甘草泻心汤加减治疗溃疡性结肠炎患者57例

发布时间：2018-11-07 10:10

【摘要】：目的探讨甘草泻心汤加减治疗溃疡性结肠炎(UC)的临床疗效及对炎症因子水平的影响。方法选取2013年10月—2016年9月我院114例溃疡性结肠炎患者,根据治疗方案分组,各57例。对照组给予常规西医(柳氮磺吡啶肠溶片)治疗,观察组在此基础上联合甘草泻心汤加减治疗。对比两组治疗前后炎症因子指标肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-17水平,并统计临床疗效及不良反应发生率。结果治疗前,两组TNF-α、IL-6、IL-17水平差异无统计学意义(P0.05);经治疗,观察组各炎症因子指标水平均低于对照组,且治疗总有效率为96.49%,高于对照组的84.21%,差异均有统计学意义(均P0.05);观察组不良反应发生率7.02%与对照组5.26%比较,差异无统计学意义(P0.05)。结论在常规西医治疗基础上,给予UC患者甘草泻心汤加减治疗,临床效果显著,有利于减轻机体炎症反应,具有一定安全性。
[Abstract]:Objective to investigate the clinical effect of Radix Glycyrrhizae Xiexin decoction (QXT) in the treatment of ulcerative colitis (UC) and its effect on inflammatory factors. Methods 114 patients with ulcerative colitis from October 2013 to September 2016 were divided into two groups: 57 cases each. The control group was treated with routine western medicine (sulfasalopyridine enteric-coated tablets), and the observation group was treated with Licorice Xiexin decoction. The levels of tumor necrosis factor 伪 (TNF- 伪), interleukin-6 (IL-6) and IL-17 were compared between the two groups before and after treatment. Results before treatment, there was no significant difference in TNF- 伪 and IL-6,IL-17 levels between the two groups (P0.05). After treatment, the levels of inflammatory factors in the observation group were lower than those in the control group, and the total effective rate was 96.49, which was higher than that in the control group (84.21), and the difference was statistically significant (P0.05). The incidence of adverse reactions was 7.02% in the observation group and 5.26% in the control group. There was no significant difference between the two groups (P0.05). Conclusion on the basis of routine western medicine treatment, the clinical effect of treating UC patients with Gancao Xiexin decoction is remarkable, which is beneficial to alleviate the inflammatory reaction of the body and has certain safety.
【作者单位】：河南省嵩县人民医院中医科;
【分类号】：R259

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