冠心静胶囊治疗气虚血瘀型冠心病心绞痛中医症候疗效观察

发布时间：2018-11-03 18:59

【摘要】：目的观察冠心静胶囊治疗气虚血瘀型冠心病心绞痛的中医症候临床疗效,并对其安全性进行评价。方法采用随机、双盲单模拟、阳性药平行对照的研究方法,将448例气虚血瘀型冠心病心绞痛病人随机分为两组。试验组336例(冠心静胶囊,口服,4粒/次,3次/日,早、中、晚服用),对照组112例(参芍胶囊,口服,一次4粒,一日2次,早、晚服用;参芍胶囊模拟剂,口服,一次4粒,一日1次,中午服用)。疗程4周,比较两组中医症候临床疗效,对冠心静胶囊临床应用的安全性进行评价。结果试验组中医证候疗效,中医证候愈显率、总有效率,中医单项症状疗效(主症:胸痛、胸闷,次症:气短、神疲乏力、心悸)均优于对照组,差异具有统计学意义(P0.05);中医单项症状(次症:面色紫暗)与对照组比较无统计学意义(P0.05)。治疗组和对照组在试验期间均未发生不良事件,一般体检指标均未发现异常。结论冠心静胶囊治疗气虚血瘀型冠心病心绞痛中医症候疗效显著,且临床应用安全。
[Abstract]:Objective to observe the clinical effect of Guanxinjing capsule on angina pectoris of coronary heart disease with deficiency of qi and blood stasis, and to evaluate its safety. Methods 448 patients with angina pectoris of qi deficiency and blood stasis type were randomly divided into two groups. 336 cases (Guanxinjing capsule, oral, 4 capsules, 3 times a day, morning, middle, late) in the test group, 112 cases in the control group (Shenshao capsule, 4 capsules once a day, 2 times a day, early and late); Shenshao capsule model, oral, 4 tablets once, once a day, take at noon. After 4 weeks of treatment, the clinical efficacy of Guanxinjing capsule was evaluated. Results the curative effect of TCM syndrome, the effective rate of TCM syndromes, the total effective rate, and the curative effect of single symptom of TCM (main symptom: chest pain, chest tightness, secondary symptom: shortness of breath, fatigue and palpitation) were better than those in the control group. The difference was statistically significant (P0.05). TCM single symptoms (secondary symptoms: purple dark face) and control group had no statistical significance (P0.05). There were no adverse events in the treatment group and the control group, and no abnormality was found in the general physical examination. Conclusion Guanxinjing capsule is effective and safe in treating angina pectoris of coronary heart disease with deficiency of qi and blood stasis.
【作者单位】：河北省邯郸市中心医院;
【分类号】：R259

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