化浊安神方治疗原发性失眠痰热扰心证的临床研究

发布时间：2018-10-16 09:15

【摘要】：目的:通过对化浊安神方治疗原发性失眠痰热扰心证的临床观察,为中医药治疗此类疾病提供新思路,并从血浊理论的角度对该病病因病机以及治法方药进行探讨。方法:选取来自山东中医药大学附属医院脑病科门诊,符合筛选条件的原发性失眠痰热扰心证的患者60例,随机分为两组,每组30例。分别标记为试验组和对照组。两组在进行临床观察前在性别、年龄、失眠严重程度、匹兹堡睡眠质量指数、中医证候评分上均无显著性差异(P0.05)。试验组予以化浊安神方,对照组予以黄连温胆汤方,必要时予以西药暂时治疗。服用3周药物后,停药1周后,分别观察其治疗前后失眠改善程度、中医证候评分、匹兹堡睡眠质量指数的变化。结果:服用3周药物后,停药1周观察:1.试验组和对照组患者中医证候均得到改善,且试验组较对照组明显占优势(P0.01);2.试验组和对照组患者主观睡眠时间均有所延长,试验组主观入睡时间延长优于对照组(P0.01);3.试验组和对照组患者入睡所需时间均有所缩短,试验组入睡所需时间明显少于对照组(P0.01);4.试验组和对照组患者临床症状均得到改善,且试验组临床症状改善情况明显优于对照组(P0.01)。5.在试验组与对照组服用药物过程中,两组患者均未出现明显重大不良事件,安全性指标检查未出现异常。结论:化浊安神方对改善原发性失眠痰热扰心证有较好的效果,可改善患者中医证候、减少患者入睡时间、增加主观睡眠时间、提升睡眠质量,且无不良反应。
[Abstract]:Objective: through clinical observation of Huazhuo Anshen prescription in treating primary insomnia and phlegm heat disturbing heart syndrome, to provide a new way for TCM to treat this kind of disease, and to discuss the etiology and pathogenesis of this disease and the prescription of treatment from the point of view of blood turbid theory. Methods: sixty patients with primary insomnia, phlegm and heat disturbance were selected from the Department of Encephalopathy, affiliated Hospital of Shandong University of traditional Chinese Medicine, and were randomly divided into two groups, 30 cases in each group. They were labeled as experimental group and control group respectively. There was no significant difference in sex age insomnia severity Pittsburgh sleep quality index and TCM syndrome score between the two groups before clinical observation (P0.05). The experimental group was treated with Huazhuo Anshen recipe, the control group with Huanglian Wendan decoction, and the control group with temporary treatment with western medicine. After taking drugs for 3 weeks and stopping for 1 week, the improvement degree of insomnia, TCM syndrome score and Pittsburgh sleep quality index were observed before and after treatment. Results: after 3 weeks treatment, 1 week observation: 1. Experimental group and control group patients with TCM syndrome were improved, and the test group was significantly superior to the control group (P0.01); 2. The subjective sleep time of the test group and the control group were prolonged, and the subjective sleep time of the test group was longer than that of the control group (P0.01). The time required to fall asleep in both the experimental group and the control group was shorter than that in the control group (P0.01). The clinical symptoms of both the experimental group and the control group were improved, and the improvement of the clinical symptoms in the experimental group was significantly better than that in the control group (P0.01). There were no significant adverse events and no abnormal safety indexes in both groups. Conclusion: Huazhuo Anshen prescription has good effect on improving the syndrome of phlegm and heat disturbing heart in patients with primary insomnia. It can improve the syndrome of TCM, reduce the time of falling asleep, increase the time of subjective sleep, improve the quality of sleep, and have no adverse reactions.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23

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