基于随机对照试验的心脉通胶囊治疗高血压的Meta分析

发布时间：2018-12-16 01:02

【摘要】：目的:基于目前现有的文献,评价心脉通胶囊降压疗效的证据水平和强度,为撰写中医高血压诊疗指南提供证据。方法:计算机检索联合手工检索国内外医学杂志,搜集2005年1月-2016年1月发表的心脉通胶囊治疗高血压的临床随机对照试验(RCTs),限定中、英文语种。按照Cochrane协作等推荐的方法评价纳入研究的方法学质量,提取有效数据后,采用Revman5.3软件进行Meta分析。结果:共纳入7个文献研究,包括860例患者的临床随机对照试验。Meta分析结果显示:单用心脉通胶囊在降压疗效方面与化学药物相比,组间差异有显著性;在改善证候方面优于化学药物,组间差异有显著性;心脉通胶囊与化学药物联合应用在降压疗效、改善血脂水平方面和化学药物相比,组间差异有显著性。结论:心脉通胶囊具有降压作用,平均比尼莫地平降低收缩压多6mmHg,降低舒张压多5mmHg;能较好的改善患者症状,在证属气阴两虚、肝阳上亢、痰浊壅盛的高血压患者治疗中疗效显著;具有一定的改善血脂的作用,可以降低血清胆固醇(TC),但作用不稳定,降低甘油三酯(TG)的作用微弱;无明显副作用,与化学药物联合应用可以降低服用降压药引起的头痛、头胀、水肿、焦虑等副作用的发生,从而提高患者的服药依从性。GRADE证据分级为Ib级证据,有选择性的推荐。
[Abstract]:Objective: to evaluate the evidence level and strength of the antihypertensive effect of Xinmaitong capsule based on the current literature, and to provide evidence for the writing of the guidelines for the diagnosis and treatment of hypertension in traditional Chinese medicine. Methods: the Chinese and English languages of clinical randomized controlled trial of Xinmaitong capsule for the treatment of hypertension were collected from January 2005 to January 2016 by computer retrieval combined with manual retrieval of Chinese and English medical journals. According to the recommended methods of Cochrane collaboration, the quality of the methodology was evaluated, and the valid data were extracted, and the Meta analysis was carried out by using Revman5.3 software. Results: a total of 7 literature studies were conducted, including 860 clinical randomized controlled trials. The results of Meta analysis showed that there was a significant difference between the two groups in the antihypertensive effect of Monoru Maitong capsule compared with that of chemical drugs. The effect of Xinmaitong capsule combined with chemical drugs on reducing blood pressure and improving blood lipid level was significantly different from that of chemical drugs. Conclusion: Xinmaitong capsule has the effect of lowering blood pressure. Compared with nimodipine, Xinmaitong capsule can decrease systolic blood pressure and diastolic blood pressure by 6 mm / g and 5 mm / g respectively. Can improve the symptoms of patients, in the syndrome of deficiency of qi and yin, hyperactivity of liver yang, phlegm turbid in the treatment of hypertension patients have a significant effect; It can reduce serum cholesterol (TC), but its effect is unstable and triglyceride (TG) has weak effect. Without obvious side effects, combined with chemical drugs can reduce the incidence of headache, head distension, edema, anxiety and other side effects caused by antihypertensive drugs, thus improving the compliance of patients. GRADE evidence is classified as Ib grade evidence. Selective recommendation.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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