解郁汤治疗肝气郁结型心血管神经症的临床疗效观察

发布时间：2018-12-10 19:37

【摘要】：目的：观察解郁汤治疗肝气郁结型心血管神经症(Cardiovascular Neurosis, CN)的临床疗效及安全性,为中医临床治疗心血管神经症提供新的治疗思路和方法。方法：选取2015年5月至2016年1月在徐州市中医院就诊的肝气郁结型心血管神经症住院患者60例。将患者进行随机分组,对照组28例,采用常规治疗方法：盐酸舍曲林、劳拉西泮片,合并心理干预。治疗组加服解郁汤。15天为一个疗程,共服用2个疗程,观察结束后,比较两组治疗前后汉密尔顿量表、中医证候积分量表、生活质量评定量表(SF-36)和安全性指标的改变。运用SPSS 19.0统计软件进行结果分析。结果：治疗后两组中医证候积分量表、HAMA、HAMD量表评分均有明显降低,治疗组与对照组相比较,积分降低更为显著(P0.05),差异有统计学意义,且治疗组总有效率高于对照组,存在统计学差异(P0.05),提示解郁汤治疗CN的临床疗效更为显著,治疗后两组患者的生活质量自评量表的评分均明显升高。但治疗组在改善患者参与社会活动的能力、进行正常的工作、改善心理健康方面疗效更为显著。结论：解郁汤联合西药及心理疗法可以显著改善肝气郁结型心血管神经症患者的临床症状,改善预后,无不良反应,安全性相对较好,值得临床推广及应用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jieyu decoction (JYD) in the treatment of cardiovascular neurosis of stagnation of liver-qi type (Cardiovascular Neurosis, CN), and to provide a new method for the treatment of cardiovascular neurosis in traditional Chinese medicine (TCM). Methods: from May 2015 to January 2016, 60 inpatients with liver qi depression cardiovascular neurosis were selected from Xuzhou Hospital of traditional Chinese Medicine. The patients were randomly divided into control group (n = 28) and control group (n = 28). The routine treatment methods were sertraline hydrochloride, lorazepam tablets and psychological intervention. The treatment group was treated with Jieyu decoction. 15 days was a course of treatment, and two courses of treatment were taken. After observation, the Hamilton scale and TCM syndrome integral scale before and after treatment were compared between the two groups. Changes of quality of life rating scale (SF-36) and safety index. The results were analyzed by SPSS 19.0 software. Results: after treatment, the scores of TCM syndrome integral scale and HAMA,HAMD scale in the two groups were significantly decreased, and the scores in the treatment group were significantly lower than those in the control group (P0.05), the difference was statistically significant. The total effective rate of the treatment group was higher than that of the control group, there was statistical difference (P0.05), suggesting that the clinical efficacy of Jieyu decoction in the treatment of CN was more significant, and the quality of life scale scores of the two groups were significantly increased after treatment. But the treatment group is more effective in improving patients' ability to participate in social activities, performing normal work and improving mental health. Conclusion: Jieyu decoction combined with western medicine and psychotherapy can significantly improve the clinical symptoms and prognosis of patients with liver qi depression cardiovascular neurosis.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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