疏风清热方治疗过敏性紫癜性肾炎风热搏结证的临床研究
发布时间：2018-11-06 10:05
【摘要】：目的:观察疏风清热方对过敏性紫癜性肾炎风热搏结证患者的临床疗效及其安全性,并初步探讨其在治疗过敏性紫癜性肾炎风热搏结证的作用机制。方法:将符合纳入标准的60例过敏性紫癜性肾炎风热搏结证患者,使用抽签法随机分为试验组和对照组,每组各30例。两组患者均给予基础治疗,试验组加用疏风清热方,对照组加用肾炎康复片,疗程为8周。观察并分析两组患者在治疗前与治疗后中医症状计量评分、24小时尿蛋白定量、尿红细胞计数、CD4+、CD8+、CD4+/CD8+、肝功能、肾功能及血压的变化情况。采用SPSS17.0统计软件对数据进行处理,观察疏风清热方对过敏性紫癜性肾炎风热搏结证患者的临床疗效,并初步探讨其作用机制。结果:(1)临床综合疗效:试验组痊愈5例,显效12例,有效9例,无效4例,总有效率为86.67%,对照组痊愈2例,显效6例,有效11例,无效11例,总有效率为63.33%,试验组总有效率高于对照组,有明显差异(P0.05)。(2)中医症候疗效:治疗8周后较治疗前,两组患者的中医症状计量评分均显著下降(P0.01),且试验组比对照组下降更显著(P0.01)。(3)实验室指标:治疗4周后较治疗前,两组患者的24小时尿蛋白定量、尿红细胞计数指标均显著下降(P0.01),但试验组与对照组相比均无明显差别(P0.05);治疗8周后较治疗前,24小时尿蛋白定量、尿红细胞计数、CD4+、CD4+/CD8+指标均显著下降(P0.01),且试验组与对照组相比均下降更明显(P0.05);治疗8周后较治疗前,两组患者的CD8+指标均显著上升(P0.01),且试验组与对照组相比均上升更明显(P0.05)。(4)安全性指标:两组患者治疗前及治疗8周后肝功能及肾功能指标均无显著变化(P0.05),血压稍有下降趋势,但无统计学意义(P0.05)。结论:疏风清热方能显著改善过敏性紫癜性肾炎风热搏结证患者的临床症状,通过纠正机体的免疫功能紊乱,降低患者的24小时尿蛋白定量及尿红细胞计数,是治疗过敏性紫癜性肾炎风热搏结证患者的有效方剂。
[Abstract]:Objective: to observe the clinical efficacy and safety of Shufeng Qingre recipe in the treatment of allergic purpura nephritis with wind-heat beats, and to explore the mechanism of its effect on the treatment of allergic purpura nephritis. Methods: sixty patients with wind-heat syndrome of Henoch-Schonlein purpura nephritis were randomly divided into experimental group and control group with 30 cases in each group. Two groups of patients were given basic treatment, the trial group plus Shufeng Qingre prescription, the control group plus nephritis rehabilitation tablets, the course of treatment was 8 weeks. To observe and analyze the changes of TCM symptom score, urine protein quantity, urine red blood cell count, CD4, CD8, CD4 / CD8, liver function, renal function and blood pressure in both groups before and after treatment. The data were processed by SPSS17.0 software to observe the clinical effect of Shufeng Qingrefang on patients with allergic purpura nephritis and wind-heat syndrome, and to explore its mechanism. Results: (1) Clinical comprehensive efficacy: in the trial group, 5 cases were cured, 12 cases were markedly effective, 9 cases were effective, 4 cases were ineffective, the total effective rate was 86.67 cases. In the control group, 2 cases were cured, 6 cases were markedly effective, 11 cases were ineffective. The total effective rate was 63.33. The total effective rate of the experimental group was higher than that of the control group (P0.05). (2). The scores of TCM symptom in both groups were significantly decreased (P0. 01), and the laboratory index (P0. 01). (3) in the experimental group was significantly lower than that in the control group (P0. 01). (3). Urine red blood cell count index decreased significantly (P0.01), but there was no significant difference between the test group and the control group (P0.05). After 8 weeks of treatment, 24 hours urine protein, urine red blood cell count, CD4, CD4 / CD8 were significantly decreased (P0.01), and compared with the control group, the decrease was more significant (P0.05). After 8 weeks of treatment, the CD8 indexes of both groups were significantly higher than those before treatment (P0.01). Compared with the control group, the safety indexes of the two groups were significantly increased (P0.05). (4): there were no significant changes in liver function and renal function in both groups before treatment and 8 weeks after treatment (P0.05), and the blood pressure decreased slightly. But there was no statistical significance (P0.05). Conclusion: Shufeng Qingre prescription can significantly improve the clinical symptoms of patients with allergic purpura nephritis with wind-heat knotting syndrome. By correcting the disorder of immune function of the body, it can reduce the 24-hour urine protein quantity and urine red blood cell count in patients with Henoch-Schonlein purpura nephritis. Is the treatment of Henoch-Schonlein purpura nephritis wind-heat syndrome patients with an effective prescription.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
