调补肝肾法治疗肝肾两虚型老年单纯收缩期高血压临床观察
发布时间：2018-12-14 13:47
【摘要】：目的:观察以调补肝肾法组方黄芪枸杞汤治疗肝肾两虚型老年单纯收缩期高血压的临床疗效。方法:将符合入选标准肝肾两虚型老年单纯收缩期高血压患者60例,随机分为治疗组和对照组各30例。所有受试者均配合低盐、低脂饮食,适当活动。治疗组口服具有调补肝肾之功效的黄芪枸杞汤,药物在云南中医学院第一附属医院煎药室,使用煎药机煎煮,一剂药煎煮3袋,每袋200ml,饭后一小时温服,每天3次,每次服药一袋。同时口服苯磺酸氨氯地平片(络活喜,由辉瑞制药有限公司生产,【批准文号】国药准字H10950224)用法:口服,5mg,每日一次;对照组予口服苯磺酸氨氯地平片(络活喜,由辉瑞制药有限公司生产,【批准文号】国药准字H10950224)用法:口服,5mg,每日一次。两组均以4周为一疗程。治疗一疗程后观察两组受试者治疗前后的疗效指标、安全性指标及服药产生的不良反应,据《中药新药临床研究原则》为主要依据制定出评分标准,得出疗效评定。结果:本课题计划观察60例,实际观察61例,治疗组31例,对照组30例。其中治疗组未完成治疗脱落1例(见表1)。应用SPSS17.0统计软件进行统计分析,治疗组改善临床症状总有效率90.00%,与对照组(66.67%)比较有显著性差异(P0.05),治疗组临床疗效优于对照组。治疗组降低血压总有效率为93.33%,与对照组(73.33%)比较有显著性差异(P0.05),治疗组降压疗效优于对照组。两组受试者治疗期间均无不良反应发生,治疗前后心率无明显变化(P0.05),实验室安全性指标治疗前后比较,无显著性差异(P0.05)。结论:通过临床观察,以调补肝肾法组方黄芪枸杞汤治疗肝肾两虚型老年单纯收缩期高血压治疗有效,且无明显副作用。
[Abstract]:Objective: to observe the clinical effect of Huangqi Lycium decoction, a prescription of tonifying liver and kidney, in treating senile simple systolic hypertension with deficiency of liver and kidney. Methods: 60 elderly patients with simple systolic hypertension with deficiency of liver and kidney were randomly divided into treatment group (n = 30) and control group (n = 30). All subjects were given a low-salt, low-fat diet and appropriate activities. In the treatment group, Huangqi Lycium barbarum decoction, which has the effect of regulating liver and kidney, was taken orally. The medicine was used in the decoction room of the first affiliated Hospital of Yunnan University of traditional Chinese Medicine. The decoction was made with a decoction machine, 3 bags of one dose of medicine, each bag of 200 ml, one hour after meals, 3 times a day, Take the medicine one bag at a time. At the same time oral administration of amlodipine benzenesulfonic acid tablets (Luohuoxi, produced by Pfizer Pharmaceutical Co., Ltd., [approval symbol] H10950224) usage: oral, 5 mg, once a day; The control group was given oral amlodipine benzenesulfonic acid tablets (Luohuoxi, produced by Pfizer Pharmaceutical Co., Ltd. [approval symbol] H10950224): oral, 5 mg, once a day. Both groups were treated with 4 weeks as a course of treatment. After one course of treatment, the efficacy index, safety index and adverse reaction of taking medicine were observed before and after treatment. According to the principles of Clinical Research of traditional Chinese Medicine (TCM), the scoring standard was established and the evaluation of curative effect was obtained. Results: 60 cases were observed, 61 cases were observed, 31 cases in treatment group and 30 cases in control group. In the treatment group, 1 case was left off without complete treatment (see table 1). Statistical analysis with SPSS17.0 software showed that the total effective rate of improving clinical symptoms in the treatment group was 90.00g, which was significantly different from that in the control group (66.67%) (P0.05). The clinical efficacy of the treatment group was better than that of the control group. The total effective rate of lowering blood pressure in the treatment group was 93.33, which was significantly different from that in the control group (73.33%) (P0.05). The antihypertensive effect of the treatment group was better than that of the control group. There were no adverse reactions in the two groups during the treatment period, no significant changes in heart rate before and after treatment (P0.05), and there was no significant difference in laboratory safety indexes before and after treatment (P0.05). Conclusion: through clinical observation, Huangqi Lycium decoction is effective in treating senile simple systolic hypertension with deficiency of liver and kidney, and has no obvious side effects.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2378711
[Abstract]:Objective: to observe the clinical effect of Huangqi Lycium decoction, a prescription of tonifying liver and kidney, in treating senile simple systolic hypertension with deficiency of liver and kidney. Methods: 60 elderly patients with simple systolic hypertension with deficiency of liver and kidney were randomly divided into treatment group (n = 30) and control group (n = 30). All subjects were given a low-salt, low-fat diet and appropriate activities. In the treatment group, Huangqi Lycium barbarum decoction, which has the effect of regulating liver and kidney, was taken orally. The medicine was used in the decoction room of the first affiliated Hospital of Yunnan University of traditional Chinese Medicine. The decoction was made with a decoction machine, 3 bags of one dose of medicine, each bag of 200 ml, one hour after meals, 3 times a day, Take the medicine one bag at a time. At the same time oral administration of amlodipine benzenesulfonic acid tablets (Luohuoxi, produced by Pfizer Pharmaceutical Co., Ltd., [approval symbol] H10950224) usage: oral, 5 mg, once a day; The control group was given oral amlodipine benzenesulfonic acid tablets (Luohuoxi, produced by Pfizer Pharmaceutical Co., Ltd. [approval symbol] H10950224): oral, 5 mg, once a day. Both groups were treated with 4 weeks as a course of treatment. After one course of treatment, the efficacy index, safety index and adverse reaction of taking medicine were observed before and after treatment. According to the principles of Clinical Research of traditional Chinese Medicine (TCM), the scoring standard was established and the evaluation of curative effect was obtained. Results: 60 cases were observed, 61 cases were observed, 31 cases in treatment group and 30 cases in control group. In the treatment group, 1 case was left off without complete treatment (see table 1). Statistical analysis with SPSS17.0 software showed that the total effective rate of improving clinical symptoms in the treatment group was 90.00g, which was significantly different from that in the control group (66.67%) (P0.05). The clinical efficacy of the treatment group was better than that of the control group. The total effective rate of lowering blood pressure in the treatment group was 93.33, which was significantly different from that in the control group (73.33%) (P0.05). The antihypertensive effect of the treatment group was better than that of the control group. There were no adverse reactions in the two groups during the treatment period, no significant changes in heart rate before and after treatment (P0.05), and there was no significant difference in laboratory safety indexes before and after treatment (P0.05). Conclusion: through clinical observation, Huangqi Lycium decoction is effective in treating senile simple systolic hypertension with deficiency of liver and kidney, and has no obvious side effects.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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