代赭旋覆汤治疗痰气交阻型胃食管反流病的临床研究
发布时间：2018-11-07 16:56
【摘要】：胃食管逆流疾病(Gastroesophageal reflux disease,GERD)其定义是指患者因胃内容物不正常逆流至食管所形成的。其中以心灼热感和胃酸逆流为最常见的症状。虽然西方国家盛行率比东方国家高,但在内地及台湾,胃食管逆流疾病的族群有逐年增加的趋势,不但对病患造成生活的困扰及生活质量的影响,也因此减低工作生产力,消耗诊断及治疗的医疗资源也极为可观。目的：本研究旨在观察台湾地区使用代赭旋覆汤科学中药粉治疗痰气交阻证胃食管反流病的临床疗效,并比较针刺治疗与药物治疗的效果。方法：收集就诊于台湾国烈中医诊所之痰气交阻证胃食管反流病患者60例,全部符合胃食管反流病临床诊断,按照随机分组方法将患者分为观察组和对照组,每组各30例。观察组给予代赭旋覆汤科学中药粉加减,中药粉每日三服,每次一包,每周复诊一次；对照组给予针刺治疗,选穴足三里、中脘、内关、梁门、天枢、四神聪、神庭每周2次,留针30分钟,全部疗程为8周。于治疗前、治疗8周填写量表。统计分析方法：使用SPSS19.0软件对所有数据进行比较分析。采用x2检验分析计数资料,采用t检验分析计量资料,采用秩和检验分析等量资料。结果：于台湾国烈中医诊所共收集60例符合痰气交阻证胃食管反流病患者,分为观察组及对照组,各30例。两组间性别、年龄、病势的差异均不具统计学意义(P0.05),表示观查组与对照组具可比性。观查组与对照组之GerdQ量表、中医症状积分量表积分显示,两组各自之治疗后总积分低于治疗前总积分,其差异具统计学意义。观查组与对照组的治疗后积分,经独立样本t检验分析,P0.05,具统计学意义。分析中医症状积分量表治疗前后之主证与次证积分,观察组67%的症状具统计学意义,对照组78%的症状具统计学意义。结论：GerdQ量表及中医症状积分量表积分均显示,观查组与对照组治疗后症状皆获得改善,且观察组优于对照组。表示代赭旋覆汤科学中药粉治疗胃食管反流病的疗效优于单纯针刺治疗。观察组治疗较具证状针对性,改善各症状效果较突出；对照组具广泛性,普遍减轻各项证状,但单一效用较弱。
[Abstract]:Gastroesophageal reflux disease (Gastroesophageal reflux disease,GERD) is defined as the formation of abnormal reflux of stomach contents to the esophagus. Heartburn and acid reflux are the most common symptoms. Although the prevalence rate in the western countries is higher than that in the eastern countries, in the mainland and Taiwan, the number of people suffering from gastroesophageal reflux disease is increasing year by year, which not only affects the patients' lives and the quality of life, but also reduces the productivity of work. Medical resources for diagnosis and treatment are also very significant. Objective: to observe the clinical effect of treating gastroesophageal reflux disease of syndrome of phlegm and qi obstruction with daizhuanfu decoction in Taiwan, and to compare the effect of acupuncture and drug therapy. Methods: sixty patients with gastroesophageal reflux disease with phlegm and qi obstruction syndrome were collected and divided into observation group (n = 30) and control group (n = 30) according to the clinical diagnosis of gastroesophageal reflux disease (GERD). The observation group was given daizhe Xianfu decoction scientific Chinese medicine powder added or subtracted, three times a day, one packet each time, every week; The control group was treated with acupuncture. Zusanli, Zhongwan, Neiguan, Liang Men, Tianshu, Sishencong, Shenting were treated twice a week with 30 minutes of needle retention for 8 weeks. Before treatment, fill out the scale for 8 weeks. Statistical analysis method: using SPSS19.0 software to compare and analyze all the data. The counting data were analyzed by x2 test, the measurement data were analyzed by t test, and the equivalent data were analyzed by rank sum test. Results: a total of 60 patients with gastroesophageal reflux according to phlegm and qi syndrome were collected in Taiwan Guolie TCM Clinic. They were divided into observation group and control group, 30 cases in each group. There was no significant difference in sex, age and disease potential between the two groups (P0.05), indicating that the observation group was comparable with the control group. The GerdQ scale and TCM symptom scale integral showed that the total score of the two groups after treatment was lower than that before treatment, and the difference was statistically significant. After treatment, the scores of observation group and control group were statistically significant by t test analysis (P 0.05). Before and after treatment, 67% of the symptoms in the observation group were statistically significant, and 78% of the symptoms in the control group were statistically significant. Conclusion: both the GerdQ scale and the integral scale of TCM symptom scale showed that the symptoms of the observation group and the control group were improved after treatment, and the observation group was superior to the control group. The therapeutic effect of traditional Chinese medicine powder in treating gastroesophageal reflux disease is better than that of acupuncture alone. In the observation group, the treatment was more targeted, and the effect of improving the symptoms was more prominent. In the control group, the symptoms were generalized and the symptoms were generally alleviated, but the single effect was weak.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
