肾炎消白颗粒治疗慢性肾小球肾炎蛋白尿的临床观察
发布时间：2018-11-24 10:27
【摘要】：目的观察肾炎消白颗粒治疗原发性肾小球肾炎蛋白尿的临床疗效,为临床治疗肾小球肾炎蛋白尿提供可行有效的方法,为临床用药提供良好的依据。方法选黑龙江省中医医院肾病科门诊2014年5月~2015年12月满足条件的慢性肾小球肾炎患者90例,随机分成治疗组与对照组,每组各45例,治疗组在给予常规治疗基础上加用肾炎消白颗粒,对照组在常规治疗基础上服用肾炎康复片,每4周为1个疗程,观察3个疗程,分别在治疗前后检测相关指标,并分析指标的变化及意义。结果在整个试验的各时间点时,治疗组与对照组各项指标(24小时尿蛋白定量、中医症候积分、尿微量白蛋白/尿肌酐、尿足细胞含量)均变化明显,有统计学意义(p0.01)。试验4周与12周时,治疗组与对照组患者两组疗效相当,无统计学意义(p0.05);8周时各指标亦均下降,其中治疗组24小时尿蛋白定量有效率、尿微量白蛋白/尿肌酐有效率较对照组变化明显,有统计学意义(p0.05);12周时,治疗组24小时尿蛋白定量较对照组下降明显,有统计学意义(p0.05);未出现肝肾功能损害。结论肾炎消白颗粒能减少慢性肾小球肾炎患者24小时尿蛋白定量;降低尿微量白蛋白/尿肌酐;减少尿中足细胞的含量;改善患者的临床症状,提高患者的生活质量;治疗组有效率有优于对照组的趋势。
[Abstract]:Objective to observe the clinical efficacy of Shenyan Xiaobai granule in the treatment of primary glomerulonephritis proteinuria, to provide a feasible and effective method for the clinical treatment of glomerulonephritis proteinuria, and to provide a good basis for clinical use of drugs. Methods from May 2014 to December 2015, 90 patients with chronic glomerulonephritis were randomly divided into treatment group (n = 45) and control group (n = 45). On the basis of routine treatment, the treatment group was treated with Shenyan Xiaobai granule, and the control group was treated with nephritis rehabilitation tablet on the basis of routine treatment. The treatment group was treated with one course of treatment every 4 weeks, and three courses of treatment were observed, and the related indexes were detected before and after treatment. And analyze the change and significance of the index. Results at each time point of the whole experiment, the indexes of the treatment group and the control group (24 hours urine protein quantity, TCM symptom score, urinary microalbumin / urine creatinine, urine podocyte content) all changed obviously. There was statistical significance (p 0.01). At the 4th week and 12th week, the curative effect of the treatment group and the control group was the same, but there was no significant difference between the treatment group and the control group (p0.05). At the 8th week, the indexes also decreased. The effective rate of 24 hours urine protein quantification in the treatment group was significantly higher than that of the control group (p0.05). The effective rate of urinary microalbumin / creatinine in the treatment group was significantly higher than that in the control group (p0.05). At 12 weeks, the urine protein quantity in the treatment group was significantly lower than that in the control group (p0.05), and no damage of liver and kidney function was found in the treatment group. Conclusion Shenyanxiaobai granule can reduce 24 hours urinary protein quantity, reduce urinary microalbumin / urinary creatinine, decrease the content of podocyte in urine, improve clinical symptoms and improve the quality of life of patients with chronic glomerulonephritis. The effective rate of the treatment group was better than that of the control group.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
，
本文编号：2353339
[Abstract]:Objective to observe the clinical efficacy of Shenyan Xiaobai granule in the treatment of primary glomerulonephritis proteinuria, to provide a feasible and effective method for the clinical treatment of glomerulonephritis proteinuria, and to provide a good basis for clinical use of drugs. Methods from May 2014 to December 2015, 90 patients with chronic glomerulonephritis were randomly divided into treatment group (n = 45) and control group (n = 45). On the basis of routine treatment, the treatment group was treated with Shenyan Xiaobai granule, and the control group was treated with nephritis rehabilitation tablet on the basis of routine treatment. The treatment group was treated with one course of treatment every 4 weeks, and three courses of treatment were observed, and the related indexes were detected before and after treatment. And analyze the change and significance of the index. Results at each time point of the whole experiment, the indexes of the treatment group and the control group (24 hours urine protein quantity, TCM symptom score, urinary microalbumin / urine creatinine, urine podocyte content) all changed obviously. There was statistical significance (p 0.01). At the 4th week and 12th week, the curative effect of the treatment group and the control group was the same, but there was no significant difference between the treatment group and the control group (p0.05). At the 8th week, the indexes also decreased. The effective rate of 24 hours urine protein quantification in the treatment group was significantly higher than that of the control group (p0.05). The effective rate of urinary microalbumin / creatinine in the treatment group was significantly higher than that in the control group (p0.05). At 12 weeks, the urine protein quantity in the treatment group was significantly lower than that in the control group (p0.05), and no damage of liver and kidney function was found in the treatment group. Conclusion Shenyanxiaobai granule can reduce 24 hours urinary protein quantity, reduce urinary microalbumin / urinary creatinine, decrease the content of podocyte in urine, improve clinical symptoms and improve the quality of life of patients with chronic glomerulonephritis. The effective rate of the treatment group was better than that of the control group.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
，
本文编号：2353339
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