阿尔茨海默病证候变化与认知结局的关联性
发布时间：2018-11-07 18:37
【摘要】：目的探讨阿尔茨海默病(AD)证候变化与疾病指标认知功能变化的相关性。方法招募阿尔茨海默病患者进行证候横断面调查并进行24周随访研究。年龄40~85岁,分认知正常,轻度认知损害和痴呆3组。认知功能评估使用简易精神状态检查(MMSE)和阿尔茨海默病评价量表-认知部分(ADAS-cog),以临床医生整体印象加照料者补充的痴呆证候变化总体印象量表(CGICS)作为证候评价方法。结果共383位受试者,对73例AD患者进行随访,46例(63%)完成24周随访。证候量表的克朗巴赫系数为0.836,组内相关系数为0.652(P0.001),具有中等重测信度(r=0.561,P=0.004)。肾虚和髓减证随时间变化,其中肾虚证变化与ADAS-cog变化相关(r=0.401,P=0.003)。结论肾虚为代表的证候变化与AD认知结局具有相关性,肾虚证候分数的变化能反映认知功能的变化,在一定程度上可作为AD结局指标。
[Abstract]:Objective to investigate the correlation between the changes of (AD) syndrome and cognitive function of Alzheimer's disease. Methods patients with Alzheimer's disease were recruited for cross-sectional investigation and 24-week follow-up study. The patients aged 40 to 85 years were divided into 3 groups: normal cognition, mild cognitive impairment and dementia. Cognitive function assessment was performed with simple mental state examination (MMSE) and Alzheimer's disease assessment scale (ADAS-cog). General impression scale (CGICS) was used to evaluate the symptoms of dementia. Results A total of 383 subjects were followed up in 73 patients with AD. 46 patients (63%) were followed up for 24 weeks. The Cronbach coefficient of syndrome scale was 0.836, the intra-group correlation coefficient was 0.652 (P0. 001), and had a moderate retest reliability (r = 0. 561, P = 0. 004). The changes of kidney deficiency and medullary depression were correlated with the changes of ADAS-cog (r = 0.401, P < 0. 003). Conclusion the changes of syndromes represented by kidney deficiency are correlated with the cognitive outcome of AD. The change of the score of syndrome of kidney deficiency can reflect the changes of cognitive function and can be used as the outcome index of AD to some extent.
【作者单位】： 北京中医药大学东直门医院脑病三科;北京中医药大学循证医学中心;中国中医科学院中医临床基础医学研究所;
【基金】：国家自然科学基金资助项目(No.81473518、No.81573824、No.81503625) 高等学校学科创新引智计划(No.B08006) 首都卫生发展专项(No.2014-1-4191)
【分类号】：R277.7
[Abstract]:Objective to investigate the correlation between the changes of (AD) syndrome and cognitive function of Alzheimer's disease. Methods patients with Alzheimer's disease were recruited for cross-sectional investigation and 24-week follow-up study. The patients aged 40 to 85 years were divided into 3 groups: normal cognition, mild cognitive impairment and dementia. Cognitive function assessment was performed with simple mental state examination (MMSE) and Alzheimer's disease assessment scale (ADAS-cog). General impression scale (CGICS) was used to evaluate the symptoms of dementia. Results A total of 383 subjects were followed up in 73 patients with AD. 46 patients (63%) were followed up for 24 weeks. The Cronbach coefficient of syndrome scale was 0.836, the intra-group correlation coefficient was 0.652 (P0. 001), and had a moderate retest reliability (r = 0. 561, P = 0. 004). The changes of kidney deficiency and medullary depression were correlated with the changes of ADAS-cog (r = 0.401, P < 0. 003). Conclusion the changes of syndromes represented by kidney deficiency are correlated with the cognitive outcome of AD. The change of the score of syndrome of kidney deficiency can reflect the changes of cognitive function and can be used as the outcome index of AD to some extent.
【作者单位】： 北京中医药大学东直门医院脑病三科;北京中医药大学循证医学中心;中国中医科学院中医临床基础医学研究所;
【基金】：国家自然科学基金资助项目(No.81473518、No.81573824、No.81503625) 高等学校学科创新引智计划(No.B08006) 首都卫生发展专项(No.2014-1-4191)
【分类号】：R277.7
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