冬病夏治治疗膝骨关节炎阳虚寒凝证的临床疗效观察
发布时间：2018-11-08 20:56
【摘要】：目的:观察冬病夏治治疗膝骨关节炎阳虚寒凝证的临床疗效,为临床治疗膝骨关节炎提供另外一种思路与方法。方法:选择湖南中医药大学第一附属医院骨伤科门诊在2015年1月至2015年7月期间就诊的患者,符合膝骨关节炎诊断,中医辨证为阳虚寒凝证,累积80例。按随机数字表法将80例患者膝骨关节炎(阳虚寒凝证)患者随机分为两组,对照组40例患者口服硫酸氨基葡萄糖胶囊(每日3次,每次2粒),口服双醋瑞因胶囊(4周前,每日1粒,晚餐后口服,后每日2次,每次1粒,饭后口服),治疗组口服硫酸氨基葡萄糖胶囊(每日3次,每次2粒),口服双醋瑞因胶囊(4周前,每日1粒,晚餐后口服,后每日2次,每次1粒,饭后口服)配合三伏天穴位贴敷治疗;两组口服药物的治疗时间均为3个月。治疗结束后,观察两组患者治疗前与治疗后、冬天三九天的VAS评分、WOMAC评分及中医疗效评价。结果:1.组内比较:治疗后,对照组与治疗组两组患者的VAS评分、WOMAC评分较治疗前得分均有降低,两组患者与治疗前比较均有差异,差异有显著和非常显著的统计学意义((P0.05,P0.01);一九天对照组与治疗组两组患者的VAS评分、WOMAC评分得分较治疗前得分有降低,与治疗前比较,两者得分有显著统计学意义(P0.05);二九天与三九天对照组VAS评分、WOMAC评分得分较治疗前得分有所降低,但与治疗前比较无差异,无统计学意义(P0.05),治疗组VAS评分、WOMAC评分得分较治疗前得分有降低,与治疗前比较,两者得分均有统计学意义(P0.05);2.组间比较:治疗后及一九天两个时间段,对照组与治疗组在VAS评分、WOMAC评分及中医疗效方面比较,无统计学意义(P0.05);在二九天、三九天两个时间段,对照组与治疗组在VAS评分、WOMAC评分及中医疗效方面比较有显著统计学意义(P0.05)和非常显著的统计学意义(P0.01)。结论:1.冬病夏治法较单纯口服药物治疗更能改善膝骨关节炎阳虚寒凝证在三九天的疼痛情况。2.冬病夏治法较单纯口服药物治疗能明显降低膝骨关节炎阳虚寒凝证在三九天的WOMAC评分。3.冬病夏治法较单纯口服药物治疗能明显减少膝骨关节炎阳虚寒凝证在三九天的发病次数。4.冬病夏治法较单纯口服药物治疗能明显减少膝骨关节炎阳虚寒凝证在三九天的畏寒、遇寒痛增情况。
[Abstract]:Objective: to observe the clinical effect of treating knee osteoarthritis with yang deficiency and cold coagulation in the treatment of winter disease and summer, and to provide another way of thinking and method for clinical treatment of knee osteoarthritis. Methods: the patients in Department of Orthopaedics and Trauma of the first affiliated Hospital of Hunan University of traditional Chinese Medicine from January 2015 to July 2015 were selected and diagnosed according to the diagnosis of knee osteoarthritis. 80 patients with knee osteoarthritis (Yang deficiency and cold coagulation syndrome) were randomly divided into two groups: the control group (40 cases) received glucosamine sulfate capsules (2 capsules per day 3 times a day) and diacetate capsules (4 weeks ago). The treatment group was treated with glucosamine sulfate capsules (2 capsules per day, 3 times a day) and diacetate capsules (1 capsule per day, 4 weeks ago). After dinner oral, after 2 times a day, each time, oral after meals) with three days of acupoint application treatment; The treatment time of oral drugs in both groups was 3 months. After treatment, the VAS score, WOMAC score and TCM curative effect were observed before and after treatment. The result is 1: 1. Intra-group comparison: after treatment, the VAS scores and WOMAC scores of patients in the control group and the treatment group were lower than those before treatment, and there were significant and very significant differences between the two groups (P 0.05, P 0.05). P0.01); The VAS score and WOMAC score of the control group and the treatment group were significantly lower than those before treatment (P0.05). The scores of VAS and WOMAC in the control group were lower than those before treatment, but there was no significant difference between before and after treatment (P0.05). The VAS score and WOMAC score of the treatment group were lower than those before treatment. Compared with before treatment, both scores were statistically significant (P0.05); 2. Comparison between groups: after treatment and 19 days, the control group and the treatment group in VAS score, WOMAC score and TCM efficacy comparison, there was no statistical significance (P0.05); In two periods of 29 days, 39 days, the control group and the treatment group in VAS score, WOMAC score and curative effect of traditional Chinese medicine compared with significant statistical significance (P0.05) and very significant statistical significance (P0.01). Conclusion: 1. The treatment of winter disease and summer can improve the pain of knee osteoarthritis with yang deficiency and cold coagulation in 39 days. 2. The treatment of winter disease and summer can obviously reduce the WOMAC score of knee osteoarthritis with yang deficiency and cold coagulation in 39 days. The treatment of winter disease and summer treatment can obviously reduce the incidence times of yang deficiency and cold coagulation syndrome of knee osteoarthritis in 39 days. 4. The treatment of winter disease and summer treatment was more effective than oral medicine only in reducing the chills and increasing cold pain in knee osteoarthritis with Yang deficiency and cold coagulation syndrome in three or nine days.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9
