津血源颗粒治疗干燥综合征合并焦虑的临床研究
发布时间：2018-10-30 14:14
【摘要】：目的：使用津血源颗粒联合硫酸羟氯喹(HCQ)片治疗合并焦虑的干燥综合征(SS)患者,评价治疗前后患者干燥症状的改善情况以及焦虑情况的变化。方法：以2015年2月至2016年2月期间至江苏省中医院门诊及病房就诊的40例SS伴焦虑患者为研究对象,随机分为治疗组和对照组,两组各20例,治疗组予津血源颗粒+HCQ片口服治疗,对照组仅以HCQ口服治疗,观察期为8周。使用症状体征量化表评价患者治疗前后病情改变,分析相关实验室检查指标变化情况。并采用医院焦虑量表(HADa)和患者焦虑自评量表(SAS)的问卷调查形式,对所纳入的SS患者治疗前后进行焦虑情况评估,比较患者焦虑症状改善情况。结果：1.治疗前患者一般情况和病情比较：两组患者在年龄、性别和病程分布等一般情况方面无显著性差异。在相关实验室指标、中医症状体征评分和焦虑评分等方面无统计学差异(P0.05)。2.改善患者病情方面：治疗组总体有效率为85%,对照组为55%,两组差异具有统计学意义(P0.05)。两组治疗后实验室指标(包括血沉、C反应蛋白、免疫球蛋白G)方面得到明显改善(P0.05),且津血源治疗组较对照组相比,更能显著降低ESR和CRP水平(P0.05)。在中医症状体征评分方面,两组治疗后均有改善(P0.05)。津血源治疗组患者口干和眼干症状改善具有显著性差异。3.改善患者焦虑方面：HCQ治疗组中患者HADa评分和SAS评分有下降趋势,但无统计学差异(P0.05),但联合津血源治疗可显著降低患者焦虑评分(P0.05)。4.安全性指标方面：在治疗过程中,两组均未发生不良症状,血、尿、粪三大常规和肝肾功能等安全性指标也无明显异常(P0.05)。结论：对SS伴焦虑患者,在使用HCQ治疗原发病的基础上,加用津血源颗粒,能更好地改善其干燥症状及焦虑情绪,在实验室指标方面也有明显改善,且短期内应用未发现不良反应,安全性较好。
[Abstract]:Objective: to evaluate the effect of Jinxueyuan granule combined with hydroxychloroquine sulfate (HCQ) tablets on patients with Sjogren's syndrome (SS) complicated with anxiety and to evaluate the improvement of dry symptoms and the changes of anxiety in patients with Sjogren's syndrome before and after treatment. Methods: from February 2015 to February 2016, 40 SS patients with anxiety were randomly divided into treatment group and control group, 20 cases in each group. The treatment group was treated with Jinxueyuan granule HCQ tablet orally, while the control group was treated with HCQ orally only, the observation period was 8 weeks. The symptoms and signs of the patients before and after treatment were evaluated by quantitative tables, and the changes of related laboratory indicators were analyzed. (HADa) and (SAS) were used to evaluate the anxiety of SS patients before and after treatment to compare the improvement of anxiety symptoms. The result is 1: 1. Comparison of general condition and disease condition before treatment: there was no significant difference in age, sex and course of disease between the two groups. There was no statistical difference in related laboratory indexes, TCM symptom and sign scores and anxiety scores (P0.05). The total effective rate of treatment group was 85 and that of control group was 550.The difference between the two groups was statistically significant (P0.05). The laboratory indexes (including erythrocyte sedimentation rate, C-reactive protein, immunoglobulin G) were significantly improved after treatment in both groups (P0.05), and the levels of ESR and CRP in the blood source treatment group were significantly lower than those in the control group (P0.05). In TCM symptom and sign score, the two groups were improved after treatment (P0.05). There was significant difference in the improvement of dry mouth and dry eye symptoms in the blood source treatment group. Improve the anxiety of patients: in the HCQ treatment group, the HADa score and SAS score decreased, but there was no statistical difference (P0.05), but combined blood therapy significantly decreased the anxiety score (P0.05). Safety indicators: in the treatment process, the two groups did not have adverse symptoms, blood, urine, feces and other three routine safety indicators and liver and kidney function and other safety indicators were not significantly abnormal (P0.05). Conclusion: for SS patients with anxiety, on the basis of using HCQ to treat the primary disease, adding Jinxueyuan granule can improve the dry symptoms and anxiety, and improve the laboratory indexes. No adverse reactions were found in the short-term application, and the safety was good.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7
本文编号：2300230
[Abstract]:Objective: to evaluate the effect of Jinxueyuan granule combined with hydroxychloroquine sulfate (HCQ) tablets on patients with Sjogren's syndrome (SS) complicated with anxiety and to evaluate the improvement of dry symptoms and the changes of anxiety in patients with Sjogren's syndrome before and after treatment. Methods: from February 2015 to February 2016, 40 SS patients with anxiety were randomly divided into treatment group and control group, 20 cases in each group. The treatment group was treated with Jinxueyuan granule HCQ tablet orally, while the control group was treated with HCQ orally only, the observation period was 8 weeks. The symptoms and signs of the patients before and after treatment were evaluated by quantitative tables, and the changes of related laboratory indicators were analyzed. (HADa) and (SAS) were used to evaluate the anxiety of SS patients before and after treatment to compare the improvement of anxiety symptoms. The result is 1: 1. Comparison of general condition and disease condition before treatment: there was no significant difference in age, sex and course of disease between the two groups. There was no statistical difference in related laboratory indexes, TCM symptom and sign scores and anxiety scores (P0.05). The total effective rate of treatment group was 85 and that of control group was 550.The difference between the two groups was statistically significant (P0.05). The laboratory indexes (including erythrocyte sedimentation rate, C-reactive protein, immunoglobulin G) were significantly improved after treatment in both groups (P0.05), and the levels of ESR and CRP in the blood source treatment group were significantly lower than those in the control group (P0.05). In TCM symptom and sign score, the two groups were improved after treatment (P0.05). There was significant difference in the improvement of dry mouth and dry eye symptoms in the blood source treatment group. Improve the anxiety of patients: in the HCQ treatment group, the HADa score and SAS score decreased, but there was no statistical difference (P0.05), but combined blood therapy significantly decreased the anxiety score (P0.05). Safety indicators: in the treatment process, the two groups did not have adverse symptoms, blood, urine, feces and other three routine safety indicators and liver and kidney function and other safety indicators were not significantly abnormal (P0.05). Conclusion: for SS patients with anxiety, on the basis of using HCQ to treat the primary disease, adding Jinxueyuan granule can improve the dry symptoms and anxiety, and improve the laboratory indexes. No adverse reactions were found in the short-term application, and the safety was good.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7
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