青鹏膏剂穴位贴敷对大鼠血清组织胺和缓激肽含量的影响

发布时间：2018-11-26 15:41

【摘要】：目的:观察青鹏膏剂大椎穴贴敷对大鼠血清中组织胺和缓激肽含量的影响。方法:雄性Wistar大鼠30只,随机分为青鹏膏剂穴位贴敷组、电针组和空白对照组,每组10只。青鹏膏剂组大鼠大椎穴区局部剃毛后涂抹青鹏膏剂,电针组大鼠大椎穴给予电针刺激。采用酶联免疫技术检测大鼠血清中组织胺和缓激肽的含量。结果:与空白对照组比较,青鹏膏剂穴位贴敷组和电针组大鼠血清组织胺和缓激肽的含量均明显升高(P0.05),且青鹏膏剂穴位贴敷组大鼠血清组织胺的含量明显高于电针组(P0.05)、缓激肽含量与电针组比较差异无统计学意义(P0.05)。结论:青鹏膏剂穴位贴敷可致大鼠血清组织胺和缓激肽的含量明显升高,这可能是青鹏膏剂药效作用的机制之一。
[Abstract]:Aim: to observe the effect of Qingpeng plaster on the contents of histamine and bradykinin in serum of rats. Methods: thirty male Wistar rats were randomly divided into Qingpeng plaster acupoint application group, electroacupuncture group and blank control group with 10 rats in each group. The rats in Qingpeng paste group were smeared with Qingpeng plaster after local shaving, and the rats in electroacupuncture group were stimulated by electroacupuncture at Dazhui point. The contents of histamine and bradykinin in rat serum were detected by enzyme-linked immunosorbent assay (Elisa). Results: compared with the blank control group, the contents of histamine and bradykinin in serum of the rats in the Qingpeng plaster group and electroacupuncture group were significantly higher than those in the control group (P0.05). The content of serum histamine in Qingpeng plaster group was significantly higher than that in electroacupuncture group (P0.05), and there was no significant difference in bradykinin content compared with electroacupuncture group (P0.05). Conclusion: the content of histamine and bradykinin in serum of rats can be significantly increased by applying Qingpeng plaster at acupoint, which may be one of the mechanisms of Qingpeng plaster.
【作者单位】：承德医学院;华北理工大学;
【基金】：河北省自然科学基金项目(No.H2014406047) 河北省高等学校科学技术研究重点项目(No.ZD20131001)
【分类号】：R245

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