自拟平肝养血汤治疗偏头痛肝阳上亢证的临床观察

发布时间：2018-11-11 15:26

【摘要】：研究目的:本研究课题是基于通过对近些年来偏头痛肝阳上亢证的中医辨证论治观察及偏头痛肝阳上亢证的治疗进行调查、分析、思考后,针对当今中西医治疗上的成果及出现的问题进行分析思考与总结。最终拟定平肝养血汤,对临床上出现的偏头痛肝阳上亢证患者的证候指征评分作为观察与统计的指标、以中医辨证论治为方法的观察与研究,探讨并初步制定一套更为规范化的临床治疗方案,观察中药治疗偏头痛肝阳上亢证的疗效,从而探讨新的治疗偏头痛肝阳上亢证的规范化中医诊疗方案。研究方法:选取72例在长春中医药大学附属医院老年病一科门诊或疗区就诊的符合本研究纳入标准的偏头痛患者,随机分为治疗组36例,对照组36例,病例采集日期为2013年12月至2015年12月。治疗组给予闫凤杰教授的经验方平肝养血汤;对照组给予天士力制药集团股份有限公司养血清脑颗粒(国药准字Z10960082)口服。两组疗程相同,均为4周。分别观察两组患者的疼痛评分变化和中医证侯积分、病程、年龄等进行统计分析。分别观察治疗期间的药物疗效性和安全性。研究结果:(1)治疗组与对照组临床疗效的总有效率分别为88.89%和66.67%。治疗组与对照组的总疗效有明显差异(P0.05),说明治疗组平肝养血汤的疗效优于对照组养血清脑颗粒。(2)两组患者治疗后的中医证侯总积分对比治疗前均有明显下降,同时两组患者治疗后的组间比较有明显差异(P0.05),说明平肝养血汤和养血清脑颗粒两种药物均能有效缓解头痛,改善中医症候,同时治疗组平肝养血汤在缓解头痛以及改善中医症候方面均优于养血清脑颗粒。结论:在临床上两种药物取均有较好疗效,经过研究结果分析后发现治疗组在临床症状的改善等方面要优于对照组,服药过程中患者安全性指标均未见异常,说明平肝养血汤有确切疗效又安全可靠,具有一定的临床推广价值。
[Abstract]:Objective: this research subject is based on the observation of TCM syndrome differentiation and treatment of migraine liver yang hyperactivity syndrome in recent years and the treatment of migraine liver yang hyperactivity syndrome. This paper analyzes and summarizes the achievements and problems in the treatment of traditional Chinese and western medicine. Finally, we draw up Pinggan Yangxue decoction, and observe and study the syndrome indication score of the patients with syndrome of migraine and liver yang hyperactivity in clinic as the index of observation and statistics, and take TCM syndrome differentiation and treatment as the method of observation and research. To explore and preliminarily establish a more standardized clinical treatment plan, observe the efficacy of Chinese medicine in treating migraine and liver yang hyperactivity syndrome, and explore a new standardized Chinese medicine diagnosis and treatment scheme for migraine liver yang hyperactivity syndrome. Methods: a total of 72 patients with migraine, who met the criteria of this study, were randomly divided into treatment group (n = 36) and control group (n = 36). Cases were collected from December 2013 to December 2015. The treatment group was given Professor Yan Fengjie's experience Fang Pinggan Yangxue decoction and the control group was given Yangxuannao granule (Z10960082) of Tianshili Pharmaceutical Group Co., Ltd. The course of treatment was the same in both groups (4 weeks). The changes of pain score, TCM syndromes score, course of disease, age and so on were observed. The efficacy and safety of the drug during the treatment were observed. Results: (1) the total effective rates of the treatment group and the control group were 88.89% and 66.67% respectively. There was significant difference between the treatment group and the control group in the total curative effect (P0.05), indicating that the therapeutic effect of the treatment group was better than that of the control group. (2) after treatment, the total score of traditional Chinese medicine syndrome in the two groups were significantly decreased before treatment. At the same time, there was a significant difference between the two groups after treatment (P0.05), indicating that Pinggan Yangxue decoction and Yangxuannao granule can effectively relieve headache and improve TCM symptoms. At the same time, the treatment group was superior to Yangxuannao granule in relieving headache and improving symptoms of TCM. Conclusion: the two drugs have good curative effect in clinic. After the analysis of the results, it is found that the treatment group is superior to the control group in the improvement of clinical symptoms, and the safety indexes of the patients in the course of taking medicine are not abnormal. It shows that Pinggan Yangxue decoction has definite curative effect, safe and reliable, and has certain clinical popularizing value.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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