基于关联规则的脑出血中医用药规律研究

发布时间：2018-12-10 21:06

【摘要】：目的:运用关联规则方法分析中医治疗脑出血方剂,挖掘所选用的主要药物及其用药规律,为临床治疗脑出血提供参考。方法:搜集2005年-2015年符合纳入标准的文献中用中药治疗脑出血的方剂,选用内治方剂作为数据集,运用SPSS Clementine 12.0数据挖掘软件对其药物进行关联规则分析,选用关联规则Apriori算法建立数据挖掘模型,最小支持度为10%,最小置信度为70%,并对药物配伍组合运用Web节点进行展示。结果:符合标准的治疗脑出血方剂共157首,所用药物共152味,总频数1575次,使用频数在10次以上的药物共45味,共使用1290次,占脑出血药物使用总频数的81.90%。其中活血化瘀药应用频数最高,为373次,占总频数的23.68%,其后依次为:清热药、平肝息风药、补虚药、化痰药、泻下药、止血药、开窍药、利水渗湿药、理气药、解表药、安神药、祛风湿药、化湿药、收涩药、温里药、消食药。共得到符合条件的药物关联规则376条,其中包含桃仁的规则最多,为217条。结论:活血化瘀药为治疗脑出血的主要药物,常相须为用,或与平肝息风药、补虚药、清热药配伍使用。桃仁为治疗脑出血第一要药。通过关联规则分析,可以挖掘出方剂数据库中隐藏的药物配伍规律,为临床用药提供方法和参考。
[Abstract]:Objective: to analyze the prescription of traditional Chinese medicine (TCM) for intracerebral hemorrhage by using association rule method, and to find out the main drugs used and their application rules, so as to provide reference for clinical treatment of intracerebral hemorrhage. Methods: the prescriptions for intracerebral hemorrhage were collected from 2005 to 2015, and the drug association rules were analyzed by SPSS Clementine 12.0 data mining software. The association rule Apriori algorithm is used to establish the data mining model. The minimum support is 10 and the minimum confidence is 70. The combination of drugs is displayed with Web node. Results: there were 157 prescriptions to treat intracerebral hemorrhage, 152 kinds of drugs were used, the total frequency was 1575 times, and 45 kinds of drugs were used more than 10 times, totally 1290 times, accounting for 81.90% of the total frequency of drug use in intracerebral hemorrhage. Among them, the application frequency of drugs for promoting blood circulation and removing stasis is the highest, 373 times, accounting for 23.68 times of the total frequency, followed by: heat-clearing medicine, medicine for calming the liver and relieving wind, medicine for tonifying deficiency, medicine for resolving phlegm, medicine for diarrhea, medicine for hemostasis, medicine for resuscitation, medicine for promoting water and infiltrating dampness, medicine for regulating qi, Antipods, antipsychotics, antirheumatic drugs, dehumidification drugs, astringent drugs, warm medicine, antiseptic drugs. A total of 376 eligible drug association rules were obtained, including 217 rules containing peach kernel. Conclusion: the drugs of activating blood circulation and removing blood stasis are the main drugs for treating cerebral hemorrhage, which should be used in combination with the drugs of calming the liver and relieving the wind, tonifying the deficiency and clearing the heat. Peach kernel is the first medicine to treat cerebral hemorrhage. By analyzing association rules, we can find out the hidden law of drug compatibility in prescription database, and provide methods and references for clinical use of drugs.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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