阿尔茨海默病在中医学证型及维吾尔医学异常体液质分型的临床实验研究

发布时间：2018-11-25 07:47

【摘要】：目的:通过症、舌、脉辨识及实验测定载脂蛋白E基因型,探讨阿尔茨海默病在中医学及维吾尔医学在辨证分型分布规律方面的研究。方法:将202例阿尔茨海默病患者通过比较中医学和维吾尔医学的症状、舌质、脉象的分布情况,较全面总结出本病在中医学与维吾尔医学证型中的分布特点。按中医学辨证分6型:髓海不足证、肝肾阴虚证、脾肾两虚证、气滞血瘀证、痰浊阻窍证和心肝火旺证。按维吾尔医学异常体液质分型分4型:异常黑胆质型、异常粘液质型、异常胆液质型、异常血液质型,另设正常组30人。通过对232例纳入对象进行载脂蛋白E基因型测定,以便了解本病在中医学及维吾尔医学的证型特点。结果:(1)中医学证型分布特点:髓海不足证脾肾两虚证气滞血瘀证肝肾阴虚证心肝火旺证痰浊阻窍证;维吾尔医学异常体液质分型分布特点:异常黑胆质型异常粘液质型异常胆液质型异常血液质型。(2)研究病例组与正常组在载脂蛋白E各个基因型中的分布情况,均以ε3/3比例最高,正常组中ε3/3频率分布构成比(73.4%)较病例组ε3/3(54.5%)高,病例组ε3/4频率分布构成比(29.2%)明显高于正常组(3.3%),且差异有统计学意义(P0.01),病例组ε4等位基因与正常组比较分布差异有统计学意义(P0.05)。(3)中医学证型中脾肾两虚证、肝肾阴虚证以及痰浊阻窍证与含有ε4等位基因比较差异均有统计学意义(P0.05),而髓海不足证与含有ε4等位基因比较差异有显著统计学意义(P0.01)。(4)维吾尔医学异常体液质分型中,异常黑胆质型与含有ε4等位基因比较差异均有统计学意义(P0.05)。结论:通过以症状、舌脉辨识分型,借助载脂蛋白E基因型的测定得出,含有ε4等位基因的老年人易患阿尔茨海默病,故得出中医学辨证为髓海不足证、脾肾两虚证、肝肾阴虚证、痰浊阻窍证的老年人易患阿尔茨海默病;维吾尔医学异常体液质分型中,异常黑胆质型的老年人群易患阿尔茨海默病。
[Abstract]:Objective: to study the distribution of Alzheimer's disease in TCM and Uygur medicine. Methods: 202 cases of Alzheimer's disease were compared with the distribution of symptoms, tongue quality and pulse in traditional Chinese medicine (TCM) and Uygur medicine (Uygur). According to TCM syndrome differentiation, there were 6 types: deficiency of marrow and sea, deficiency of liver and kidney, deficiency of spleen and kidney, stagnation of qi and blood stasis, phlegm and turbid obstruction of orifices, and flourishing of heart, liver and fire. According to Uygur medical abnormal humoral type, there were 4 types: abnormal black bile type, abnormal mucus type, abnormal bile fluid type, abnormal blood type, and 30 normal persons. The apolipoprotein E genotypes were determined in 232 subjects in order to understand the syndromes of the disease in traditional Chinese medicine and Uygur medicine. Results: (1) the distribution of TCM syndromes: deficiency of spleen and kidney, stagnation of qi and blood stasis, syndrome of deficiency of liver and kidney yin, flourishing of heart, liver and fire, phlegm and turbid obstruction of orifices; The distribution characteristics of abnormal humoral type in Uygur medicine: abnormal black bile type abnormal mucus type abnormal bile fluid type abnormal blood type. (2) the distribution of apolipoprotein E genotypes in case group and normal group were studied. The ratio of 蔚 3 / 3 frequency distribution in normal group (73.4%) was higher than that in case group (54.5%). The frequency composition ratio of 蔚 3 / 4 in the case group (29.2%) was significantly higher than that in the normal group (3.3%), and the difference was statistically significant (P0.01). The distribution of 蔚 4 allele in the case group was significantly different from that in the normal group (P0.05). (3). There were significant differences between the syndrome of liver and kidney yin deficiency, phlegm turbid obstruction of orifices and the alleles containing 蔚 4 (P0.05). However, there was a significant difference between the deficiency of myeloid sea syndrome and the allele containing 蔚 4 (P0.01). (4) in Uygur medical abnormal body fluid typing. There was significant difference between the abnormal melanoglastic type and the allele containing 蔚 4 (P0.05). Conclusion: according to the symptoms and tongue vein identification and the determination of apolipoprotein E genotype, the elderly with 蔚 4 allele are susceptible to Alzheimer's disease, so it is concluded that the syndrome differentiation of TCM is deficiency of marrow and kidney, deficiency of spleen and kidney, and deficiency of spleen and kidney. The old people with liver and kidney yin deficiency syndrome and phlegm turbid obstruction syndrome are susceptible to Alzheimer's disease; In Uygur medical abnormal humoral typing, the elderly with abnormal black bile are susceptible to Alzheimer's disease.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

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