宋元时期消渴证治用药规律的隐结构模型评价

发布时间：2018-10-18 08:52

【摘要】：目的评价宋元时期消渴用药规律及证治特点。方法计算机检索《中华医典》宋元时期综合类方书的消渴证治方剂,采用隐结构结合综合聚类模型,构建消渴证治用药规律的隐树结构图,结合隐类概率、条件概率、互信息、信息覆盖率等用药量化数据,人工判读诠释各隐类消渴证治用药规律特征。结果宋元时期消渴证治用药分为11个隐类,分别以天花粉与黄连、熟地与黄芪、肉苁蓉与山茱萸、人参与当归、桑白皮与赤茯苓、知母与麦门冬、泽泻与石脂、鸡内金与生地、五味子与磁石、牡蛎与苦参、龙骨与桑螵蛸为核心代表药物。通过以药测证,宋元时期消渴主要表现为阴虚阳浮证、阴虚毒炽证、阴虚火旺证、阴虚不固证、肝肾阴虚证、气血两虚证、气阴两虚证、湿热血瘀证、水饮内停证、湿浊内阻证等。结论隐结构模型与综合聚类模型结合方法,较适宜于疾病证治用药规律研究,亦可用于辅助验证疾病证候要素研究结果。
[Abstract]:Objective to evaluate the characteristics of antithirst medication in Song and Yuan dynasties. Methods A computer search was conducted to find the prescription for dispelling thirst syndrome in the comprehensive prescriptions of the Song and Yuan dynasties, and to construct the hidden tree structure map of the law of drug use for eliminating thirst syndrome by using the implicit structure combined with the comprehensive cluster model, combining the hidden probability, conditional probability and mutual information. The quantitative data such as information coverage rate were used to interpret and interpret the characteristics of drug use. Results during the Song and Yuan dynasties, the drug used to treat thirst syndrome was divided into 11 hidden categories, which were Trichosanthin and Coptis chinensis, cooked land and Astragalus membranaceus, Cistanche deserticola and Fructus Corni, people involved in angelica sinensis, mulberry white skin and red Poria cocos, Anemarrhena and Ophiopogon, alisma and lipids, chicken gold and raw land. Schisandra and magnetite, oysters and Sophora flavescens, keel and octopus multimaicus are the core drugs. By drug test, the main manifestations of thirst in Song and Yuan dynasties are yin deficiency and yang floating syndrome, yin deficiency and toxin burning syndrome, yin deficiency fire flourishing syndrome, yin deficiency not solid syndrome, liver and kidney yin deficiency syndrome, qi and blood deficiency syndrome, qi and yin deficiency syndrome, damp-heat and blood stasis syndrome, and water drink withholding syndrome. Dampness and turbid internal obstruction, etc. Conclusion the combination of the implicit structure model and the comprehensive cluster model is more suitable for the study of the law of drug use in the treatment of disease syndrome and can also be used to verify the results of the study on the essential factors of disease syndromes.
【作者单位】：陕西中医药大学基础医学院;北京中医药大学东直门医院呼吸科;
【分类号】：R255.4

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