消痛散外敷治疗癌性疼痛临床疗效研究

发布时间：2018-10-20 08:56

【摘要】：目的:通过对临床病例的观察,总结消痛散外敷治疗癌性疼痛的效果,以及其对患者生活质量的影响,用药安全性问题,综合分析中药外敷法对癌性疼痛的治疗价值。材料与方法:统计了2015年10月到2016年10月于大连市中医医院内四病房住院治疗,符合纳入标准的患者,共计42例。采用随机对照法进行临床研究,将42例病例随机分配到对照组21例,治疗组21例。治疗组与对照组两组同时使用中药(口服汤药、静脉中药)及止痛药。治疗组在此基础上加用消痛散外敷,7天为一疗程,观察记录治疗前后的疼痛缓解程度,生活质量评分、用药安全性等相关数据,对所获得数据运用统计学软件进行统计分析,得出统计结果。结果:本研究纳入患者42例,剔除2例,实际入组40例,治疗组与对照组各20例。治疗组与对照组相比较,不同疼痛程度受试者治疗后疼痛缓解率比较,治疗组与对照组总有效率分别为85%、70%,经统计学分析,说明两组间差异有统计学意义。不同中医证型受试者治疗后疼痛缓解率有明显差异。两组受试者治疗后生活质量积分总有效率比较,治疗组与对照组总有效率分别为90%、65%,经统计学分析,说明两组间差异有统计学意义。治疗组与对照组治疗前后血常规、肝功、肾功变化均不明显,P0.05,说明差异无统计学意义。结论:1.消痛散对不同疼痛程度的癌性疼痛均有疗效,轻度疼痛可单独使用消痛散止痛。2.消痛散对气滞血瘀型、痰湿蕴结型的癌性疼痛疗效显著,对阳虚寒凝型癌性疼痛疗效欠佳,考虑与该证型样本量少有关。3.消痛散能提高患者生活质量。4.消痛散不良反应少,未见明显毒副作用,安全性高。
[Abstract]:Objective: to summarize the effect of external application of Xiaotong Powder on the quality of life of patients with cancerous pain, the safety of drug use, and to analyze the value of external application of traditional Chinese medicine in the treatment of cancer pain through the observation of clinical cases. Materials and methods: from October 2015 to October 2016, 42 patients were admitted in four wards of Dalian traditional Chinese Medicine Hospital. 42 cases were randomly assigned to control group (21 cases) and treatment group (21 cases). The treatment group and the control group were treated with traditional Chinese medicine (oral decoction, intravenous Chinese medicine) and analgesic simultaneously. On this basis, the treatment group was treated with external application of Xiaotong Powder for a course of 7 days. The degree of pain relief, quality of life score, drug safety and other related data before and after treatment were observed and recorded, and the obtained data were statistically analyzed by statistical software. Get the statistical results. Results: 42 cases were included in the study, 2 cases were excluded, 40 cases were actually entered into the group, 20 cases in the treatment group and 20 cases in the control group. Compared with the control group, the total effective rate of the treatment group and the control group was 8570. The statistical analysis showed that the difference between the two groups was statistically significant. There were significant differences in pain relief rate between subjects of different TCM syndromes after treatment. The total effective rate of QOL in the two groups after treatment was 90 and 65, respectively. The statistical analysis showed that the difference between the two groups was statistically significant. The changes of blood routine, liver function and renal function before and after treatment were not obvious in the treatment group and the control group (P 0.05), indicating that there was no significant difference in blood routine test, liver function and renal function before and after treatment. Conclusion: 1. Xiaotong Powder has curative effect on cancer pain of different pain degree, mild pain can be used alone to relieve pain. 2. The curative effect of Xiaotong Powder on cancerous pain of qi stagnation and blood stasis type, phlegm dampness accumulation knot type was remarkable, and the curative effect on Yang deficiency cold coagulation type cancer pain was not good, which was related to the small sample size of this syndrome type. 3. Xiaotong Powder can improve the quality of life of patients. 4. Xiaotongsan has few adverse reactions, no obvious side effects and high safety.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273

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