雷公藤多苷联合白芍总苷与单用雷公藤多苷在干燥综合症治疗疗效

发布时间：2018-11-05 13:40

【摘要】：目的:对比雷公藤多甙联合白芍总甙与单用雷公藤对干燥综合症的疗效。方法:选取2014年9月~2016年3月四川省人民医院风湿免疫科收治的干燥综合症患者60例,按照入院时间编号,偶数患者30例为对照组,该组接受单用雷公藤多甙,奇数患者30例为观察组,该组使用雷公藤多甙联合白芍总甙治疗。对比两组治疗后临床疗效、治疗前后血沉(ESR)、c反应蛋白(CRP)以及血液流变学水平。结果:1治疗后观察组的总有效率为90.00%,明显高于对照组63.33%。治疗后两组患者ESR和CRP水平均比治疗前明显下降,观察组ESR和CRP水平分别为(26.83±0.52mm/h、4.76±0.47mg/L),均比对照组(29.02±0.73mm/h、6.03±0.59mg/L)明显为低。3治疗后观察组全血粘度高切、低切和血浆粘度分别为(4.31±0.39、8.53±0.43、1.43±0.25)m Pa·s,均比对照组(5.01±0.51、9.92±0.55、1.80±0.30)m Pa·s明显为低。结论:单用雷公藤对干燥综合症有明显的治疗效果,在此基础上加用白芍总甙,则疗效更为显著。
[Abstract]:Objective: to compare the efficacy of Tripterygium wilfordii polyglycosides combined with total glucosides of paeony and tripterygium wilfordii on Sjogren syndrome. Methods: from September 2014 to March 2016, 60 patients with Sjogren syndrome were selected from rheumatic immunity department of Sichuan Provincial people's Hospital. According to the admission time number, 30 patients with even number were taken as control group. The group received tripterygium wilfordii polyglycosides alone. Thirty patients with odd number were treated with tripterygium wilfordii and total glucosides of paeony. The clinical effect, (ESR), c reactive protein (CRP) and hemorheology were compared before and after treatment. Results: 1 the total effective rate of the observation group was 90.00g, which was significantly higher than that of the control group (63.33). The levels of ESR and CRP in the observation group were (26.83 卤0.52) mm / h (4.76 卤0.47mg/L), respectively, which were significantly lower than those in the control group (29.02 卤0.73 mm / h). 6.03 卤0.59mg/L was significantly lower. 3 after treatment, the whole blood viscosity, low shear and plasma viscosity in the observation group were (4.31 卤0.39 卤8.53 卤0.43 卤0.25) m Pa s,), respectively. It was significantly lower than that in the control group (5.01 卤0.51g, 9.92 卤0.55U, 1.80 卤0.30) m Pa s). Conclusion: Tripterygium wilfordii is effective in the treatment of Sjogren syndrome.
【作者单位】：四川省医学科学院·四川省人民医院;川北医学院;
【分类号】：R259

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