益气活血法治疗慢性萎缩性胃炎的Meta分析

发布时间：2018-10-20 07:08

【摘要】：目的:评价益气活血法治疗慢性萎缩性胃炎(CAG)的临床疗效及其安全性。方法:应用电子计算机检索Pub Med、相关期刊论文(CNKI)、万方数据库、维普网等数据库,检索时间限定为建库至2016年9月,检索所有具有益气活血功效的中药复方治疗CAG的随机对照试验(RCT),并辅以手工检索相关核心期刊,追索纳入研究的参考文献。由2位评价者根据Cochrane系统评价员手册5.1独立对纳入研究的质量进行严格评价和有效资料提取后,采用RevMan 5.3软件进行Meta分析。结果:最终纳入14项研究,共1 498例患者,分析结果显示:与对照组比较,采用益气活血法能有效提高CAG患者临床总有效率Z=10.01,[OR=5.24,95%CI(3.49,7.25)],P0.0001,差异有统计学意义。此外,在中医症状、胃镜检查、黏膜病理、Hp转阴治疗等方面均显示出较好的临床疗效。但"倒漏斗"图形左右不对称,表明所纳入的研究存在一定的发展偏倚。结论:益气活血法治疗CAG安全有效,值得临床推广,仍需高质量的临床研究进一步支持验证。
[Abstract]:Objective: to evaluate the efficacy and safety of Yiqi Huoxue method in the treatment of chronic atrophic gastritis (CAG). Methods: Pub Med, Chinese periodical full-text database, (CNKI), Wanfang database and Weipu net database were searched by computer. The retrieval time was limited to the period from September 2016 to September 2016. Objective: to search all the randomized controlled trials (RCT),) of traditional Chinese medicine (TCM) for CAG with the effect of replenishing qi and activating blood circulation, and to search the relevant core journals by hand, and to search for the references that were included in the study. According to the Cochrane system evaluator's manual 5.1, two evaluators independently evaluated the quality of the study and extracted the effective data, and then analyzed the Meta with RevMan 5.3 software. Results: 14 studies were carried out and 1 498 patients were included. The results showed that compared with the control group, the total clinical effective rate of CAG patients was improved effectively by the method of supplementing Qi and activating Blood Circulation (OR=5.24,95%CI (3.497.25), and the difference was statistically significant (P 0.0001). In addition, Chinese medicine symptoms, gastroscopy, mucosal pathology, Hp negative treatment and other aspects have shown good clinical efficacy. However, the "inverted funnel" pattern is asymmetrical, which indicates that there is a certain development bias in the research. Conclusion: Yiqi Huoxue therapy is safe and effective in the treatment of CAG.
【作者单位】：中国中医科学院广安门医院;北京中医药大学;
【分类号】：R259

【相似文献】