芪参通络饮对稳定型心绞痛患者（气虚血瘀型）临床疗效观察及对血清GSH-Px、LPO的影响

发布时间：2018-10-24 19:26

【摘要】：目的:本课题观察芪参通络饮对稳定型心绞痛(气虚血瘀型)患者的临床疗效及安全性,并观察芪参通络饮对稳定型心绞痛(气虚血瘀型)患者血清谷胱甘肽过氧化物酶(GSH-Px),过氧化脂质(LPO)水平的影响。方法:本次研究从黑龙江中医药大学附属第一医院心内科门诊共筛选出符合入选标准的60例冠心病稳定型心绞痛患者随机分为治疗组30例和对照组30例,治疗组(芪参通络饮+常规治疗),对照组(常规治疗),观察周期为28天。观察治疗前后临床心绞痛症状,硝酸甘油停减率,中医症候积分及血清谷胱甘肽过氧化物酶(GSH-Px),过氧化脂质(LPO)的含量。结果:1.治疗后治疗组患者临床心绞痛症状疗效总有效率、硝酸甘油停减率分别为90.00%、90.00%,对照组分别为73.33%、70.00%,两组比较均具有统计学意义(P0.05);2.两组治疗后,治疗组治疗症状积分疗效优于对照组(P0.05),在中医症状的改善方面,治疗组相较于对照组有明显的优势(P0.01)。3.治疗组治疗前后对比,血清LPO水平下降,P0.05,差异有统计学意义;血清GSH-Px水平升高,P0.05,差异有统计学意义。结论:1.芪参通络饮能够改善稳定型心绞痛(气虚血瘀型)患者的心绞痛症状和中医证候积分,提高硝酸甘油停减率。2.芪参通络饮能提高患者血清GSH-Px活性以及降低血清LPO水平,减轻心肌氧化应激损伤。
[Abstract]:Objective: to observe the clinical efficacy and safety of Qishen Tongluo decoction in patients with stable angina pectoris (Qi deficiency and blood stasis type). The effects of Qishen Tongluo decoction on serum glutathione peroxidase (GSH-Px) and lipid peroxide (LPO) levels in patients with stable angina pectoris (Qi deficiency and blood stasis type) were observed. Methods: in this study, 60 patients with stable angina pectoris of coronary heart disease were randomly divided into treatment group (n = 30) and control group (n = 30). Treatment group (Qishen Tongluoyin routine treatment), control group (conventional treatment), observation period is 28 days. Symptoms of angina pectoris, stopping rate of nitroglycerin, TCM symptom score, serum glutathione peroxidase (GSH-Px) and lipid peroxide (LPO) content were observed before and after treatment. The result is 1: 1. After treatment, the total effective rate of clinical symptoms of angina pectoris in the treatment group, nitroglycerin stopping and decreasing rate were 90.00and 73.33g respectively. The two groups had statistical significance (P0.05); 2. After treatment, the therapeutic effect of the treatment group was better than that of the control group (P0.05). In the improvement of TCM symptoms, the treatment group had obvious advantages compared with the control group (P0.01). Compared with before and after treatment, serum LPO level decreased, P0.05, the difference was statistically significant, serum GSH-Px level increased, P0.05, the difference was statistically significant. Conclusion: 1. Qishen Tongluo decoction can improve angina symptom and TCM syndromes integral in patients with stable angina pectoris (qi deficiency and blood stasis type) and increase the stopping rate of nitroglycerin. 2. Qishen Tongluo decoction can increase the activity of serum GSH-Px and decrease the level of serum LPO and alleviate myocardial oxidative stress injury.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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