痤疮合剂对寻常痤疮的疗效观察及对皮肤油脂含量的影响

发布时间：2018-10-26 17:18

【摘要】：目的:观察痤疮合剂对寻常痤疮(肺经风热型)的疗效,并通过检测治疗前后皮肤油脂含量的变化,探讨药物的作用机理。观察可能出现的不良反应,评价其安全性,为本病的治疗提供依据。方法:将寻常痤疮(肺经风热型)患者69例,随机分为治疗组和对照组。实验组35例,予痤疮合剂内服;对照组34例,予复方珍珠暗疮胶囊内服;两组同时外用夫西地酸乳膏;1个疗程共有4周。治疗结束后统计两组患者的临床症状积分、复发情况、不良反应和治疗前后皮肤油脂含量的变化。结果:1.治疗组35例,总有效率为94.29%,其中痊愈4例,显效11例,有效18例,无效2例;对照组34例,总有效率为76.47%,其中痊愈1例,显效4例,有效21例,无效8例。治疗前后两组皮损、中医证候、综合疗效的积分有显著性差异(P0.01),说明在临床疗效方面,两组均效果显著。两组皮损积分、综合疗效积分在疗程结束后比较P0.05,有显著性差异,说明在改善患者皮损、综合疗效方面治疗组优于对照组;中医证候积分比较P0.05,说明痤疮合剂在改善全身症状方面未显出优势。2.治疗组治疗前平均油脂含量为163.44±42.41μg/cm2,对照组治疗前平均油脂含量为161.08±36.74μg/cm2,两组皮肤油脂含量在疗程前后比较P0.01,有显著性差异,说明两组在减少皮肤油脂含量方面都有显著效果。两组皮肤油脂含量在疗程结束后比较P0.05,有显著性差异,说明痤疮合剂在改善患者皮肤油脂含量方面优于对照组。3.安全性结果:对照组治疗期间出现轻度胃肠道反应1例,停药后症状消失。治疗前后检查患者生命体征、肝功能及肾功能检查均未见异常。4.停药随访4周,未发现复发病例。结论:痤疮合剂治疗肺经风热型寻常痤疮疗效明确,不良反应少,复发率低。
[Abstract]:Objective: to observe the curative effect of acne mixture on acne vulgaris (lung meridian wind-heat type), and to explore the mechanism of action by detecting the changes of skin oil content before and after treatment. To observe the possible adverse reactions and evaluate the safety of the disease to provide a basis for the treatment of the disease. Methods: 69 patients with acne vulgaris were randomly divided into treatment group and control group. 35 cases in the experimental group were given acne mixture intravenously, 34 cases in the control group were given the compound pearl dark ulcer capsule, and the two groups were treated externally with Fusidi yoghurt ointment. The course of treatment was 4 weeks. After the treatment, the clinical symptom scores, relapse, adverse reactions and the changes of skin fat content before and after treatment were counted. The result is 1: 1. In the treatment group, the total effective rate was 94.29, in which 4 cases were cured, 11 cases were effective, 18 cases were effective, and 2 cases were ineffective, while in the control group, the total effective rate was 76.477.The total effective rate was 76.477.In which 1 case was cured, 4 cases were markedly effective, 21 cases were effective, and 8 cases were ineffective. Before and after treatment, there were significant differences in the scores of skin lesions, TCM syndromes and comprehensive curative effects between the two groups (P0.01), which indicated that the two groups had a significant effect in terms of clinical efficacy. There was significant difference in the score of skin lesion between the two groups after the end of the course of treatment compared with P0.05, which indicated that the treatment group was superior to the control group in improving the skin lesions of the patients. The comparison of TCM syndromes score (P0.05) shows that acne mixture has no advantage in improving systemic symptoms. 2. The average oil content before treatment was 163.44 卤42.41 渭 g / cm ~ 2 in the treatment group and 161.08 卤36.74 渭 g / cm ~ 2 in the control group. The results showed that both groups had significant effects in reducing skin fat content. There was significant difference in the content of skin oil between the two groups after the end of the course of treatment, indicating that acne mixture is superior to the control group in improving the content of skin oil. Safety results: 1 case of mild gastrointestinal reaction occurred during treatment in the control group, and the symptoms disappeared after withdrawal. Before and after treatment, the vital signs, liver function and renal function were not abnormal. 4. 4. No recurrence cases were found after 4 weeks follow up. Conclusion: acne mixture has definite curative effect, less adverse reaction and low recurrence rate in the treatment of acne vulgaris.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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