化瘀祛湿方治疗膝骨关节炎早期的临床观察

发布时间：2018-10-14 19:51

【摘要】：目的:探讨和分析化瘀祛湿方治疗膝骨关节炎早期(Early Knee Osteoarthritis,KOA)的临床疗效研究。方法:按照病例纳入标准选择广西中医药大学第一附属医院骨三科门诊就诊的膝骨关节炎早期患者60例,随机分为治疗组30例和对照组30例,治疗组:对照组=1:1。治疗组予以化瘀祛湿方口服,对照组予以双醋瑞因胶囊口服,整个疗程为12周。采用国际公认的Lequesne指数和视觉模拟评分法(VAS)进行评估,观察服药前后临床疗效。结果:Lequesne指数,两组治疗前后自身前后对照,治疗组:2周后:P=0.9860.05,无统计学意义;4周后:P=0.0230.05,有统计学意义;12周后:P=0.0000.01,有显著统计学意义。对照组:2周后:P=0.2120.05,无统计学意义;4周后:P=0.0130.05,有统计学意义;12周后:P=0.0000.01,有显著统计学意义。组间比较:4周后:P=0.9240.05,无统计学意义;12周后:P=0.1280.05,无统计学意义。治疗组总有效数为28例,无效2例,总有效率为93.33%;对照组总有效数为27例,无效3例,总有效率为90.00%,两组在改善膝关节功能方面无显著差异(P0.05)。VAS评分,两组治疗前后自身前后对照,治疗组:2周后:P=0.0790.05,无统计学意义;4周后:P=0.0350.05,有统计学意义;12周后:P=0.0000.01,有显著统计学意义。对照组:2周后:P=0.120.05,无统计学意义;4周后:P=0.0290.05,有统计学意义;12周后:P=0.0000.01,有显著统计学意义。组间比较:4周后:P=0.4340.05,无统计学意义;12周后:P=0.5690.05,无统计学意义。治疗组总有效数为27例,无效3例,总有效率为90.00%;对照组总有效数为26例,无效4例,总有效率为86.67%,两组在改善膝关节疼痛上无显著差异(P0.05)。结论:化瘀祛湿方治疗早期膝骨关节炎所出现的症状上,可以改善患者膝关节的功能,减轻疼痛,与双醋瑞因胶囊治疗疗效无显著差异。
[Abstract]:Objective: to investigate and analyze the clinical curative effect of Huayu Qisheng prescription (Huayu Qisheng Fang) on early (Early Knee Osteoarthritis,KOA of knee osteoarthritis. Methods: according to the criteria of case inclusion, 60 patients with early knee osteoarthritis were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Huayu Qishi prescription and the control group was treated with diacetate Ruiyin capsule for 12 weeks. The internationally recognized Lequesne index and visual analogue score (VAS) were used to evaluate the clinical efficacy before and after treatment. Results: Lequesne index before and after treatment was significantly higher in the treatment group than that in the control group. In the treatment group, there was no significant difference between the two groups after 2 weeks (P < 0.05), after 4 weeks (P < 0.05), and after 12 weeks (P = 0.0000.01). Control group: after 2 weeks: Pao 0.2120.05, no statistical significance; 4 weeks later: Pu 0.0130.05, with statistical significance; 12 weeks after: Pu 0.0000.01, there was significant statistical significance. Comparison between groups: after 4 weeks, there was no statistical significance in Pao 0.9240.05, and after 12 weeks, there was no statistical significance in PX 0.1280.05. The total effective number of 28 cases, ineffective 2 cases, total effective rate 93.33 in the treatment group, 27 cases in the control group, 3 cases in the control group and 90.00000 in the total effective rate, there was no significant difference in improving the knee joint function between the two groups (P0.05). VAS score). Two groups before and after treatment, the treatment group: 2 weeks later: Pu 0.079 0.05, no statistical significance; 4 weeks later: Pu 0.0350.05, with statistical significance; 12 weeks later: Pu 0.0000.01, with significant statistical significance. Control group: after 2 weeks: Pao 0.120.05, no statistical significance; 4 weeks later: Pu 0.0290.05, with statistical significance; 12 weeks after: Pu 0.0000.01, there was significant statistical significance. Comparison between groups: after 4 weeks, there was no statistical significance in Pao 0.4340.05, and after 12 weeks, there was no statistical significance in Pao 0.5690.05. The total effective number was 27 cases, ineffective 3 cases, total effective rate 90.005 in the treatment group, 26 cases in the control group and 4 cases in the control group, the total effective rate was 86.677.There was no significant difference between the two groups in improving the knee joint pain (P0.05). Conclusion: Huayu Qishi prescription can improve the function of knee joint and relieve pain in the treatment of early knee osteoarthritis.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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