本文编号：2313964
[Abstract]:Objective: to observe the clinical efficacy and safety of Shufeng Qingre recipe in the treatment of allergic purpura nephritis with wind-heat beats, and to explore the mechanism of its effect on the treatment of allergic purpura nephritis. Methods: sixty patients with wind-heat syndrome of Henoch-Schonlein purpura nephritis were randomly divided into experimental group and control group with 30 cases in each group. Two groups of patients were given basic treatment, the trial group plus Shufeng Qingre prescription, the control group plus nephritis rehabilitation tablets, the course of treatment was 8 weeks. To observe and analyze the changes of TCM symptom score, urine protein quantity, urine red blood cell count, CD4, CD8, CD4 / CD8, liver function, renal function and blood pressure in both groups before and after treatment. The data were processed by SPSS17.0 software to observe the clinical effect of Shufeng Qingrefang on patients with allergic purpura nephritis and wind-heat syndrome, and to explore its mechanism. Results: (1) Clinical comprehensive efficacy: in the trial group, 5 cases were cured, 12 cases were markedly effective, 9 cases were effective, 4 cases were ineffective, the total effective rate was 86.67 cases. In the control group, 2 cases were cured, 6 cases were markedly effective, 11 cases were ineffective. The total effective rate was 63.33. The total effective rate of the experimental group was higher than that of the control group (P0.05). (2). The scores of TCM symptom in both groups were significantly decreased (P0. 01), and the laboratory index (P0. 01). (3) in the experimental group was significantly lower than that in the control group (P0. 01). (3). Urine red blood cell count index decreased significantly (P0.01), but there was no significant difference between the test group and the control group (P0.05). After 8 weeks of treatment, 24 hours urine protein, urine red blood cell count, CD4, CD4 / CD8 were significantly decreased (P0.01), and compared with the control group, the decrease was more significant (P0.05). After 8 weeks of treatment, the CD8 indexes of both groups were significantly higher than those before treatment (P0.01). Compared with the control group, the safety indexes of the two groups were significantly increased (P0.05). (4): there were no significant changes in liver function and renal function in both groups before treatment and 8 weeks after treatment (P0.05), and the blood pressure decreased slightly. But there was no statistical significance (P0.05). Conclusion: Shufeng Qingre prescription can significantly improve the clinical symptoms of patients with allergic purpura nephritis with wind-heat knotting syndrome. By correcting the disorder of immune function of the body, it can reduce the 24-hour urine protein quantity and urine red blood cell count in patients with Henoch-Schonlein purpura nephritis. Is the treatment of Henoch-Schonlein purpura nephritis wind-heat syndrome patients with an effective prescription.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
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