从水液代谢理论论治干燥综合征气阴两虚型的理论探讨及临床研究

发布时间：2018-11-15 18:07

【摘要】：目的:本课题通过研究水液代谢理论,观察水液代谢和原发性干燥综合征之间的关系,探讨本病的病名、病因病机及治疗方法,为临床治疗气阴两虚型干燥综合征提供思路和方法。方法:主要通过两个部分进行论述,第一部分,通过检索国内外文献,对干燥综合征的病名、病因病机进行探讨,基于水液代谢理论拟定生津润燥方;第二部分,研究50例符合气阴两虚型干燥综合征患者,随机分为两组,每组25例,其中治疗组为中药生津润燥方联合硫酸羟氯喹片、白芍总苷胶囊治疗,对照组为硫酸羟氯喹片和白芍总苷胶囊治疗,疗程为12周,分别记录患者治疗前与治疗后的ESSDAI评分、中医证候积分、实验室指标变化等,结合治疗数据进行疗效评价。结果:通过对研究数据的总结,治疗组总有效率为72%,对照组总有效率为60%,并且治疗组对中医诸症均有显著改善,对眼干、口干、纳呆、手足心热、乏力、关节痛的改善,治疗前后有明显差异(P0.05),而对皮肤干、大便干、关节肿胀的改善,两组比较治疗前后无明显差异(P0.05);两组ESR、IgG、RF均有明显改善,有统计学意义(P0.05);治疗组仅发现一例SSB改善,而两组ANA定量、SSA变化皆不明显。结论:本次临床研究证实,通过对水液代谢理论的研究,在此基础上自拟方剂生津润燥方,采用清燥生津、益气养阴之法,可有效改善患者眼干、口干症状,同时改善其气阴两虚的相关症状,降低炎性指标,改善的生活质量,研究结果提示生津润燥方有抗炎和调节免疫的作用,具有一定的临床意义。
[Abstract]:Objective: to investigate the relationship between water and liquid metabolism and primary Sjogren's syndrome by studying the theory of water and liquid metabolism, and to explore the name, etiology, pathogenesis and treatment of the disease. To provide ideas and methods for clinical treatment of Sjogren syndrome with deficiency of Qi and Yin. Methods: mainly through two parts to discuss, the first part, through the retrieval domestic and foreign literature, carries on the discussion to the Sjogren syndrome disease name, the etiology and the pathogenesis, based on the water liquid metabolism theory formulates the Shengjin Runzao recipe; In the second part, 50 cases of Sjogren syndrome with deficiency of qi and yin were randomly divided into two groups, 25 cases in each group. The treatment group was treated with Shengjin Runzao prescription combined with hydroxychloroquine sulfate tablet and total paeony glucoside capsule. The control group was treated with hydroxychloroquine sulfate and total glucoside of paeony for 12 weeks. The ESSDAI scores, TCM syndromes and laboratory indexes were recorded before and after treatment, respectively. Results: the total effective rate of the treatment group was 72.The total effective rate of the control group was 60, and the treatment group had significant improvement on the symptoms of traditional Chinese medicine, including dry eyes, dry mouth, dry eyes, hot palms and feet, and fatigue. The improvement of arthralgia was significantly different before and after treatment (P0.05), but there was no significant difference between the two groups before and after treatment (P0.05). There was significant improvement in ESR,IgG,RF in both groups (P0.05); in the treatment group, only one case of SSB was improved, while the changes of ANA quantitative and SSA were not obvious in both groups. Conclusion: this clinical study confirmed that through the study of the theory of water and liquid metabolism, the prescription of Shengjin Runzao, a self-made prescription, can effectively improve the symptoms of dry eyes and dry mouth by using the method of clearing dryness and nourishing qi and nourishing yin. At the same time, it can improve the symptoms of deficiency of Qi and Yin, reduce the inflammatory index, improve the quality of life. The research results suggest that Shengjin Runzao prescription has the function of anti-inflammation and regulating immunity, which has certain clinical significance.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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