逍遥散加减治疗肝郁气滞型黄褐斑的临床疗效观察

发布时间：2018-12-14 01:25

【摘要】：目的:黄褐斑是临床上常见的损美性疾病之一,虽极少有自觉不适症状,但病情迁延日久,给患者身心造成极大的困扰。本次研究通过观察中西医结合治疗肝郁气滞型黄褐斑的疗效,以客观的角度分析中西医内外治法相结合的疗效,为黄褐斑的治疗方法提供参考依据。材料与方法:本次研究的56例黄褐斑患者均选自于2015年3月至2016年9月期间,就诊于辽宁中医药大学附属医院皮肤科门诊患者。采用随机分组法,将患者分为治疗组(逍遥散加减100ml日2次口服,围刺法以及维生素C100mg、维生素E100mg日3次口服)和对照组(维生素C、维生素E口服联合针灸围刺法),各28例。两组均以4周为一个疗程,共两个疗程。观察并记录每个疗程末两组患者的症状。结果:1.第一疗程结束时,治疗组总有效率为35.71%,对照组总有效率为39.29%,两组患者MASI评分(P=0.7830.05),疗效差异不存在统计学意义。表明两组治疗方法疗效相似。2.疗程结束时,治疗组总有效率为88.89%,对照组总有效率为57.69%,两组患者MASI评分(P=0.010.05),疗效差异存在统计学意义。表明治疗组治疗方法具有更好疗效。3.两个月后随访一次,两组患者评分均有所升高,但总体治疗组低于对照组。随访结果:治疗组复发率为27.27%,对照组复发率为64.29%,表明对照组的复发率高于治疗组。结论:1、逍遥散加减可有效改善肝郁气滞型黄褐斑患者的症状。2、逍遥散加减、围刺法结合维生素C及维生素E能够有效缩小肝郁气滞型黄褐斑患者的皮损面积及使斑片颜色变浅。3、逍遥散加减、围刺法结合维生素C及维生素E治疗肝郁气滞型黄褐斑效果优于维生素C及维生素E联合针灸围刺法治疗的疗效,值得临床推广应用。
[Abstract]:Objective: chloasma is one of the most common diseases in clinic. Although there are few symptoms of malaise, the disease is prolonged for a long time. In this study, we observed the curative effect of combination of traditional Chinese and western medicine in treating chloasma with stagnation of liver and qi, and analyzed the curative effect of combination of internal and external treatment of traditional Chinese and western medicine in order to provide reference for the treatment of chloasma. Materials and methods: 56 cases of chloasma were selected from March 2015 to September 2016. The patients were randomly divided into two groups: treatment group (Xiaoyao Powder plus or subtractive 100ml twice daily, peri-acupuncture and vitamin C 100mg, vitamin E 100mg 3 times) and control group (vitamin C, vitamin E oral combined with acupuncture and moxibustion). Each 28 cases. The two groups were given 4 weeks as a course of treatment, a total of two courses of treatment. The symptoms of the two groups were observed and recorded at the end of each course. Results: 1. At the end of the first course of treatment, the total effective rate was 35.71 in the treatment group and 39.29 in the control group. The MASI score of the two groups was 0.7830.05. The results showed that the therapeutic effects of the two groups were similar. 2. 2. At the end of the course of treatment, the total effective rate of the treatment group was 88.89 and the total effective rate of the control group was 57.69. The MASI score of the two groups was 0.010.05, and the difference was statistically significant. The results showed that the treatment group had better curative effect. 3. After two months follow-up, the scores of both groups increased, but the overall treatment group was lower than the control group. The follow-up results showed that the recurrence rate was 27.27 in the treatment group and 64.29 in the control group, indicating that the recurrence rate in the control group was higher than that in the treatment group. Conclusion: 1, Xiaoyao San can effectively improve the symptoms of chloasma with stagnation of liver and qi. The peri-acupuncture method combined with vitamin C and vitamin E can effectively reduce the area of skin lesions and make the spots shallower in the patients with chloasma with stagnation of liver-qi, and add and subtract Xiaoyao San. The efficacy of peri-acupuncture combined with vitamin C and vitamin E in the treatment of chloasma with stagnation of liver-qi was better than that of vitamin C and vitamin E combined with acupuncture and moxibustion.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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