[Abstract]:Gastroesophageal reflux disease (Gastroesophageal reflux disease,GERD) is defined as the formation of abnormal reflux of stomach contents to the esophagus. Heartburn and acid reflux are the most common symptoms. Although the prevalence rate in the western countries is higher than that in the eastern countries, in the mainland and Taiwan, the number of people suffering from gastroesophageal reflux disease is increasing year by year, which not only affects the patients' lives and the quality of life, but also reduces the productivity of work. Medical resources for diagnosis and treatment are also very significant. Objective: to observe the clinical effect of treating gastroesophageal reflux disease of syndrome of phlegm and qi obstruction with daizhuanfu decoction in Taiwan, and to compare the effect of acupuncture and drug therapy. Methods: sixty patients with gastroesophageal reflux disease with phlegm and qi obstruction syndrome were collected and divided into observation group (n = 30) and control group (n = 30) according to the clinical diagnosis of gastroesophageal reflux disease (GERD). The observation group was given daizhe Xianfu decoction scientific Chinese medicine powder added or subtracted, three times a day, one packet each time, every week; The control group was treated with acupuncture. Zusanli, Zhongwan, Neiguan, Liang Men, Tianshu, Sishencong, Shenting were treated twice a week with 30 minutes of needle retention for 8 weeks. Before treatment, fill out the scale for 8 weeks. Statistical analysis method: using SPSS19.0 software to compare and analyze all the data. The counting data were analyzed by x2 test, the measurement data were analyzed by t test, and the equivalent data were analyzed by rank sum test. Results: a total of 60 patients with gastroesophageal reflux according to phlegm and qi syndrome were collected in Taiwan Guolie TCM Clinic. They were divided into observation group and control group, 30 cases in each group. There was no significant difference in sex, age and disease potential between the two groups (P0.05), indicating that the observation group was comparable with the control group. The GerdQ scale and TCM symptom scale integral showed that the total score of the two groups after treatment was lower than that before treatment, and the difference was statistically significant. After treatment, the scores of observation group and control group were statistically significant by t test analysis (P 0.05). Before and after treatment, 67% of the symptoms in the observation group were statistically significant, and 78% of the symptoms in the control group were statistically significant. Conclusion: both the GerdQ scale and the integral scale of TCM symptom scale showed that the symptoms of the observation group and the control group were improved after treatment, and the observation group was superior to the control group. The therapeutic effect of traditional Chinese medicine powder in treating gastroesophageal reflux disease is better than that of acupuncture alone. In the observation group, the treatment was more targeted, and the effect of improving the symptoms was more prominent. In the control group, the symptoms were generalized and the symptoms were generally alleviated, but the single effect was weak.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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