郭连澍教授经验方“丹栀通竹方”治疗中风后抑郁症的临床研究

发布时间：2018-11-03 20:02

【摘要】：目的:观察关“丹栀通竹方”治疗中风后抑郁症的临床。方法:选取2015年3月至2016年2月新乐市中医医院针灸科、康复科门诊、中风病病房收治的60例中风后抑郁患者,按就诊顺序编随机数字表法进行随机分为治疗组和对照组,每组30例。对照组在内科常规治疗基础上,口服盐酸氟西汀(20 mg,1次/d,治疗组在内科常规治疗基础上给予丹栀通竹方加减治疗。治疗前、治疗30 d和治疗60 d采用Fugl-Mayer评估量表(FMA)量表评估患者的偏瘫肢体运动功能;汉密顿抑郁量表(HAMD)量表评分对中风后患者进行抑郁评分评估;运用改良日常生活活动量表(m BI)评分以评估患者的生活质量及采用酶联免疫吸附试验(ELISA)检测脑源性神经营养因子(BDNF)。结果:2组治疗后FMA、m BI评分和BDNF均高于治疗前(P0.05);与对照组比较,治疗组治疗30 d的FMA、m BI评分和BDNF均差异无统计学意义(P0.05),治疗60 d的FMA、m BI评分和BDNF均较高(P0.05)。HAMD评分结果与之相反,BDNF的表达情况与HAMD量表评分呈负相关,Pearson相关系数为-0.949,P=0.0000.05。结论:丹栀通竹方可明显改善PSD抑郁症状,并因此更进一步协助患者躯体功能恢复,而该方发挥疗效可能与上调BDNF有关。
[Abstract]:Objective: to observe the clinical effect of "Dan Zhi Tong Zhu Fang" on post-stroke depression. Methods: from March 2015 to February 2016, 60 patients with post-stroke depression were randomly divided into treatment group and control group. There were 30 cases in each group. The control group was treated with fluoxetine hydrochloride (20 mg,1 / d) on the basis of routine medical treatment, and the treatment group was treated with Danzhi Tongzhu recipe on the basis of routine medical treatment. Before treatment, 30 days after treatment and 60 days after treatment, patients with hemiplegic limb motor function were assessed with (FMA) scale of Fugl-Mayer, and patients with post-stroke depression were evaluated with (HAMD) scale of Hamilton Depression scale. A modified ADL (m BI) score was used to evaluate the quality of life of patients and an enzyme linked immunosorbent assay (ELISA) was used to detect brain-derived neurotrophic factor (BDNF). Results: the FMA,m BI score and BDNF after treatment in both groups were higher than those before treatment (P0.05). Compared with the control group, there was no significant difference in FMA,m BI score and BDNF between the treatment group and the control group (P0.05), but the FMA,m BI score and the BDNF score of the treatment group were higher than those of the control group (P0.05). HAMD score). There was a negative correlation between the expression of BDNF and the score of HAMD, and the Pearson correlation coefficient was -0.949% (0.0000.05). Conclusion: Danzhi Tongzhu decoction can obviously improve the depressive symptoms of PSD and further assist the recovery of somatic function. The effect of Danzhi Tongzhu decoction may be related to the up-regulation of BDNF.
【作者单位】：新乐市中医医院针灸科;
【分类号】：R255.2

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