the control group, and the observation group was better than the control group in improving the symptoms and signs. The difference was statistically significant (P0.05). (4) after treatment, the serum IL-2,TNF- 伪 of the two groups were significantly improved compared with those of the control group, and the improvement degree of the control group was not as good as that of the observation group. The difference was statistically significant (P0.05). 2 results (1) after treatment, the diet and drinking water of the model animals in the pharynx needling group increased, and the activity increased gradually. (2) the results of pathomorphological observation showed that after the treatment of chronic pharyngitis, 3 rabbits had normal morphology of pharyngeal mucosa, 7 rabbits had mild inflammation, edema or hyperemia. Conclusion (1) Clinical observation shows that pharynx needling therapy can obviously improve the clinical symptoms of patients with chronic pharyngitis, and it is safe and effective in clinical application. (2) No toxic side effects. (2) the animal experimental study showed that pharynx needling can effectively improve the infiltration of inflammatory cells in the pharynx, reduce blood vessel congestion, and alleviate mucosal swelling.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R276.1
【参考文献】
相关期刊论文 前10条
1 洪国灿;蔡真真;胡维;;少商、商阳穴放血在急性扁桃体炎的临床研究[J];光明中医;2016年24期
2 闫春迪;杨继国;;针刺放血治疗小儿扁桃体炎15例临床体会[J];亚太传统医药;2016年23期
3 康志;马春花;刘海永;白荟芳;;针刺伏兔配委中放血疗法治疗急性腰扭伤的初步效果[J];中国医药导报;2016年34期
4 李庆祥;;刺络放血法治疗带状疱疹26例[J];中国中医药现代远程教育;2016年20期
5 王文艳;康熙雄;吴中朝;王彤;王京京;陈仲杰;郑楚;;针刺放血治疗瘀血型腰椎间盘突出症的临床观察[J];中国中医基础医学杂志;2016年09期
6 朱志强;;刺络放血治疗带状疱疹后遗神经痛的疗效观察[J];中国实用神经疾病杂志;2016年13期
7 侯莉;;庆大霉素雾化吸入治疗慢性咽炎效果观察[J];中外医学研究;2016年17期
8 朱丽明;那学武;李海洲;孙建华;;鼻内镜手术治疗鼻源性慢性咽炎的临床效果观察[J];中国医药指南;2016年15期
9 金炜;;放血疗法肝阳上亢型高血压32例疗效探讨[J];中外医疗;2016年08期
10 郭会丽;刘俊杰;赵艳丽;;中西医结合治疗慢性咽炎104例临床疗效观察[J];中医临床研究;2016年02期
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