脉血康胶囊对急性脑梗死患者术后凝血功能、血管内皮损伤及血清炎性相关因子的影响

发布时间：2018-10-25 19:51

【摘要】：目的:研究脉血康胶囊对急性脑梗死患者术后凝血功能、血管内皮损伤及血清炎性相关因子的影响。方法:选取2012年7月至2016年2月于本院行选择性动脉溶栓术的119例急性脑梗死患者作为研究对象,按随机数字表法分为观察组58例和对照组61例,对照组给予常规治疗,观察组在对照组治疗基础上口服脉血康胶囊,2组治疗3个月分别检测治疗前后凝血功能指标、血管内皮损伤指标及血清炎性因子水平。结果:观察组总有效率(91.80%)显著高于对照组(70.69%)。治疗前,2组患者的凝血功能和指标(PT、TT、APTT、FIB)、血管内皮损伤(ET-1、TXB_2、NO)及血清炎性因子(IL-6、TNF-α、CRP)水平比较差异有统计学意义。治疗后,观察组的PT、TT、APTT与治疗前比较均显著升高,而FIB较治疗前无显著性变化,其中观察组的PT、TT均显著高于同期的对照组,对照组的PT、TT、APTT和FIB较治疗前无显著性变化,观察组的ET-1和TXB_2较治疗前显著降低,NO较治疗前升高且显著高于同期对照组。对照组的ET-1、TXB_2、NO较治疗前无显著性变化。,观察组的IL-6、TNF-α、CRP较治疗前显著减低且分别显著低于对照组,对照组IL-6、TNF-α较治疗前显著降低。结论:脉血康胶囊对脑梗死患者起到良好的疗效,可有效恢复患者术后凝血功能、血管内皮损伤,有效降低血清炎性因子水平,可作为急性脑梗死患者术后的辅助治疗。
[Abstract]:Aim: to study the effects of Mai Xue Kang capsule on coagulation function, vascular endothelial injury and serum inflammatory related factors in patients with acute cerebral infarction. Methods: 119 patients with acute cerebral infarction who underwent selective thrombolytic thrombolysis from July 2012 to February 2016 were divided into observation group (n = 58) and control group (n = 61). The observation group was treated with Mai Xue Kang capsule on the basis of the control group, and the coagulation function index, vascular endothelial injury index and serum inflammatory factor level were measured before and after treatment for 3 months in the two groups. Results: the total effective rate of the observation group (91.80%) was significantly higher than that of the control group (70.69%). Before treatment, there were significant differences in coagulation function and index (PT,TT,APTT,FIB), vascular endothelial injury (ET-1,TXB_2,NO) and serum inflammatory factor (IL-6,TNF- 伪, CRP) between the two groups. After treatment, the PT,TT,APTT of the observation group was significantly higher than that of the control group, but the FIB had no significant change. The PT,TT of the observation group was significantly higher than that of the control group, and the PT,TT, of the control group was significantly higher than that of the control group. There was no significant change in APTT and FIB. The ET-1 and TXB_2 in the observation group were significantly lower than those before the treatment, and the NO was higher and higher than that in the control group. The IL-6,TNF- 伪 and CRP of the observation group were significantly lower than that of the control group, and the IL-6,TNF- 伪 of the control group was significantly lower than that of the control group. Conclusion: Maixuekang capsule has a good curative effect on patients with cerebral infarction, it can effectively restore the blood coagulation function, vascular endothelial injury, reduce the level of serum inflammatory factors, and can be used as an adjuvant treatment for patients with acute cerebral infarction after operation.
【作者单位】：无锡市中西医结合医院神经内科;
【分类号】：R277.7

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