通窍活血汤对外伤后水瘀互结型脑积水患者血清神经生化标志物及脑脊液p73,p38蛋白表达的影响

发布时间：2018-11-11 16:36

【摘要】：目的:探讨通窍活血汤对外伤后水瘀互结型脑积水患者血清神经生化标志物及脑脊液p73,p38表达和认知功能的影响。方法:选取新乡医学院第一附属医院就诊并诊断为外伤后脑积水患者74例,按照随机数字表法分为两组,对照组(37例)给予常规对症及支持治疗,观察组(37例)在对照组基础上予通窍活血汤治疗,观察并记录两组患者治疗前后人脑髓鞘碱性蛋白(myelin basic protein,MBP),中枢神经特异蛋白(Protein S100β),神经元特异性烯醇化酶(neuron-specificenolase,NSE)水平,脑脊液p73,p38水平,术前简易精神状态评价量表(minimum mental state examination,MMSE),格拉斯哥昏迷评分(Glasgow coma scale,GCS),同时对比临床疗效及不良反应发生情况。结果:对照组治疗有效率低于观察组(P0.05);与治疗前比较,两组治疗后血清MBP,S100β,NSE水平均较治疗前明显降低(P0.05),且观察组显著低于对照组(P0.05);两组治疗后患者的脑脊液p73,p38蛋白表达均升高(P0.05),且观察组高于对照组(P0.05);两组治疗后患者的MMSE,GCS评分均升高(P0.05),且观察组高于对照组(P0.05)。结论:通窍活血汤能有效改善患者临床症状,可能与其降低外伤后水瘀互结型脑积水患者血清MBP,S-100β,NSE水平,提高脑脊液p73,p38蛋白表达水平有关。
[Abstract]:Objective: to investigate the effect of Tongqiao Huoxue decoction on serum neurobiochemical markers, expression of p73 p38 and cognitive function in patients with hydrocephalus. Methods: a total of 74 patients with post-traumatic hydrocephalus were selected from the first affiliated Hospital of Xinxiang Medical College and were randomly divided into two groups: the control group (37 cases) received routine treatment and supportive therapy. The observation group (37 cases) was treated with Tongqiao Huoxue decoction on the basis of the control group. The myelin basic protein (myelin basic protein,MBP) and central nervous specific protein (Protein S100 尾) were observed and recorded before and after treatment in both groups. The levels of neuron-specific enolase (neuron-specificenolase,NSE), cerebrospinal fluid (CSF) p73 and p38, preoperative mini-mental state assessment scale (minimum mental state examination,MMSE), Glasgow coma score (Glasgow coma scale,GCS), etc. At the same time, the clinical efficacy and adverse reactions were compared. Results: the effective rate of treatment in the control group was lower than that in the observation group (P0.05), the levels of serum MBP,S100 尾 and NSE in the two groups were significantly lower than those before treatment (P0.05), and the levels of serum MBP,S100 尾 and NSE in the observation group were significantly lower than those in the control group (P0.05). After treatment, the expression of p73 p38 protein in cerebrospinal fluid increased in both groups (P0.05), and was higher in observation group than that in control group (P0.05). The MMSE,GCS scores of the two groups were increased after treatment (P0.05), and the observation group was higher than the control group (P0.05). Conclusion: Tongqiao Huoxue decoction can effectively improve the clinical symptoms of patients with hydrocephalus, which may be related to the decrease of serum MBP,S-100 尾 and NSE levels in patients with hydrocephalus and increase the expression level of p73 p38 protein in cerebrospinal fluid.
【作者单位】：新乡医学院第一附属医院;
【基金】：河南省卫生厅科技攻关项目(201303105)
【分类号】：R269

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