从“肝”论治寻常型银屑病的临床疗效研究

发布时间：2018-11-13 16:54

【摘要】：目的:总结导师张晓杰教授从“肝”论治寻常型银屑病的临床经验,观察导师经验方治疗寻常型银屑病的的临床疗效,探索中医辨证治疗寻常型银屑病新的思路和方法。方法:收集山东省中医院皮肤科门诊80例寻常型银屑病患者,将其辨证分型,分为肝经血热型、肝经湿热型、肝经瘀热型、肝虚血燥型,分别给予清肝凉血汤、加味龙胆泻肝汤、郁金消银汤、润燥消银汤治疗,外用凡士林软膏和龙珠软膏,2周为1疗程,观察8周。在观察开始时和结束时填写临床观察表和情绪自评量表,根据治疗前后患者皮损PASI评分分析疗效,通过情绪自评量表分析寻常型银屑病与情绪因素的相关性,通过记录患者的不良反应来监测药物副作用。结果:所有患者治疗后,总愈显率为72.5%,总有效率为97.5%。所有患者治疗前PASI评分均值为(17.82±5.23),治疗后PASI评分均值为(5.66±6.26),治疗前后PASI评分比较,差异具有统计学意义(P㩳0.01)。所有患者治疗前SAS标准分均值为(53.28±10.39),SDS标准分均值为(56.61±11.77);治疗后SAS标准分均值为(42.34±11.77),SDS标准分均值为(42.35±13.53),治疗后较治疗前分值降低(P㩳0.01),差异具有统计学意义。结论:导师从“肝”辨证分型论治寻常型银屑病临床疗效确切,导师经验方治疗寻常型银屑病有效率较高、副作用较少。焦虑、抑郁等情绪因素对寻常型银屑病的发生发展有一定作用,导师经验方可降低部分银屑病患者的焦虑、抑郁评分。
[Abstract]:Objective: to summarize the clinical experience of professor Zhang Xiaojie in treating psoriasis vulgaris from the viewpoint of "liver", observe the clinical effect of the prescription for treating psoriasis vulgaris, and explore the new thinking and method of treating psoriasis vulgaris based on TCM syndrome differentiation. Methods: 80 patients with psoriasis vulgaris in dermatology department of Shandong traditional Chinese Medicine Hospital were divided into three types: liver meridian blood heat type, liver meridian damp-heat type, liver meridian stasis heat type, liver deficiency and blood dryness type, respectively. Modified Longdan Xiegan decoction, Yujin Xiaoyin decoction, Runzao Xiaoyin decoction treatment, external use of vaseline ointment and Longzhu ointment, 2 weeks as a course of treatment, observe 8 weeks. At the beginning and the end of the observation, the clinical observation form and the emotional self-rating scale were filled out. According to the PASI score of skin lesions of the patients before and after treatment, the correlation between psoriasis vulgaris and emotional factors was analyzed by self-rating emotional scale. Adverse drug side effects were monitored by recording adverse reactions in patients. Results: after treatment, the total recovery rate was 72.5% and the total effective rate was 97.5%. The mean PASI score before and after treatment was (17.82 卤5.23) and (5.66 卤6.26) respectively. The difference of PASI score before and after treatment was statistically significant (P0.01). The mean SAS standard score before treatment was (53.28 卤10.39), SDS (56.61 卤11.77). The mean standard score of SAS was (42.34 卤11.77), SDS) after treatment (42.35 卤13.53), which was significantly lower than that before treatment (P0. 01). Conclusion: according to the syndrome differentiation and classification of "liver", the tutor is effective in treating psoriasis vulgaris, and the effective rate is higher and the side effect is less. Anxiety, depression and other emotional factors have a certain effect on the occurrence and development of psoriasis vulgaris. Mentors can reduce the anxiety and depression scores of some psoriasis patients.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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