柴平汤加减治疗餐后不适综合征的临床研究

发布时间：2018-12-18 17:34

【摘要】：目的:通过观察柴平汤加减治疗功能性消化不良餐后不适综合征的临床疗效,探讨柴平汤的作用机理,为临床治疗提供参考。方法:收集功能性消化不良餐后不适综合征患者60例,随机分为治疗组和对照组,每组30例。两组患者均要求调节情志,清淡易消化饮食,停用所有可能影响疗效判定的药物,记录所有患者在用药前后的症状积分。治疗组予柴平汤加减治疗,对照组予达利通颗粒治疗,疗程均为4周,治疗结束后,比较两组治疗前后的症状积分及综合疗效。采用SPSS17.0统计软件对所有数据进行统计分析。结果:1、治疗组30例,痊愈8例,显效11例,好转9例,无效2例,总有效率93.3%;对照组30例,痊愈2例,显效4例,好转18例,无效6例,总有效率80.0%;提示治疗组临床综合疗效优于对照组,总有效率优于对照组(P0.01)。2、两组患者的症状总积分、单症积分,治疗前后相比均有好转,治疗后与治疗前比较有差异(P0.05),其中在腹胀、早饱、嗳气、烦躁、精神疲惫、肢体疲乏、上腹痛、纳食减少症状改善方面,治疗组效果优于对照组(P0.05)。在咽部梗阻感、上腹灼热症状改善上,两组结果无显著差异(P0.05)。3、两组患者在治疗期间均未发生明显的不良反应,其治疗前后实验室检查血、尿、便常规、肝功及肾功均未发现明显异常。相关数据经统计学分析,无统计学意义(P0.05),两组药物治疗PDS,无毒副作用,安全可靠。结论:柴平汤加减治疗功能性消化不良餐后不适综合征疗效显著,其总有效率高于对照组,在改善患者腹胀、早饱、嗳气等症状及临床综合疗效方面,优于对照组,未发生明显的不良反应。
[Abstract]:Objective: to observe the clinical effect of Qaiping decoction on functional dyspepsia postprandial discomfort syndrome and to explore the mechanism of Qaiping decoction. Methods: 60 patients with functional dyspepsia were randomly divided into treatment group (n = 30) and control group (n = 30). The patients in both groups were required to adjust their emotions, to digest their diet easily, to stop all drugs that might affect the evaluation of curative effect, and to record the symptom scores of all patients before and after the treatment. The treatment group was treated with Qaiping decoction and the control group was treated with Dalitong granule for 4 weeks. After the treatment, the symptom score and the comprehensive curative effect of the two groups before and after treatment were compared. All the data were analyzed by SPSS17.0 software. Results: 1. In the treatment group, 30 cases were cured, 8 cases were cured, 11 cases were improved, 9 cases were improved, 2 cases were ineffective, the total effective rate was 93.3 cases, in the control group, 30 cases were cured, 2 cases were cured, 4 cases were markedly effective, 18 cases were improved, 6 cases were ineffective, the total effective rate was 80.0g. It is suggested that the clinical comprehensive curative effect of the treatment group is better than that of the control group, and the total effective rate is better than that of the control group (P0.01). After treatment compared with the treatment before the difference (P0.05), which in abdominal distension, early satiety, belching, irritability, mental fatigue, limb fatigue, upper abdominal pain, reducing symptoms of food intake improvement, the treatment group was better than the control group (P0.05). There was no significant difference between the two groups in the improvement of pharyngeal obstruction and the symptoms of upper abdominal burning (P0.05). 3. There was no significant adverse reaction between the two groups during the treatment, and the blood, urine, and routine tests were performed in the laboratory before and after treatment. No obvious abnormality was found in liver function and renal function. Related data were statistically analyzed, no statistical significance (P0.05), the two groups of drug treatment PDS, no side effects, safe and reliable. Conclusion: Qaiping decoction has a significant curative effect on functional dyspepsia postprandial discomfort syndrome, and its total effective rate is higher than that of control group. It is superior to the control group in improving abdominal distension, early satiety, belching and other symptoms and clinical comprehensive curative effect. There was no obvious adverse reaction.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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