隔药灸脐法治疗排卵障碍性不孕症:随机对照试验

发布时间：2018-10-19 10:48

【摘要】：目的:观察隔药灸脐法与克罗米芬(CC)治疗排卵障碍性不孕症的疗效差异。方法:采用双盲双模拟的随机对照方法,将40名排卵障碍性不孕症患者随机分为隔药灸脐组和克罗米芬组,每组20例。对患者和操作者实施双盲。隔药灸脐组采用隔药灸脐法和口服CC模拟剂的治疗方法,克罗米芬组采用隔模拟剂灸脐法和口服CC的治疗方法。隔药灸脐或隔模拟剂灸脐均在每次月经结束后开始治疗,每周1次,每次施灸1.5 h,月经期不治疗;口服CC或CC模拟剂均自月经来潮第5 d起,口服50 mg CC或CC模拟剂,每日1次,连用5 d。1个月经周期为一疗程,连续治疗3个疗程。3个疗程后,观察两组患者子宫内膜厚度、最大卵泡直径和排卵率,并比较两组的临床疗效。结果:(1)两组子宫内膜厚度治疗后均较治疗前增厚,治疗前后差异有统计学意义(均P0.05);治疗后,隔药灸脐组厚于克罗米芬组,差异有统计学意义(P0.05)。(2)隔药灸脐组最大卵泡直径治疗后较治疗前增大,治疗前后差异有统计学意义(P0.05);克罗米芬组最大卵泡直径治疗后较治疗前增大,但差异无统计学意义(P0.05);治疗后隔药灸脐组最大卵泡直径大于克罗米芬组,差异有统计学意义(P0.05)。(3)治疗后,两组排卵率分别为75.0%(15/20)和65.0%(13/20),差异无统计学意义(P0.05)。(4)隔药灸脐组总有效率为95.0%(19/20),优于克罗米芬组的70.0%(14/20,P0.05)。结论:隔药灸脐法较口服CC临床疗效更好,两组在改善排卵率方面疗效相当。
[Abstract]:Objective: to observe the difference of therapeutic effect between moxibustion and clomiphene (CC) in the treatment of ovulatory dysfunction infertility. Methods: 40 infertile patients with ovulatory disorders were randomly divided into two groups: moxibustion group (n = 20) and clomiphene group (n = 20). Double blindness is applied to patients and operators. Drug separated moxibustion and oral CC analogue were used in moxibustion umbilical group and clomiphene group. Moxibustion and CC were used in clomiphene group. The moxibustion navel or moxibustion omphalus were treated at the end of each menstrual cycle, once a week for 1.5 hours, without treatment during menstrual period. Oral CC or CC mimics were given 50 mg CC or CC analogue from the 5th day of menstrual onset. The endometrial thickness, maximum follicle diameter and ovulation rate of the two groups were observed after 3 courses of treatment, and the clinical effects of the two groups were compared. Results: (1) the thickness of endometrium in the two groups was thicker than that before and after treatment (P0.05), and after treatment, the thickness of moxibustion group was thicker than that of clomiphene group. The difference was statistically significant (P0.05). (2). The maximum follicle diameter of moxibustion group increased after treatment, and the difference before and after treatment was statistically significant (P0.05); the maximum follicle diameter of clomiphene group was larger than that before treatment. But the difference was not statistically significant (P0.05); after treatment, the maximum follicle diameter of moxibustion group was larger than that of clomiphene group, the difference was statistically significant (P0.05). (3) after treatment, The ovulation rates of the two groups were 75.0% (15 / 20) and 65.0% (13 / 20), respectively. The difference was not statistically significant (P0.05). (4). The total effective rate of the moxibustion umbilical group was 95.0% (19 / 20), which was better than that of the clomiphene group (70.0%). Conclusion: herbal moxibustion is more effective than oral CC in improving ovulation rate.
【作者单位】：山东中医药大学;昌邑市昌城医院;山东中医药大学附属医院;山东中医药大学第二附属医院;山东中医药大学针灸推拿学院;
【基金】：山东省科技惠民计划项目:2014kjhm0111 山东省科技发展计划:2014GSF118154
【分类号】：R246.3

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