[Abstract]:Objective: to observe the clinical effect of treating knee osteoarthritis with yang deficiency and cold coagulation in the treatment of winter disease and summer, and to provide another way of thinking and method for clinical treatment of knee osteoarthritis. Methods: the patients in Department of Orthopaedics and Trauma of the first affiliated Hospital of Hunan University of traditional Chinese Medicine from January 2015 to July 2015 were selected and diagnosed according to the diagnosis of knee osteoarthritis. 80 patients with knee osteoarthritis (Yang deficiency and cold coagulation syndrome) were randomly divided into two groups: the control group (40 cases) received glucosamine sulfate capsules (2 capsules per day 3 times a day) and diacetate capsules (4 weeks ago). The treatment group was treated with glucosamine sulfate capsules (2 capsules per day, 3 times a day) and diacetate capsules (1 capsule per day, 4 weeks ago). After dinner oral, after 2 times a day, each time, oral after meals) with three days of acupoint application treatment; The treatment time of oral drugs in both groups was 3 months. After treatment, the VAS score, WOMAC score and TCM curative effect were observed before and after treatment. The result is 1: 1. Intra-group comparison: after treatment, the VAS scores and WOMAC scores of patients in the control group and the treatment group were lower than those before treatment, and there were significant and very significant differences between the two groups (P 0.05, P 0.05). P0.01); The VAS score and WOMAC score of the control group and the treatment group were significantly lower than those before treatment (P0.05). The scores of VAS and WOMAC in the control group were lower than those before treatment, but there was no significant difference between before and after treatment (P0.05). The VAS score and WOMAC score of the treatment group were lower than those before treatment. Compared with before treatment, both scores were statistically significant (P0.05); 2. Comparison between groups: after treatment and 19 days, the control group and the treatment group in VAS score, WOMAC score and TCM efficacy comparison, there was no statistical significance (P0.05); In two periods of 29 days, 39 days, the control group and the treatment group in VAS score, WOMAC score and curative effect of traditional Chinese medicine compared with significant statistical significance (P0.05) and very significant statistical significance (P0.01). Conclusion: 1. The treatment of winter disease and summer can improve the pain of knee osteoarthritis with yang deficiency and cold coagulation in 39 days. 2. The treatment of winter disease and summer can obviously reduce the WOMAC score of knee osteoarthritis with yang deficiency and cold coagulation in 39 days. The treatment of winter disease and summer treatment can obviously reduce the incidence times of yang deficiency and cold coagulation syndrome of knee osteoarthritis in 39 days. 4. The treatment of winter disease and summer treatment was more effective than oral medicine only in reducing the chills and increasing cold pain in knee osteoarthritis with Yang deficiency and cold coagulation syndrome in three or nine days.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9
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