参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响
发布时间：2018-11-10 12:00
【摘要】：目的:探讨参附养荣汤加味治疗病毒性心肌炎(VMC)慢性期的疗效及对患者血清中白细胞介素(IL)-17,IL-27,IL-6,IL-9和核转录因子(NF)-κB水平的影响。方法:将140例VMC患者随机按数字表法分为对照组和观察组各70例。对照组给予西医综合干预措施。观察组在对照组治疗的基础上给予参附养荣汤加味,1剂/d,早晚2次内服;两组患者连续治疗8周。比较两组患者阴阳两虚证症状评分、血清中心型游离脂肪酸结合蛋白(H-FABP)和肌钙蛋白I(c Tn I)水平、总体疗效及不良反应发生。检测两组患者血清中IL-17,IL-27,IL-6,IL-9和NF-κB水平。结果:治疗后观察组阴阳两虚证症状(心悸、气短、肢冷畏寒、烦躁、喘促、汗多、浮肿)评分、血清中H-FABP和c Tn I水平均明显低于对照组(P0.01);观察组的临床总有效率为91.18%,明显高于对照组76.12%(P0.05);观察组患者的头痛等不良反应发生率均少于对照组,其中恶心呕吐和腹泻明显少于对照组(P0.05);观察组治疗后血清中IL-17,IL-6,IL-9和NF-κB水平均明显低于对照组,IL-27高于对照组(P0.01)。结论:在西医常规治疗的基础上,参附养荣汤加味对VMC慢性期患者发挥了良好疗效,且安全性好,调节血清IL-17,IL-27,IL-6,IL-9和NF-κB水平变化可能是其作用机制之一。
[Abstract]:Objective: to investigate the therapeutic effect of Shenfu Yangrong decoction on chronic phase of viral myocarditis (VMC) and its effect on the levels of interleukin-17 (IL) -27 (IL-27) IL-6 (IL-6) IL-9 and nuclear transcription factor (NF)-魏 B in serum of patients with viral myocarditis. Methods: 140 patients with VMC were randomly divided into control group (n = 70) and observation group (n = 70). The control group was given western comprehensive intervention. The observation group was treated with Shenfu Yangrong decoction on the basis of the treatment in the control group, 1 dose per day, 2 times in the morning and evening, and the patients in the two groups were treated continuously for 8 weeks. The scores of symptoms of yin and yang deficiency syndrome, the levels of serum free fatty acid binding protein (H-FABP) and troponin I (c Tn I), the overall curative effect and the occurrence of adverse reactions were compared between the two groups. The serum levels of IL-17,IL-27,IL-6,IL-9 and NF- 魏 B were measured in both groups. Results: after treatment, the symptoms of Yin and Yang deficiency syndrome (palpitation, shortness of breath, cold and cold limbs, irritability, shortness of breath, sweating and swelling) in the observation group were significantly lower than those in the control group (P0.01). The serum levels of H-FABP and c Tn I in the observation group were significantly lower than those in the control group (P0.01). The total effective rate of the observation group was 91.18%, which was significantly higher than that of the control group (76.12%) (P0.05). The incidence of headache and other adverse reactions in the observation group was lower than that in the control group, and the incidence of nausea, vomiting and diarrhea was significantly lower than that in the control group (P0.05). The serum levels of IL-17,IL-6,IL-9 and NF- 魏 B in the observation group were significantly lower than those in the control group, and the levels of IL-27 were higher than those in the control group (P0.01). Conclusion: on the basis of routine western medicine treatment, Shenfu Yangrong decoction has a good curative effect on chronic VMC patients, and is safe and adjusts serum IL-17,IL-27,IL-6,. The changes of IL-9 and NF- 魏 B levels may be one of its mechanisms.
【作者单位】： 郑州大学附属郑州中心医院;
【基金】：河南省科技厅科技攻关项目(2015zw057)
【分类号】：R259
本文编号：2322417
[Abstract]:Objective: to investigate the therapeutic effect of Shenfu Yangrong decoction on chronic phase of viral myocarditis (VMC) and its effect on the levels of interleukin-17 (IL) -27 (IL-27) IL-6 (IL-6) IL-9 and nuclear transcription factor (NF)-魏 B in serum of patients with viral myocarditis. Methods: 140 patients with VMC were randomly divided into control group (n = 70) and observation group (n = 70). The control group was given western comprehensive intervention. The observation group was treated with Shenfu Yangrong decoction on the basis of the treatment in the control group, 1 dose per day, 2 times in the morning and evening, and the patients in the two groups were treated continuously for 8 weeks. The scores of symptoms of yin and yang deficiency syndrome, the levels of serum free fatty acid binding protein (H-FABP) and troponin I (c Tn I), the overall curative effect and the occurrence of adverse reactions were compared between the two groups. The serum levels of IL-17,IL-27,IL-6,IL-9 and NF- 魏 B were measured in both groups. Results: after treatment, the symptoms of Yin and Yang deficiency syndrome (palpitation, shortness of breath, cold and cold limbs, irritability, shortness of breath, sweating and swelling) in the observation group were significantly lower than those in the control group (P0.01). The serum levels of H-FABP and c Tn I in the observation group were significantly lower than those in the control group (P0.01). The total effective rate of the observation group was 91.18%, which was significantly higher than that of the control group (76.12%) (P0.05). The incidence of headache and other adverse reactions in the observation group was lower than that in the control group, and the incidence of nausea, vomiting and diarrhea was significantly lower than that in the control group (P0.05). The serum levels of IL-17,IL-6,IL-9 and NF- 魏 B in the observation group were significantly lower than those in the control group, and the levels of IL-27 were higher than those in the control group (P0.01). Conclusion: on the basis of routine western medicine treatment, Shenfu Yangrong decoction has a good curative effect on chronic VMC patients, and is safe and adjusts serum IL-17,IL-27,IL-6,. The changes of IL-9 and NF- 魏 B levels may be one of its mechanisms.
【作者单位】： 郑州大学附属郑州中心医院;
【基金】：河南省科技厅科技攻关项目(2015zw057)
【分类号】：R259
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1 张传儒;参附养荣汤治疗多汗症31例[J];南京中医药大学学报;1995年02期
，本文编号：2322417
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